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A Super Energy Mitigation Nanostructure at High Impact Speed Based on Buckyball System

The energy mitigation properties of buckyballs are investigated using molecular dynamics (MD) simulations. A one dimensional buckyball long chain is employed as a unit cell of granular fullerene particles. Two types of buckyballs i.e. C60 and C720 with recoverable and non-recoverable behaviors are chosen respectively. For C60 whose deformation is relatively small, a dissipative...

A broad-range survey of ticks from livestock in Northern Xinjiang: changes in tick distribution and the isolation of Borrelia burgdorferi sensu stricto

Background Borreliosis is highly prevalent in Xinjiang Uygur Autonomous Region, China. However, little is known about the presence of Borrelia pathogens in tick species in this region, in addition Borrelia pathogens have not been isolated from domestic animals. Methods We collected adult ticks from domestic animals at 19 sampling sites in 14 counties in northern Xinjiang from...

A retrospective study of microscopic polyangiitis patients presenting with pulmonary fibrosis in China

Zuo jun Xu 1 0 1 Shuaifuyuan Street, Beijing , Dongcheng District 100730 , China 1 Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking

A simplified fractional order impedance model and parameter identification method for lithium-ion batteries

, 2 Engineering Research Center of Tribology and Material Protection of Ministry of Education, Henan University of Science and Technology , Luoyang, Henan , China 2 Editor: Jun Xu, Beihang University

Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells

English-language editing. Author Contributions Conceptualization: Bo Zhai, Jun Xu. Data curation: Weihua Sun, Hao Cheng. Formal analysis: Jiejie Dong, Jun Xu. Funding acquisition: Bo Zhai, Fengli Hu ... , Jun Xu. Investigation: Jiejie Dong, Bo Zhai, Weihua Sun, Fengli Hu, Hao Cheng. Methodology: Jiejie Dong, Weihua Sun. 13 / 16 Project administration: Jiejie Dong, Bo Zhai, Weihua Sun, Jun Xu. Resources

Advantages of dynamic “closed loop” stable isotope flux phenotyping over static “open loop” clamps in detecting silent genetic and dietary phenotypes

In vivo insulin sensitivity can be assessed using “open loop” clamp or “closed loop” methods. Open loop clamp methods are static, and fix plasma glucose independently from plasma insulin. Closed loop methods are dynamic, and assess glucose disposal in response to a stable isotope labeled glucose tolerance test. Using PPARα−/− mice, open and closed loop assessments of insulin...

Ag85B DNA vaccine suppresses airway inflammation in a murine model of asthma

Background In allergic asthma, Th2 lymphocytes are believed to play important roles in orchestrating airway eosinophilia and inflammation. Resetting the Th1/Th2 imbalance may have a therapeutic role in asthma. The mycobacterium tuberculosis 30-kilodalton major secretory protein (antigen 85B, Ag85B) can protect animals from M. tuberculosis infection by inducing a Th1-dominant...

Anisotropic epitaxial ZnO/CdO core/shell heterostructure nanorods

Various surface structures and polarities of one-dimensional nanostructures offer additional control in synthesizing heterostructures suitable for optoelectronic and electronic applications. In this work, we report synthesis and characterization of ZnO-CdO nanorod-based heterostructures grown on a-plane sapphire. The heterojunction formed on the sidewall surface of the nanorod...

Anisotropic surface effects on the formation of chiral morphologies of nanomaterials

Jian-Shan Wang Hai-Mu Ye Qing-Hua Qin Jun Xu Xi-Qiao Feng 0 Institute of Polymer Science and Engineering, Department of Chemical Engineering, School of Materials Science and Technology, Tsinghua

Association of Mitochondrial DNA Haplogroups with Exceptional Longevity in a Chinese Population

Background Longevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity. Methodology/Principal Findings To explore the effects of mtDNA haplogroups on the prevalence of extreme longevity (EL), a population based case-control study was conducted in Rugao – a prefecture city in...

Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling

Intrahepatic cholangiocarcinoma (ICC) is an aggressive tumor with a high fatality rate. It was recently found that parathyroid hormone-like hormone (PTHLH) was frequently overexpressed in ICC compared with non-tumor tissue. This study aimed to elucidate the underlying mechanisms of PTHLH in ICC development. The CCK-8 assay, colony formation assays, flow cytometry and a xenograft...

Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3

Autophagy is a conserved process in eukaryotes required for metabolism and is involved in diverse diseases. To investigate autophagy in skeletal muscle under hyperglycemia status, we established two hyperglycemia-rat models that differ in their circulating insulin levels, by glucose infusion and singe high-dose streptozotocin injection. We then detected expression of autophagy...

Bending-induced conductance increase in individual semiconductor nanowires and nanobelts

Reliable ohmic contacts were established in order to study the strain sensitivity of nanowires and nanobelts. Significant conductance increases of up to 113% were observed on bending individual ZnO nanowires or CdS nanobelts. This bending strain-induced conductance enhancement was confirmed by a variety of bending measurements, such as using different manipulating tips (silicon...

Biogenesis of C-Glycosyl Flavones and Profiling of Flavonoid Glycosides in Lotus (Nelumbo nucifera)

Flavonoids in nine tissues of Nelumbo nucifera Gaertner were identified and quantified by high-performance liquid chromatography with diode array detector (HPLC-DAD) and HPLC-electrospray ionization-mass spectrometry (HPLC-ESI-MSn). Thirty-eight flavonoids were identified; eleven C-glycosides and five O-glycosides were discovered for the first time in N. nucifera. Most...

Bridging the translation gap and building the translation platform: translational medicine at Peking Union Medical College Hospital

Translational medicine is a fashionable term describing the inclination of basic science and clinical researchers to ultimately help patients through facilitating the incorporation of basic research findings into clinical practice. The development of translational medicine in recent years has been rapid—focusing on a new medical research model advocating “patient-centered...

C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3ϵ

β-Adrenergic receptor-mediated cAMP or protein kinase A (PKA)-dependent modulation of cardiac potassium currents controls ventricular action potential duration (APD) at faster heart rates. HERG (KCNH2) gene mutations are associated with congenital long-QT syndrome (LQT2) and affect IKr activity, a key determinant in ventricular repolarization. Physical activity or emotional...