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Androgen receptor CAG repeat polymorphism is not associated with insulin resistance and diabetes among South Asian males

Objective To study relationship between androgen receptor (AR) CAG repeat polymorphism, insulin resistance (IR), β-cell function and other clinical/biochemical parameters in ethnic South Asian adults. A case (males with diabetes), control (males without diabetes) study, was conducted and 110 males were invited. Anthropometry, blood pressure and biochemical parameters (fasting...

Glenoid baseplate fixation using hybrid configurations of locked and unlocked peripheral screws

Background The use of peripheral locked screws has reduced glenoid baseplate failure rates in reverse shoulder arthroplasty. However, situations may arise when one or more non-locked screws may be preferred. We aimed to determine if different combinations of locked and non-locked screws significantly alter acute glenoid baseplate fixation in a laboratory setting. Materials and...

Within-class differences of the sulfonylureas should be accounted for. Reply to Schrijnders D, Kleefstra N and Landman GWD [letter]

Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital , Old Road, Headington, Oxford OX3 7LJ , UK 3 Jonathan C. Levy Glucose clamp; Hypoglycaemia; Insulin secretion; Sulfonylurea

Ethnicity and neighbourhood deprivation determines the response rate in sexual dysfunction surveys

Background Self-administered questionnaires provide a better alternative to disclose sensitive information in sexual health research. We describe the factors that determine the positive response (initial recruitment) to an initial invitation and subsequent completion of study to a postal questionnaire on sexual dysfunction. Methods South Asians (SA) and Europids with and without...

The effect of glibenclamide on insulin secretion at normal glucose concentrations

Aims/hypothesis The aim of this study was to investigate the incremental and proportional effect of a sulfonylurea on insulin secretion rates at low, elevated and high blood glucose, using parallel groups with ascending or descending glucose steps to minimise potential biases of a single stepped clamp order. Methods Following 14 days on placebo or glibenclamide (2.5 mg) tablets...

Expansion of the Homeostasis Model Assessment of β-Cell Function and Insulin Resistance to Enable Clinical Trial Outcome Modeling Through the Interactive Adjustment of Physiology and Treatment Effects: iHOMA2

OBJECTIVE To describe and make available an interactive, 24-variable homeostasis model assessment (iHOMA2) that extends the HOMA2 model, enabling the modeling of physiology and treatment effects, to present equations of the HOMA2 and iHOMA2 models, and to exemplify iHOMA2 in two widely differing scenarios: changes in insulin sensitivity with thiazolidinediones and changes in...

Linguistic validation of the Sexual Inhibition and Sexual Excitation Scales (SIS/SES) translated into five South Asian languages: Oxford Sexual Dysfunction Study (OSDS)

Background The purpose of the linguistic validation of the Sexual Inhibition and Sexual Excitation Scales (SIS/SES) was to produce translated versions in five South Asian languages (Hindi, Urdu, Panjabi, Tamil and Sinhalese) that was “conceptually equivalent” to the original U.S. English version, for use in the Oxford Sexual Dysfunction Study (OSDS). Methods Initially an expert...

Use and Abuse of HOMA Modeling

TARA M. WALLACE 0 JONATHAN C. LEVY 0 DAVID R. MATTHEWS 0 0 From the Oxford Centre for Diabetes, Endocrinology and Metabolism, The Churchill Hospital, Oxford, U.K. Endocrinology and Metabolism, The

Randomized Dose Ranging Study of the Reduction of Fasting and Postprandial Glucose in Type 2 Diabetes by Nateglinide (A-4166)

Biochemistry, Addenbrookes Hospital, Cambridge; and the 2Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, U.K. Address correspondence and reprint requests to Dr. Jonathan C. Levy, The Radcliffe

Recent Developments: Newkirk v. Newkirk: In Child's Best Interest, Sibling Awarded Custody of Minor Children over Parent's Protest

desire, to care for them. -Jonathan c. Levy Campbell v. Montgomery County Bd. of Educ.: FEMALE MINOR DOES NOT ASSUME RISK OF SEXUAL ASSAULT WHEN IMPERMISSIBLY ENTERING BOYS' LOCKER ROOM In Campbell 'V

Significant Linkage of BMI to Chromosome 10p in the U.K. Population and Evaluation of GAD2 as a Positional Candidate

Obesity is a major health problem, and many family-based studies have suggested that it has a strong genetic basis. We performed a genome-wide quantitative trait linkage scan for loci influencing BMI in 573 pedigrees from the U.K. We identified genome-wide significant linkage (logarithm of odds = 3.74, between D10S208 and D10S196, genome-wide P = 0.0186) on chromosome 10p. The...

The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults

The etiopathological relationship between latent autoimmune diabetes in adults (LADA) and classical type 1 (insulin dependent) diabetes remains unclear. Variation at the insulin gene variable number of tandem repeats (VNTR) minisatellite influences susceptibility to type 1 diabetes, but studies in LADA have been small and inconsistent. We examined the role of insulin gene...

Young-Onset Type 2 Diabetes Families Are the Major Contributors to Genetic Loci in the Diabetes UK Warren 2 Genome Scan and Identify Putative Novel Loci on Chromosomes 8q21, 21q22, and 22q11

Timothy M. Frayling Steven Wiltshire Graham A. Hitman Mark Walker Jonathan C. Levy Mike Sampson Christopher J. Groves Stephan Menzel Mark I. McCarthy Andrew T. Hattersley - A young onset of type 2

Association Studies of Insulin Receptor Substrate 1 Gene (IRS1) Variants in Type 2 Diabetes Samples Enriched for Family History and Early Age of Onset

Eleftheria Zeggini James Parkinson Stephanie Halford Katharine R. Owen Timothy M. Frayling Mark Walker Graham A. Hitman Jonathan C. Levy Mike J. Sampson Edith J.M. Feskens Andrew T. Hattersley Mark I

Polymorphisms in Type II SH2 Domain–Containing Inositol 5-Phosphatase (INPPL1, SHIP2) Are Associated With Physiological Abnormalities of the Metabolic Syndrome

Type II SH2 domain–containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity. INPPL1 mutations affecting gene function have been found in rat models of type 2 diabetes and hypertension and in type 2 diabetic patients. We investigated the influence of nucleotide variation in INPPL1 on components of the metabolic syndrome...

Evidence From a Large U.K. Family Collection That Genes Influencing Age of Onset of Type 2 Diabetes Map to Chromosome 12p and to the MODY3/NIDDM2 Locus on 12q24

Additional information on genetic susceptibility effects relevant to type 2 diabetes pathogenesis can be extracted from existing genome scans by extending examination to related phenotypes such as age at disease onset. In this study, we report the reanalysis of data from 573 U.K. sibships ascertained for multiplex type 2 diabetes, using age at onset (assessed by the proxy measure...

Association and Haplotype Analysis of the Insulin-Degrading Enzyme (IDE) Gene, a Strong Positional and Biological Candidate for Type 2 Diabetes Susceptibility

Christopher J. Groves Steven Wiltshire Damian Smedley Katherine R. Owen Timothy M. Frayling Mark Walker Graham A. Hitman Jonathan C. Levy Stephen O'Rahilly Stephan Menzel Andrew T. Hattersley Mark I

Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic β-Cell KATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes

Anna L. Gloyn Michael N. Weedon Katharine R. Owen Martina J. Turner Bridget A. Knight Graham Hitman Mark Walker Jonathan C. Levy Mike Sampson Stephanie Halford Mark I. McCarthy Andrew T. Hattersley

The Gene INPPL1, Encoding the Lipid Phosphatase SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man

Evelyne Marion 3 Pamela Jane Kaisaki 1 Vale rie Pouillon 3 Cyril Gueydan 0 Jonathan C. Levy 7 Andr e Bodson 6 Georges Krzentowski 6 Jean-Claude Daubresse 5 Jean Mockel 4 Jens Behrends 9 Genevie` ve