Lockman, Thomas B. Campbell, Karin Nielsen Saines, Judith S. Currier. Writing ± original draft: Elizabeth M. Stringer, Shahin Lockman, Susan Cu-uvin, Judith S. Currier. Writing ± review & editing ... : Elizabeth M. Stringer, Shahin Lockman, Thomas B. Campbell, Karin Nielsen-Saines, Fred Sawe, Susan Cu-uvin, Judith S. Currier. 10 / 12 Infection in Pregnant Women, Mothers, and Children in the Global Plan Era
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Background Visceral adiposity in the setting of HIV infection and antiretroviral therapy (ART) is not fully understood, and treatment options remain limited. Telmisartan, an angiotensin receptor blocker and partial PPAR-γ agonist, has been shown to decrease visceral fat and improve metabolic and inflammatory parameters in HIV-uninfected subjects. Methods HIV-infected subjects...
Judith S. Currier () 0 1 0 University of California , Los Angeles , Center for Clinical AIDS Research and Education, Division of Infectious Diseases , Los Angeles 1 for Bristol Meyers Squibb, Gilead
5 Teacler Nematadzira 5 Nishi Suryavanshi 5 Tapiwa Mbengeranwa 5 Amy Loftis 3 5 Michael Basar 5 Katie McCarthy 5 Judith S. Currier 5 Mary Glenn Fowler 5 for the 5 FF PROMISE Team 4 5 0 Makerere ... Conceptualization: Judith S. Currier, Mary Glenn Fowler. Data curation: Sean S. Brummel. Formal analysis: Sean S. Brummel, Konstantia Angelidou. Funding acquisition: Judith S. Currier, Mary Glenn Fowler. 14 / 16
4 Judith S Currier 0 1 0 Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California , Los Angeles, CA , USA 1 Center for Clinical AIDS Research
HDL function rather than absolute level may be a more accurate indicator for risk of developing atherosclerosis. Dysfunctional HDL has increased redox activity and reduced antioxidant properties, but it is unknown whether abnormal HDL function is associated with progression of atherosclerosis in HIV-1-infected subjects. We retrospectively measured serum HDL function in 91...
Current cell-based assays for determining the functional properties of high-density lipoproteins (HDL) have limitations. We report here the development of a new, robust fluorometric cell-free biochemical assay that measures HDL lipid peroxidation (HDLox) based on the oxidation of the fluorochrome Amplex Red. HDLox correlated with previously validated cell-based (r = 0.47, p<0.001...
Background. The relationships between soluble CD14 (sCD14), endotoxin (lipopolysaccharide [LPS]), and progression of atherosclerosis have not been defined in human immunodeficiency virus (HIV) infection. Methods. We retrospectively assessed serum sCD14 and LPS levels of 91 subjects in a prospective 3-year study of carotid artery intima-media thickness (CIMT) (AIDS Clinical Trials...
Postexposure prophylaxis after sexual exposure to human immunodeficiency virus (HIV) is recommended by state and national agencies. A cross-sectional survey of 117 Los Angeles County sites found that 17 sites (14.5%) offer postexposure prophylaxis. Ten sites (8.5%) offer postexposure prophylaxis to patients who are uninsured. General availability of postexposure prophylaxis...
Antiretroviral therapy (ART) agents potentially associated with adverse metabolic profiles are commonly used in low- and middle-income countries. We assessed risk factors for cardiovascular disease (CVD)-related morbidity and mortality in a cohort of HIV-infected, ART-treated adults in Rio de Janeiro, Brazil. Hospital records and mortality data between 2000–2010 were examined for...
Background The role of pro-inflammatory lipids in systemic immune activation in HIV infection remains largely unknown. We hypothesized that HIV-1-infected persons on antiretroviral therapy would have pro-inflammatory high density lipoprotein (HDL), and that an apoA-1 mimetic peptide might reverse the inflammatory properties of HDL in these persons. Methods Plasma was obtained...
The role of pro-inflammatory lipids in systemic immune activation in HIV infection remains largely unknown. We hypothesized that HIV-1-infected persons on antiretroviral therapy would have pro-inflammatory high density lipoprotein (HDL), and that an apoA-1 mimetic peptide might reverse the inflammatory properties of HDL in these persons. Plasma was obtained from 10 HIV-1-infected...
Hormone levels shift the immune state in HIV-uninfected pregnant and breastfeeding women away from Th1 responses and toward regulation to permit fetal tolerance. Limited data exist on inflammation during pregnancy or postpartum in HIV-infected women, though certain inflammatory markers are associated with adverse health outcomes among HIV-infected persons. We measured hsCRP, D...
Background. It is unclear whether the integrase inhibitor raltegravir (RAL) reduces inflammation and immune activation compared with ritonavir-boosted protease inhibitors (PIs). Methods. In a prospective, randomized, multicenter clinical trial that included 328 human immunodeficiency type 1 (HIV-1)–infected, treatment-naive participants were randomized to receive tenofovir...
Several large observational studies have documented the reduced risk of opportunistic infections among recipients of potent combination antiretroviral therapy. These data raise the question of whether subjects who respond to antiretroviral therapy need to continue prophylaxis for opportunistic infection. Factors to consider when deciding whether it is safe to discontinue...
Background Health benefits of postpartum antiretroviral therapy (ART) for human immunodeficiency virus (HIV) positive women with high CD4+ T-counts have not been assessed in randomized trials. Methods Asymptomatic, HIV-positive, non-breastfeeding women with pre-ART CD4+ T-cell counts ≥ 400 cells/mm3 started on ART during pregnancy were randomized up to 42 days after delivery to...
Participation of women in HIV clinical trials: the IPEC-FIOCRUZ experience Jordan E Lake1, Ruth K Friedman2, Cynthia B Cunha2, Sandra W Cardoso2, Valdilea G Veloso2, Judith S Currier1, Beatriz Grinsztejn21Division of Infectious Diseases, University of California at Los Angeles, Los Angeles, CA, USA; 2Fundação Oswaldo Cruz – Instituto de Pesquisa Clínica Evandro Chagas/IPEC, Rio...
AuthorsSearch for Robert G Micheletti in:Nature Research journals • PubMed • Google ScholarSearch for Gregory A Fishbein in:Nature Research journals • PubMed • Google ScholarSearch for Judith S Currier in:Nature
Diana H. Liao,3 Grace A. McComsey,4 Christine A. Wanke,5 Alexandra Mangili,5 Sharon L. Walmsley,6 Heather McCreath,3 Ginger L. Milne,1 Stephanie C. Sanchez,1 Judith S. Currier,3 and Jordan E. Lake3