; UC, University of California 0 Josefina Coloma and Eva Harris are in the Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California, United States of
Studies in different countries have identified irregular water supply as a risk factor for dengue virus transmission. In 2013, Camino Verde, a cluster-randomised controlled trial in Managua, Nicaragua, and Mexico’s Guerrero State, demonstrated impact of evidence-based community mobilisation on recent dengue infection and entomological indexes of infestation by Aedes aegypti...
A cluster-randomized controlled trial of community mobilisation for dengue prevention in Mexico and Nicaragua reported, as a secondary finding, a higher risk of dengue virus infection in households where inspectors found temephos in water containers. Data from control sites in the preceding pilot study and the Nicaragua trial arm provided six time points (2005, 2006, 2007 and...
Little is known about enduring memory B cell (MBC) responses to Zika virus (ZIKV) and their relationship with circulating antibodies. Here we comprehensively assess MBC frequency and specificity alongside serum binding and neutralizing antibody responses to ZIKV ~2 weeks and ~8 months postinfection in 31 pediatric subjects with 0, 1 or >1 prior infections with the related dengue...
Recent literature on community intervention research stresses system change as a condition for durable impact. This involves highly participatory social processes leading to behavioural change. Before launching the intervention in the Nicaraguan arm of Camino Verde, a cluster-randomised controlled trial to show that pesticide-free community mobilisation adds effectiveness to...
Josefina Coloma and Eva Harris discuss advances in genomics in resource-limited settings and argue that access to training and capacity building in bioinformatics and data mining will be crucial for ... Diseases in Resource-Limited Settings Josefina Coloma 0 Eva Harris 0 0 1 Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California
Solving global health challenges in a sustainable manner depends on explicitly addressing scientific capacity-building needs, as well as establishing long-term, meaningful partnerships with colleagues in the developing world.
We discuss two ethical issues raised by Camino Verde, a 2011–2012 cluster-randomised controlled trial in Mexico and Nicaragua, that reduced dengue risk though community mobilisation. The issues arise from the approach adopted by the intervention, one called Socialisation of Evidence for Participatory Action. Community volunteer teams informed householders of evidence about dengue...
Clinical studies and trials require accessibility of large amounts of high-quality information in a timely manner, often daily. The integrated application of information technologies can greatly improve quality control as well as facilitate compliance with established standards such as Good Clinical Practice (GCP) and Good Laboratory Practice (GLP). We have customized and...
Health , Managua , Nicaragua. Josefina Coloma and Eva Harris are with the Division of Infectious Diseases, School of Public Health, University of California , Berkeley, California , United States of ... America 1 William Aviles , Oscar Ortega, Guillermina Kuan, Josefina Coloma, Eva Harris - Oinformation technologies ver the past several years, have been increasingly used in health applications in
for Basic Research in Parasitic Diseases, University of California , San Francisco, California 2 Authors' addresses: Scott J. Balsitis, Josefina Coloma, Diana Flores, and Eva Harris, Division of
, Berkeley, Berkeley, California (Josefina Coloma, Eva Harris). This work was supported by the Pediatric Dengue Vaccine Initiative (grant VE-1). The authors thank the phenomenal study personnel at the Centro
BackgroundDengue is the most prevalent mosquito-borne viral disease in humans and a major urban public health problem worldwide MethodsA prospective cohort study of ∼3800 children initially aged 2–9 years was established in Managua, Nicaragua, in 2004 to study the natural history of dengue transmission in an urban pediatric population. Blood samples from healthy subjects were...