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Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence

paper. Jian-feng SUN assisted in the research. Yi-min TAO and Xue-jun XU helped with data analysis. Zhi-qiang CHI provided consultation. Jing-gen LIU designed the research and revised the paper ... , Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, ChinaYu-hua Wang, Jian-feng Sun, Yi-min Tao, Xue-jun Xu, Zhi-qiang Chi & Jing-gen Liu AuthorsSearch for Yu-hua Wang

Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD

modify CHD risk. Author contribution Yuan-chao TU, Hu DING, Yu-jun XU, and Lan ZHANG performed the research; Xiao-jing WANG and Cong-xin HUANG contributed new analytical tools and reagents; Yuan-chao ... Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaHu Ding, Yu-jun Xu, Lan Zhang & Dao-wen WangCenter for

Attribute Analysis of Aridity Variability in North Xinjiang, China

Identifying the dominant meteorological factors affecting aridity variability can improve our understanding of climate change and its future trend in arid and semiarid regions. This study investigated the spatiotemporal aridity variability in North Xinjiang, China, from 1961 to 2013, based on the UNESCO aridity index (precipitation/potential evapotranspiration), and analyzed its...

Attribute Analysis of Aridity Variability in North Xinjiang, China

Identifying the dominant meteorological factors affecting aridity variability can improve our understanding of climate change and its future trend in arid and semiarid regions. This study investigated the spatiotemporal aridity variability in North Xinjiang, China, from 1961 to 2013, based on the UNESCO aridity index (precipitation/potential evapotranspiration), and analyzed its...

Adaptation to water level variation: Responses of a floating-leaved macrophyte Nymphoides peltata to terrestrial habitats

A straightforward experimental approach was carried out to study the adaptation responses of a typical floating-leaved aquatic plant Nymphoides peltata to changes in water availability. N. peltata grown in terrestrial habitat was approximately 88.77% lower in total biomass, 62.75% higher in root biomass allocation, 80.9% higher in root-shoot ratio, and 54.5% longer in leaf...

Adaptation to water level variation: Responses of a floating-leaved macrophyte Nymphoides peltata to terrestrial habitats

A straightforward experimental approach was carried out to study the adaptation responses of a typical floating-leaved aquatic plant Nymphoides peltata to changes in water availability. N. peltata grown in terrestrial habitat was approximately 88.77% lower in total biomass, 62.75% higher in root biomass allocation, 80.9% higher in root-shoot ratio, and 54.5% longer in leaf...

Numerical Investigation on Head and Brain Injuries Caused by Windshield Impact on Riders Using Electric Self-Balancing Scooters

48201, USA 5Institute of Solid Mechanics, Beihang University, Beijing 100191, China Correspondence should be addressed to Jun Xu; nc.ude.aaub@uxnuj Received 17 August 2017; Revised 12 January 2018

Numerical Investigation on Head and Brain Injuries Caused by Windshield Impact on Riders Using Electric Self-Balancing Scooters

48201, USA 5Institute of Solid Mechanics, Beihang University, Beijing 100191, China Correspondence should be addressed to Jun Xu; nc.ude.aaub@uxnuj Received 17 August 2017; Revised 12 January 2018

Improving the power for detecting overlapping genes from multiple DNA microarray-derived gene lists

Background In DNA microarray gene expression profiling studies, a fundamental task is to extract statistically significant genes that meet certain research hypothesis. Currently, Venn diagram is a frequently used method for identifying overlapping genes that meet the investigator's research hypotheses. However this simple operation of intersecting multiple gene lists, known as...

Construction of siRNA/miRNA expression vectors based on a one-step PCR process

Background RNA interference (RNAi) has become a powerful means for silencing target gene expression in mammalian cells and is envisioned to be useful in therapeutic approaches to human disease. In recent years, high-throughput, genome-wide screening of siRNA/miRNA libraries has emerged as a desirable approach. Current methods for constructing siRNA/miRNA expression vectors...

Milk consumption in relation to incidence of nasopharyngeal carcinoma in 48 countries/regions

Background Decreasing trends of nasopharyngeal carcinoma (NPC) incidence have been consistently reported in endemic populations but the etiology of NPC remains unclear. The objective of our study was to assess the international and local (Hong Kong) correlations of milk and dairy products per capita consumption with NPC incidence. Methods We conducted an ecological study in 48...

Effects of reduced β2-glycoprotein I on the expression of aortic matrix metalloproteinases and tissue inhibitor matrix metalloproteinases in diabetic mice

Background Reduced β2-glycoprotein I (reduced β2GP I), which has free sulfhydryl groups, is present in plasma and serum; it can protect vascular endothelial cells from damage due to oxidative stress in vitro. We investigated the effects of reduced β2GP I on the expression of various matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in the...

Identification and characterization of microRNAs in Clonorchis sinensis of human health significance

Background Clonorchis sinensis is a zoonotic parasite causing clonorchiasis-associated human disease such as biliary calculi, cholecystitis, liver cirrhosis, and it is currently classified as carcinogenic to humans for cholangiocarcinoma. MicroRNAs (miRNAs) are non-coding, regulating small RNA molecules which are essential for the complex life cycles of parasites and are involved...

Two members of TaRLK family confer powdery mildew resistance in common wheat

. Competing interests The authors declare that they have no competing interests. Authors’ contributions XEW, TTC and BQ designed the experiments. TTC, Jun Xu, WTW and CD performed the experiments. TTC, Jin

Prevalence and characterization of hepatitis B and C virus infections in a needle-sharing population in Northern China

Background The epidemiologies of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in specific populations in certain areas of China are poorly understood. A pilot survey of HCV/HBV infections was carried out in villages in Kuancheng County, Heben Province, where injection of sodium benzoate or amphetamines using shared needles has been a common practice. The aims of...

Lifestyle and health-related quality of life: A cross-sectional study among civil servants in China

BackgroundHealth-related quality of life (HRQoL) has been increasingly acknowledged as a valid and appropriate indicator of public health and chronic morbidity. However, limited research was conducted among Chinese civil servants owing to the different lifestyle. The aim of the study was to evaluate the HRQoL among Chinese civil servants and to identify factors might be...

Self-rated health of population in southern China: association with socio-demographic characteristics measured with multiple-item self-rated health measurement scale

Background Self-rated health (SRH) status has been increasingly acknowledged as a valid and appropriate indicator of public health and chronic morbidity. However, limited research was conducted in China due to the different culture and socioeconomic situations. The aim of this study is to assess the SRH status of the population in Southern China using multiple-item SRH...

A retrospective study of microscopic polyangiitis patients presenting with pulmonary fibrosis in China

Zuo jun Xu 1 0 1 Shuaifuyuan Street, Beijing , Dongcheng District 100730 , China 1 Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking

Whole lung lavage combined with Granulocyte-macrophage colony stimulating factor inhalation for an adult case of refractory pulmonary alveolar proteinosis

feng Sun 0 Yan xun Wang Zuo jun Xu Hui Huang 0 Equal contributors Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical