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No difference in effectiveness of treatment simplification to boosted or unboosted atazanavir plus lamivudine in virologically suppressed in HIV-1-infected patients

The authors are indebted to the patients for their involvement in this study. Author Contributions Conceptualization: Alicia Gutierrez-Valencia, Juan Pasquau, Luis Fernando LoÂpez-CorteÂs. Data ... LoÂpez-CorteÂs. Investigation: Alicia Gutierrez-Valencia, Coral GarcÂõa, Pompeyo Viciana, Yusnelkis MilaneÂs Guisado, Tamara Fernandez-Magdaleno, Juan Pasquau, Luis Fernando LoÂpez-CorteÂs. Methodology

Effect of monotherapy with darunavir/cobicistat on viral load and semen quality of HIV-1 patients

Pasquau. Conceptualization: Miguel A. LoÂpez-Ruz, Juan Pasquau, Jose Antonio Castilla. Formal analysis: Miguel A. LoÂpez-Ruz, Miguel A. LoÂpez-ZuÂñiga, Juan Pasquau, Jose Antonio Castilla. Investigation ... Alicia GutieÂrrez Valencia for calculating the levels of darunavir in seminal plasma. This article is related to the Ph.D. doctoral thesis of M.A. LoÂpez-ZuÂñiga. Author Contributions Data curation: Juan

High quality of life, treatment tolerability, safety and efficacy in HIV patients switching from triple therapy to lopinavir/ritonavir monotherapy: A randomized clinical trial

following competing interests: Juan Pasquau has received financial grants and/or honoraria from Janssen-Cilag, Bristol-MyersSquibb, Abbvie, Merck Sharp & Dohme, ViiV & Gilead as speaker fees and/or as Advisor ... concerning the study design and their careful reading of the final report. Author Contributions Conceptualization: Juan Pasquau, Carmen Hidalgo-Tenorio, Coral GarcÂõa-Vallecillos. Data curation: Juan

High prevalence and diversity of HIV-1 non-B genetic forms due to immigration in southern Spain: A phylogeographic approach

PeÂrez-Parra, Juan Pasquau, Mohamed Omar, Antonio Collado, David Vinuesa, Ana Belen Lozano, Federico GarcÂõa. Formal analysis: Santiago PeÂrez-Parra, Federico GarcÂõa. Funding acquisition: Federico ... administration: Federico GarcÂõa. Resources: Federico GarcÂõa. Software: Santiago PeÂrez-Parra. Supervision: Santiago PeÂrez-Parra, Juan Pasquau, Mohamed Omar, Antonio Collado, David Vinuesa, Ana Belen Lozano

Phylodynamic and Phylogeographic Profiles of Subtype B HIV-1 Epidemics in South Spain

Background Since 1982, HIV-1 epidemics have evolved to different scenarios in terms of transmission routes, subtype distribution and characteristics of transmission clusters. We investigated the evolutionary history of HIV-1 subtype B in south Spain. Patients & Methods We studied all newly diagnosed HIV-1 subtype B patients in East Andalusia during the 2005–2012 period. For the...

Effect of Monotherapy with Darunavir/Ritonavir on Viral Load in Seminal Fluid, and Quality Parameters of Semen in HIV-1-Positive Patients

Patients with human immunodeficiency virus type 1 (HIV-1) who receive antiretroviral therapy (ART) often achieve increased survival and improved quality of life. In this respect, monotherapy with darunavir/ritonavir (mDRV/r) can be a useful treatment strategy. This prospective study analyses the effect of mDRV/r on sperm quality and viral load in a group of 28 patients who had...

Effectiveness of Ritonavir-Boosted Protease Inhibitor Monotherapy in Clinical Practice Even with Previous Virological Failures to Protease Inhibitor-Based Regimens

Background and Objective Significant controversy still exists about ritonavir-boosted protease inhibitor monotherapy (mtPI/rtv) as a simplification strategy that is used up to now to treat patients that have not experienced previous virological failure (VF) while on protease inhibitor (PI) -based regimens. We have evaluated the effectiveness of two mtPI/rtv regimens in an actual...

Antiretroviral Therapy as a Factor Protective against Anal Dysplasia in HIV-Infected Males Who Have Sex with Males

Objectives Chronic infection with oncogenic HPV genotype is associated with the development of anal dysplasia. Antiretroviral therapy (ART) has been shown to decrease the incidence of cervical carcinoma in women with HIV. We sought to: 1) describe the prevalence and grade of anal dysplasia and HPV infection in our study subjects; 2) analyze the grade of correlation between anal...

Impact of an Evidence-Based Bundle Intervention in the Quality-of-Care Management and Outcome of Staphylococcus aureus Bacteremia

Background. Staphylococcus aureus bacteremia (SAB) is associated with significant morbidity and mortality. Several aspects of clinical management have been shown to have significant impact on prognosis. The objective of the study was to identify evidence-based quality-of-care indicators (QCIs) for the management of SAB, and to evaluate the impact of a QCI-based bundle on the...

Visceral leishmaniasis caused by Leishmania infantum in a Spanish patient in Argentina: What is the origin of the infection? Case report

Background The question "Where have you been?" is a common one asked by doctors in Northern Europe and America when faced with clinical symptoms not typical of their country. This question must also arise in the clinics of developing countries in which non-autochthonous cases such as the one described here can appear. Important outbreaks of Leishmania infantum have been recorded...