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Editorial: special issue introduction

Medical Faculty Mannheim, Centre for Biomedicine and Medical Technology Mannheim (CBTM), University of Heidelberg , TRIDOMUS-Gebäude Haus C, Ludolf-Krehl-Str. 13 - 17, 68167 Mannheim , Germany 2 Jonathan P ... . Sleeman This special issue marks several important milestones for the Metastasis Research Society (MRS) and its journal Clinical & Experimental Metastasis. First, the special issue is dedicated to Prof

Introduction of revised “Aims and Scope” for Clinical & Experimental Metastasis

̈ude Haus C , Ludolf-Krehl- Str. 13 - 17, 68167 Mannheim , Germany 2 & Jonathan P. Sleeman - As incoming Editor-in-Chief (Europe) for Clinical & Experimental Metastasis, I would like to take this

CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease

Parkinson’s disease (PD) is a progressive neurodegenerative condition that is characterised by the loss of specific populations of neurons in the brain. The mechanisms underlying this selective cell death are unknown but by using laser capture microdissection, the glycoprotein, CD24 has been identified as a potential marker of the populations of cells that are affected in PD...

TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT)

In patients with low-risk breast cancer, intraoperative radiotherapy (IORT) during breast-conserving surgery is a novel and convenient treatment option for delivering a single high dose of irradiation directly to the tumour bed. However, edema and fibrosis can develop after surgery and radiotherapy, which can subsequently impair quality of life. TGF- β is a strong inducer of the...

The metastatic niche and stromal progression

Jonathan P. Sleeman 0 0 J. P. Sleeman KIT Karlsruhe Campus Nord, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany 1 ) Centre for Biomedicine and Medical Technology Mannheim

Autochthonous Mouse Melanoma and Mammary Tumors do not Express the Pluripotency Genes Oct4 and Nanog

The homeodomain transcription factors Oct4 and Nanog maintain pluripotency and self-renewal in embryonic stem cells. In somatic cells, inappropriate expression of these genes has been associated with loss of differentiation, malignant transformation, and the acquisition of cancer stem cell-like properties. As cancer stem cells have been suggested to underlie the growth and...

CD24 Induces Expression of the Oncomir miR-21 via Src, and CD24 and Src Are Both Post-Transcriptionally Downregulated by the Tumor Suppressor miR-34a

Cancer is a complex disease process that evolves as a consequence of multiple malfunctions in key regulatory molecular networks. Understanding these networks will be essential to combat cancer. In this study, we focussed on central players in such networks. In a series of colon and breast cancer cell lines, we found that CD24 activates Src, and induces the activation of c-Jun and...

Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats

We have recently demonstrated that the anthocyanidin delphinidin (DEL), one of the most abundant dietary flavonoids, inhibits activation of ErbB and vascular endothelial growth factor receptor family members. These receptors play crucial roles in the context of tumor progression and the outgrowth of blood and lymphatic vessels. Here, we have developed an improved chemical...

Expression of M-N#1, a histo-blood group B–like antigen, is strongly up-regulated in nonapoptosing mammary epithelial cells during rat mammary gland involution

Jrg Mengwasser 0 Jonathan P. Sleeman 0 0 Forschungszentrum Karlsruhe, Institute for Toxicology and Genetics , PO Box 3640, D-76021 Karlsruhe, Germany - Antibodies against the histo-blood group