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South Korean geriatrics on Beers Criteria medications at risk of adverse drug events

. Author Contributions Conceptualization: Ju Han Kim. Data curation: Grace Juyun Kim. Formal analysis: Grace Juyun Kim. Visualization: Grace Juyun Kim. Writing ± original draft: Grace Juyun Kim ... . Writing ± review & editing: Kye Hwa Lee, Ju Han Kim. 21 / 24 22 / 24 23 / 24 1. Onder G , Landi F , Cesari M , Gambassi G , Carbonin P , Bernabei R , et al. Inappropriate medication use among hospitalized

The effects of alternative splicing on miRNA binding sites in bladder cancer

: Seonggyun Han, Ju Han Kim, Dokyoon Kim, Younghee Lee. Data curation: Seonggyun Han, Dongwook Kim, Tullika Garg. Formal analysis: Seonggyun Han, Dongwook Kim, Manu Shivakumar, Tullika Garg. Investigation

Evaluation of exome variants using the Ion Proton Platform to sequence error-prone regions

The Ion Proton sequencer from Thermo Fisher accurately determines sequence variants from target regions with a rapid turnaround time at a low cost. However, misleading variant-calling errors can occur. We performed a systematic evaluation and manual curation of read-level alignments for the 675 ultrarare variants reported by the Ion Proton sequencer from 27 whole-exome sequencing...

Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing

. Methodology: Dong Soon Lee. Project administration: Dong Soon Lee. Resources: Sunghoon Kwon, Miyoung Kim. Software: Heewon Seo, Kyongok Im, Seungwoo Hwang, Ju Han Kim. Supervision: Dong Soon Lee

Carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke

To investigate the impacts of carotid plaque and intima-media thickness (IMT) on future vascular events (VEs) in the patients with acute ischemic stroke. A total of 479 consecutive Korean patients with acute ischemic stroke were divided into 2 groups according to development of VEs; VE group (65.4 ± 10.9 years) vs no VE group (62.8 ± 13.2 years). VEs were defined as the...

Characterization of a thermophilic cellulase from Geobacillus sp. HTA426, an efficient cellulase-producer on alkali pretreated of lignocellulosic biomass

A themophilic cellulase-producing bacterium was isolated from a hot spring district and identified as Geobacillus sp. HTA426. The cellulase enzyme produced by the Geobacillus sp. HTA426 was purified through ammonium sulfate precipitation and ion exchange chromatography, with the recovery yield and fold purification of 10.14% and 5.12, respectively. The purified cellulase has a...

KRAS, GNAS, and RNF43 mutations in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis

Background The prevalence and clinical significances of KRAS, GNAS, and RNF43 mutations in patients with pancreatic intraductal papillary mucinous neoplasm (IPMN) remain elusive. To evaluate the incidence of the gene mutations and clinicopathologic differences between KRAS and GNAS mutations in pancreatic cystic lesions, we performed a meta-analysis of published 33 KRAS, 11 GNAS...

New horizons in translational bioinformatics: TBC 2013

Ju Han Kim - Introduction The Translational Bioinformatics Conference (TBC) has been one of the most successful multidisciplinary conference series in the rapidly emerging field of translational

Genome Sequence Variability Predicts Drug Precautions and Withdrawals from the Market

, Paul J. Park, Ju Han Kim. All the authors have read and approved the final version of the manuscript. Kye Hwa Lee, Su Youn Baik, Soo Youn Lee, Chan Hee Park, Paul J. Park. Author Contributions

Significance of the BRAF mRNA Expression Level in Papillary Thyroid Carcinoma: An Analysis of The Cancer Genome Atlas Data

Background BRAFV600E is the most common mutation in papillary thyroid carcinoma (PTC), and it is associated with high-risk prognostic factors. However, the significance of the BRAF mRNA level in PTC remains unknown. We evaluated the significance of BRAF mRNA expression level by analyzing PTC data from The Cancer Genome Atlas (TCGA) database. Methods Data from 499 patients were...

BioSig3D: High Content Screening of Three-Dimensional Cell Culture Models

BioSig3D is a computational platform for high-content screening of three-dimensional (3D) cell culture models that are imaged in full 3D volume. It provides an end-to-end solution for designing high content screening assays, based on colony organization that is derived from segmentation of nuclei in each colony. BioSig3D also enables visualization of raw and processed 3D...

Interpretation of personal genome sequencing data in terms of disease ranks based on mutual information

Background The rapid advances in genome sequencing technologies have resulted in an unprecedented number of genome variations being discovered in humans. However, there has been very limited coverage of interpretation of the personal genome sequencing data in terms of diseases. Methods In this paper we present the first computational analysis scheme for interpreting personal...

Translational bioinformatics has now come of age: TBC 2012 collection

Ju Han Kim 0 0 Seoul National University Biomedical Informatics (SNUBI), Systems Biomedical Informatics National Core Research Center, Division of Biomedical Informatics, Seoul National University

Novel Bartonella Species in Insectivorous Bats, Northern China

Bartonella species are emerging human pathogens. Bats are known to carry diverse Bartonella species, some of which are capable of infecting humans. However, as the second largest mammalian group by a number of species, the role of bats as the reservoirs of Bartonella species is not fully explored, in term of their species diversity and worldwide distribution. China, especially...

Chapter 8: Biological Knowledge Assembly and Interpretation

Most methods for large-scale gene expression microarray and RNA-Seq data analysis are designed to determine the lists of genes or gene products that show distinct patterns and/or significant differences. The most challenging and rate-liming step, however, is to determine what the resulting lists of genes and/or transcripts biologically mean. Biomedical ontology and pathway-based...

Understanding cooperativity of microRNAs via microRNA association networks

Background MicroRNAs (miRNAs) are key components in post-transcriptional gene regulation in multicellular organisms. As they control cooperatively a large number of their target genes, they affect the complexity of gene regulation. One of the challenges to understand miRNA-mediated regulation is to identify co-regulating miRNAs that simultaneously regulate their target genes in a...

RCARE: RNA Sequence Comparison and Annotation for RNA Editing

The post-transcriptional sequence modification of transcripts through RNA editing is an important mechanism for regulating protein function and is associated with human disease phenotypes. The identification of RNA editing or RNA-DNA difference (RDD) sites is a fundamental step in the study of RNA editing. However, a substantial number of false-positive RDD sites have been...

Genetic variants and risk of gastric cancer: a pathway analysis of a genome-wide association study

This study aimed to discover candidate single nucleotide polymorphisms (SNPs) for hypothesizing significant biological pathways of gastric cancer (GC). We performed an Identify Candidate Causal SNPs and Pathways (ICSNPathway) analysis using a GC genome-wide association study (GWAS) dataset, including 472,342 SNPs in 2,240 GC cases and 3,302 controls of Asian ethnicity. By...

Antiplatelet Therapy of Cilostazol or Sarpogrelate with Aspirin and Clopidogrel after Percutaneous Coronary Intervention: A Retrospective Cohort Study Using the Korean National Health Insurance Claim Database

Background/Objectives Addition of cilostazol or sarpogrelate to the standard dual antiplatelet therapy of aspirin and clopidogrel has been implemented in patients that underwent percutaneous coronary intervention (PCI) with stents in Korea. This study aimed to evaluate the efficacy and safety of triple antiplatelet therapies. Methods This retrospective cohort study was performed...