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18 papers found.
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Apolipoprotein E gene polymorphism modifies fasting total cholesterol concentrations in response to replacement of dietary saturated with monounsaturated fatty acids in adults at moderate cardiovascular disease risk

Consumption of ≤10% total energy from fat as saturated fatty acids (SFA) is recommended for cardiovascular disease risk reduction in the UK; however there is no clear guidance on the optimum replacement nutrient. Lipid-associated single-nucleotide polymorphisms (SNPs) have been shown to modify the lipid responses to dietary fat interventions. Hence, we performed a retrospective...

Apolipoprotein E gene polymorphism modifies fasting total cholesterol concentrations in response to replacement of dietary saturated with monounsaturated fatty acids in adults at moderate cardiovascular disease risk

Consumption of ≤10% total energy from fat as saturated fatty acids (SFA) is recommended for cardiovascular disease risk reduction in the UK; however there is no clear guidance on the optimum replacement nutrient. Lipid-associated single-nucleotide polymorphisms (SNPs) have been shown to modify the lipid responses to dietary fat interventions. Hence, we performed a retrospective...

Association between egg consumption and cardiovascular disease events, diabetes and all-cause mortality

, University of Reading , Reading RG6 6AR , UK 2 Hugh Sinclair Unit of Human Nutrition, University of Reading , Reading RG6 6AR , UK 3 Julie A. Lovegrove 4 Department of Primary Care and Public Health, Cardiff

Interaction between TCF7L2 polymorphism and dietary fat intake on high density lipoprotein cholesterol

. Software: Shelini Surendran. Supervision: Vasudevan Sudha, Viswanathan Mohan, Julie A. Lovegrove, Venkatesan Radha, Karani Santhanakrishnan Vimaleswaran. Validation: Karani Santhanakrishnan Vimaleswaran ... . Writing ± original draft: Szilvia Gaal, Karani Santhanakrishnan Vimaleswaran. Writing ± review & editing: Dhanasekaran Bodhini, Basma Ellahi, Vasudevan Sudha, Mohan R. Anjana, Viswanathan Mohan, Julie A

Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies

With a growing number of prospective cohort studies, an updated dose–response meta-analysis of milk and dairy products with all-cause mortality, coronary heart disease (CHD) or cardiovascular disease (CVD) have been conducted. PubMed, Embase and Scopus were searched for articles published up to September 2016. Random-effect meta-analyses with summarised dose–response data were...

Adherence to a healthy diet in relation to cardiovascular incidence and risk markers: evidence from the Caerphilly Prospective Study

Purpose Epidemiological findings indicate that higher adherence to a healthy diet may lower cardiovascular disease (CVD) risk. The present study aimed to investigate whether adherence to a healthy diet, assessed by the Healthy Diet Indicator (HDI), Dietary Approaches to Stop Hypertension (DASH) score, and Alternative Healthy Eating Index 2010 (AHEI-2010), was associated with CVD...

Energy compensation following consumption of sugar-reduced products: a randomized controlled trial

Sciences, University of Reading , Reading, Berkshire RG6 6AP , UK 2 Julie A. Lovegrove Purpose Consumption of sugar-reformulated products (commercially available foods and beverages that have been reduced

Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?

Background We have previously demonstrated that carrying the apolipoprotein (apo) E epsilon 4 (E4+) genotype disrupts omega-3 fatty acids (n − 3 PUFA) metabolism. Here we hypothesise that the postprandial clearance of n − 3 PUFA from the circulation is faster in E4+ compared to non-carriers (E4−). The objective of the study was to investigate the fasted and postprandial fatty...

The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults

Background Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441) and postprandial lipaemia in response to a single meal; however...

The impact of MTHFR 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study

George Moschonis Magdalena Godlewska Agnieszka Surwillo Jildau Bouwman Keith Grimaldi Iwona Traczyk Christian A. Drevon Hannelore Daniel Yannis Manios J. Alfredo Martinez Wim H. M. Saris Julie A. Lovegrove

Objectively Measured Physical Activity in European Adults: Cross-Sectional Findings from the Food4Me Study

Background Comparisons of objectively measured physical activity (PA) between residents of European countries measured concurrently with the same protocol are lacking. We aimed to compare PA between the seven European countries involved in the Food4Me Study, using accelerometer data collected remotely via the Internet. Methods Of the 1607 participants recruited, 1287 (539 men and...

Erratum to: Profile of European adults interested in internet-based personalised nutrition: the Food4Me study

frequency ques onnaire, n=535 - Food allergy/intolerance, n=93 - Therapeu c diet, n=199 - Limited physical ac vity n=252 Eileen R. Gibney Lorraine Brennan Marianne C. Walsh Julie A. Lovegrove J. Alfredo

Platelet-Mediated Metabolism of the Common Dietary Flavonoid, Quercetin

. Lovegrove 0 Jonathan M. Gibbins 0 Paul Cobine, Auburn University, United States of America 0 1 Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading

Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat

Genome-wide association studies have identified SNPs reproducibly associated with type 2 diabetes (T2D). We examined the effect of genetic predisposition to T2D on insulin sensitivity and secretion using detailed phenotyping in overweight individuals with no diagnosis of T2D. Furthermore, we investigated whether this genetic predisposition modifies the responses in beta-cell...

Introduction to the DISRUPT postprandial database: subjects, studies and methodologies

Dysregulation of lipid and glucose metabolism in the postprandial state are recognised as important risk factors for the development of cardiovascular disease and type 2 diabetes. Our objective was to create a comprehensive, standardised database of postprandial studies to provide insights into the physiological factors that influence postprandial lipid and glucose responses...

Variation in the FFAR1 Gene Modifies BMI, Body Composition and Beta-Cell Function in Overweight Subjects: An Exploratory Analysis

Background FFAR1 receptor is a long chain fatty acid G-protein coupled receptor which is expressed widely, but found in high density in the pancreas and central nervous system. It has been suggested that FFAR1 may play a role in insulin sensitivity, lipotoxicity and is associated with type 2 diabetes. Here we investigate the effect of three common SNPs of FFAR1 (rs2301151...

Serum Vitamin D Concentration Does Not Predict Insulin Action or Secretion in European Subjects With the Metabolic Syndrome

HANNE L. GULSETH INGRID M.F. GJELSTAD MSC AUDREY C. TIERNEY PHD JULIE A. LOVEGROVE PHD CATHERINE DEFOORT PHD ELLEN E. BLAAK PHD JOSE LOPEZ-MIRANDA PHD BEATA KIEC-WILK ULF RISERUS PHD HELEN M. ROCHE

Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome

Glucokinase Regulatory Protein (GCKR) plays a central role regulating both hepatic triglyceride and glucose metabolism. Fatty acids are key metabolic regulators, which interact with genetic factors and influence glucose metabolism and other metabolic traits. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been of considerable interest, due to their potential to reduce...