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A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

Pheochromocytomas are neural crest–derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between tumors with VHL mutations and those with disruption of the genes encoding for succinate dehydrogenase (SDH) subunits B (SDHB) and D...

Axitinib: The evidence of its potential in the treatment of advanced thyroid cancer

Axitinib: The evidence of its potential in the treatment of advanced thyroid cancer Hari A Deshpande1, Scott Gettinger1, Julie Ann Sosa21Yale Cancer Center, Department of Medical Oncology, 2Division of Endocrine Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USAIntroduction: Thyroid cancer is a rare disease with an incidence of around 37,000...

Clinical utility of vandetanib in the treatment of patients with advanced medullary thyroid cancer

Clinical utility of vandetanib in the treatment of patients with advanced medullary thyroid cancer Hari Deshpande1,3, Vicky Marler3, Julie Ann Sosa2,31Department of Medicine, 2Department of Surgery, Yale University School of Medicine, 3Yale Cancer Center, New Haven, CT, USAAbstract: Vandetanib (ZD6474) became the first systemic agent to be approved for the treatment of metastatic...

Hürthle cell carcinoma: current perspectives

Hürthle cell carcinoma: current perspectives Sara Ahmadi,1 Michael Stang,2 Xiaoyin “Sara” Jiang,3 Julie Ann Sosa2,4,5 1Division of Endocrinology, Department of Medicine, 2Section of Endocrine Surgery, Department of Surgery, 3Department of Pathology, Duke University Medical Center, 4Duke Cancer Institute, 5Duke Clinical Research Institute, Duke University Medical Center, Durham...

Thyroidectomy Under Local Anesthesia

, Leslie S. Wu, and Julie Ann Sosa declare that they have no conflict of interest. Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects

Use of the Afirma® Gene Expression Classifier for Preoperative Identification of Benign Thyroid Nodules with Indeterminate Fine Needle Aspiration Cytopathology

Ruling out malignancy in thyroid nodules historically depended on thyroid resection and histopathological evaluation until fine needle aspiration (FNA) biopsy was introduced into the United States in the 1970's. Thyroid FNA biopsy identified a majority of thyroid nodules as benign, obviating the need for surgery in over half of the patients. However, 15%-30% of thyroid FNAs have...

What’s Old is New Again

Julie Ann Sosa 0 MA 0 FACS 0 0 Section of Endocrine Surgery, Endocrine Neoplasia Diseases Group, Department of Surgery, Duke Cancer Institute and Duke Clinical Research Institute, Duke University