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Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage

MicroRNAs are endogenous single-stranded non-coding small RNA molecules that can be secreted into the circulation and exist stably. They usually exhibit aberrant expression under different physiological and pathological conditions. Recently, differentially expressed circulating microRNAs were focused on as potential biomarkers for cancer screening. We herein review the role of...

Diversification of the P genome among Agropyron Gaertn. (Poaceae) species detected by FISH

The genomes of five Agropyron Gaertner, 1770 species were characterized using all potential di- or trinucleotide simple sequence repeat (SSR) motifs and four satellite DNA repeats as fluorescence in situ hybridization (FISH) probes. The sites of 5S and 45S rDNA were relatively conserved among the diploid and tetraploid species. A number of sites for the dinucleotide SSRs AC, AG...

Computation-distributed probability hypothesis density filter

Particle probability hypothesis density filtering has become a promising approach for multi-target tracking due to its capability of handling an unknown and time-varying number of targets in a nonlinear, non-Gaussian system. However, its computational complexity linearly increases with the number of obtained observations and the number of particles, which can be very time...

Theoretical and experimental investigation of fiber Bragg gratings with different lengths for ultrasonic detection

Citation: Zhouzhou YU, Qi JIANG, Hao ZHANG, and Junjie WANG, “Theoretical and Experimental Investigation of Fiber Bragg Gratings With Different Lengths for Ultrasonic Detection,” Photonic Sensors

Microstructure Evolution in the Near-Surface Region During Homogenization of a Twin-Roll Cast AlFeMnSi Alloy

JUNJIE WANG, Visiting Academic, and XIAORONG ZHOU and GEORGE E. THOMPSON, Professors, are with the School of Materials, The University of Manchester , Manchester, M13 9PL , UK. Contact A near-surface

Analysis of HIV Correlated Factors in Chinese and Vietnamese Female Sex Workers in Hekou, Yunnan Province, a Chinese Border Region

Objectives To assess the prevalence and correlated factors of HIV-1 among Chinese and Vietnamese female sex workers (FSW) in the border county of Hekou, Yunnan province, China. Methods A cross-sectional survey was conducted collecting information on demographics, sexual behavior, medical history, and drug use. Blood samples were obtained to test for HIV/STIs. Multivariate...

Permanent interstitial 125 I seed implantation as a salvage therapy for pediatric recurrent or metastatic soft tissue sarcoma after multidisciplinary treatment

Background The management of pediatric recurrent or metastatic soft tissue sarcoma after multimodal treatment remains challenging. We investigated the feasibility, efficacy, and morbidity of permanent interstitial 125 I seed implantation under image guidance as a salvage treatment for pediatric patients with recurrent or metastatic soft tissue sarcoma. Methods This was a...

The Loss of Efficiency Caused by Agents’ Uncoordinated Routing in Transport Networks

Large-scale daily commuting data were combined with detailed geographical information system (GIS) data to analyze the loss of transport efficiency caused by drivers’ uncoordinated routing in urban road networks. We used Price of Anarchy (POA) to quantify the loss of transport efficiency and found that both volume and distribution of human mobility demand determine the POA. In...

Vulnerability Analysis and Passenger Source Prediction in Urban Rail Transit Networks

Based on large-scale human mobility data collected in San Francisco and Boston, the morning peak urban rail transit (URT) ODs (origin-destination matrix) were estimated and the most vulnerable URT segments, those capable of causing the largest service interruptions, were identified. In both URT networks, a few highly vulnerable segments were observed. For this small group of...

The impact of key parameters on the cycle efficiency of multi-stage RCAES system

Bin LIU Laijun CHEN Shengwei MEI Feng LIU Junjie WANG Sixian WANG Due to the uncertainty and anti-peaking nature, large scale integration of renewable energy imposes great challenges to the ... Tsinghua University. His research concerns power system stability analysis and control. Junjie WANG received the B.S. degree in school of mechanical engineering from Xian Jiaotong University, Xian, China

SmartArc-based volumetric modulated arc therapy for endometrial cancer: a dosimetric comparison with helical tomotherapy and intensity-modulated radiation therapy

Background The purpose of the present study was to investigate the feasibility of using volumetric modulated arc therapy with SmartArc (VMAT-S) to achieve radiation delivery efficiency higher than that of intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) when treating endometrial cancer, while maintaining plan quality. Methods Nine patients with endometrial...

The Protective Effect of Esculentoside A on Experimental Acute Liver Injury in Mice

Inflammatory response and oxidative stress are considered to play an important role in the development of acute liver injury induced by carbon tetrachloride (CCl4) and galactosamine (GalN)/lipopolysaccharides (LPS). Esculentoside A (EsA), isolated from the Chinese herb phytolacca esculenta, has the effect of modulating immune response, cell proliferation and apoptosis as well as...

Effect of Misalignment between Successive Corneal Videokeratography Maps on the Repeatability of Topography Data

Purpose To improve the reliability of corneal topographic data through the development of a method to estimate the magnitude of misalignment between successive corneal videokeratography (VK) maps and eliminate the effect of misalignment on the repeatability of topography data. Methods Anterior and posterior topography maps were recorded twice for 124 healthy eyes of 124...

Positioning accuracy during VMAT of gynecologic malignancies and the resulting dosimetric impact by a 6-degree-of-freedom couch in combination with daily kilovoltage cone beam computed tomography

Background To improve the delivery of radiotherapy in gynecologic malignancies and to minimize the irradiation of unaffected tissues by using daily kilovoltage cone beam computed tomography (kV-CBCT) to reduce setup errors. Methods Thirteen patients with gynecologic cancers were treated with postoperative volumetric-modulated arc therapy (VMAT). All patients had a planning CT...

The investigation of 125I seed implantation as a salvage modality for unresectable pancreatic carcinoma

Background To assess the efficacy of intraoperative ultrasound-guided implantation of 125I seeds for the treatment of unresectable pancreatic carcinoma, and analyze the associated prognostic factors. Methods Twenty-eight patients with pancreatic carcinoma who underwent laparotomy and were considered to have unresectable tumors were included in this study. Nine patients were...

The Self-Limiting Dynamics of TGF-β Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation

The TGF-β/Smad signaling system decreases its activity through strong negative regulation. Several molecular mechanisms of negative regulation have been published, but the relative impact of each mechanism on the overall system is unknown. In this work, we used computational and experimental methods to assess multiple negative regulatory effects on Smad signaling in HaCaT cells...

Combined effects of C225 and 125-iodine seed radiation on colorectal cancer cells

Background To characterize the effect of combined treatment of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 and 125-iodine (125I) seed radiation in human colorectal cancer. Methods We treated LS180 cells with 125I continuous low dose rate radiation in the presence and absence of 100 nM C225. The clonogenic capacity, cellular proliferation, cell cycle...

The different biological effects of single, fractionated and continuous low dose rate irradiation on CL187 colorectal cancer cells

irradiation, Hao Wang, Jinna LI and Ang Qu carried out the molecular genetic studies, Hao Wang and Jingjia Liu did statistical analysis, Hao Wang, Yong Zhao and Junjie Wang participated in the sequence

CT-guidance interstitial 125Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors

Background Management of spinal neoplasms has relied on open surgery and external beam radiotherapy (EBRT). Although primary spinal tumors are rare, their treatment remains a pervasive problem. This analysis sought to evaluate the safety and efficacy of CT-guided 125I seed brachytherapy for recurrent paraspinous and vertebral primary tumors. Methods From November 2002 to June...

An investigation of 125I seed permanent implantation for recurrent carcinoma in the head and neck after surgery and external beam radiotherapy

Background A preliminary assessment was conducted of the feasibility, efficacy, and morbidity of 125I seed implantation for recurrent head and neck carcinoma after surgery and external beam radiotherapy. Methods Nineteen patients with recurrent head and neck carcinomas underwent 125I seed implantation under ultrasound or computed tomography guidance. The actuarial D90 of 125I...