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Safety and efficacy of fruquintinib in patients with previously treated metastatic colorectal cancer: a phase Ib study and a randomized double-blind phase II study

II study Rui-Hua Xu Jin Li 0 1 Yuxian Bai Jianming Xu Tianshu Liu Lin Shen Liwei Wang Hongming Pan Junning Cao 0 Dongsheng Zhang Songhua Fan Ye Hua Weiguo Su 0 Department of Medical Oncology, Fudan

A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumors

Background AST1306 is an orally active irreversible small molecule inhibitor of EGFR (erbB1), HER2 (erbB2) and HER4 (erbB4) signaling. This is a phase I, open-label, dose-escalation study to evaluate the safety and tolerability, pharmacokinetics (PK), and preliminary anti-tumor effects of oral AST1306. In addition the effects of food on PK was tested. Methods A modified Fibonacci 3 ...

Extranodal natural killer/T-cell lymphoma involving the gastrointestinal tract: analysis of clinical features and outcomes from the Asia Lymphoma study group

Jin Kim 1 Hyun Ae Jung 1 Shih-Sung Chuang Huangming Hong 0 Cheng-Cheng Guo 0 Junning Cao Xiao-Nan Hong Ritsuro Suzuki Hye Jin Kang Jong Ho Won Wee-Joo Chng Yok-Lam Kwong Cheolwon Suh Yu-Qin Song Jun Zhu