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Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies

Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance...

Effects of taurine on resting-state fMRI activity in spontaneously hypertensive rats

-Hung Chen, Jun-Cheng Weng, Bor-Show Tzang. Data curation: Tsai-Ching Hsu, Jun-Cheng Weng, Bor-Show Tzang. Funding acquisition: Vincent Chin-Hung Chen, Jun-Cheng Weng. Investigation: Tsai-Ching Hsu, Li ... -Jeng Chen, Hong-Chun Chou. Methodology: Tsai-Ching Hsu, Jun-Cheng Weng. Project administration: Vincent Chin-Hung Chen, Bor-Show Tzang. Writing ± original draft: Bor-Show Tzang. Writing ± review

Effects of selective serotonin reuptake inhibitors on glaucoma: A nationwide population-based study

Background Selective serotonin reuptake inhibitors (SSRIs) are one of the most commonly prescribed classes of antidepressants. Glaucoma is the second leading cause of blindness globally and iatrogenic glaucoma has been implicated across disparate medication classes. Available studies that have sought to determine the association between SSRI exposure and glaucoma have provided...

Quantitative Evaluation of Rabbit Brain Injury after Cerebral Hemisphere Radiation Exposure Using Generalized q-Sampling Imaging

Radiation therapy is widely used for the treatment of brain tumors and may result in cellular, vascular and axonal injury and further behavioral deficits. The non-invasive longitudinal imaging assessment of brain injury caused by radiation therapy is important for determining patient prognoses. Several rodent studies have been performed using magnetic resonance imaging (MRI), but...

New Insights into the Developing Rabbit Brain Using Diffusion Tensor Tractography and Generalized q-Sampling MRI

The use of modern neuroimaging methods to characterize the complex anatomy of brain development at different stages reveals an enormous wealth of information in understanding this highly ordered process and provides clues to detect neurological and neurobehavioral disorders that have their origin in early structural and functional cerebral maturation. Non-invasive diffusion...