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The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy

MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London , SE1 1UL London , UK 1 Louisa K. James Allergic responses are dependent on the highly specific effector functions of

Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions

Allergic Mechanisms of Asthma, King's College London , London SE1 1UL , UK 2 Louisa K. James 3 Stephen J. Till IgG4 is the least abundant IgG subclass in human serum, representing less than 5 % of all IgG

Elevated pCO2 enhances bacterioplankton removal of organic carbon

Factors that affect the removal of organic carbon by heterotrophic bacterioplankton can impact the rate and magnitude of organic carbon loss in the ocean through the conversion of a portion of consumed organic carbon to CO2. Through enhanced rates of consumption, surface bacterioplankton communities can also reduce the amount of dissolved organic carbon (DOC) available for export...

Marital status, widowhood duration, gender and health outcomes: a cross-sectional study among older adults in India

Background Previous research has demonstrated health benefits of marriage and the potential for worse outcomes during widowhood in some populations. However, few studies have assessed the relevance of widowhood and widowhood duration to a variety of health-related outcomes and chronic diseases among older adults in India, and even fewer have examined these relationships...

Viremia and Clinical Presentation in Nicaraguan Patients Infected With Zika Virus, Chikungunya Virus, and Dengue Virus

Background. Zika virus (ZIKV), chikungunya virus (CHIKV), and dengue virus (DENV) cocirculate in Nicaragua. In this study, we sought to compare the quantified viremia and clinical presentation of patients infected with 1 or more of these viruses. Methods. Acute-phase serum samples from 346 patients with a suspected arboviral illness were tested using a multiplex real-time reverse...

Impact of thrombus aspiration during ST-Elevation Myocardial Infarction: a six month composite endpoint and risk of stroke analyses of the TASTE trial

James 2 0 Department of Cardiology, Skane University Hospital, Lund University , Lund 221 85 , Sweden 1 Department of Cardiology, Örebro University, Faculty of Health , Örebro , Sweden 2 Department of

A Legume Genetic Framework Controls Infection of Nodules by Symbiotic and Endophytic Bacteria

Legumes have an intrinsic capacity to accommodate both symbiotic and endophytic bacteria within root nodules. For the symbionts, a complex genetic mechanism that allows mutual recognition and plant infection has emerged from genetic studies under axenic conditions. In contrast, little is known about the mechanisms controlling the endophytic infection. Here we investigate the...

Improving crop mineral nutrition

Background Crops require adequate nutrition for the production of food, fibre and fuel, but soil conditions often limit the ability of crops to acquire mineral nutrients. To address this, mineral nutrients can be applied as inorganic or organic fertilisers to the soil or as liquid fertilisers to foliage. However, production and use of fertilisers can have negative environmental...

The plant microbiome

Plant genomes contribute to the structure and function of the plant microbiome, a key determinant of plant health and productivity. High-throughput technologies are revealing interactions between these complex communities and their hosts in unprecedented detail.

Function of glutathione peroxidases in legume root nodules

Glutathione peroxidases (Gpxs) are antioxidant enzymes not studied so far in legume nodules, despite the fact that reactive oxygen species are produced at different steps of the symbiosis. The function of two Gpxs that are highly expressed in nodules of the model legume Lotus japonicus was examined. Gene expression analysis, enzymatic and nitrosylation assays, yeast cell...

Effect of Stent Inflation Pressure and Post-Dilatation on the Outcome of Coronary Artery Intervention. A Report of More than 90 000 Stent Implantations

Background Percutaneous coronary intervention (PCI) stent inflation pressure correlates to angiographic lumen improvement and stent expansion but the relation to outcome is not clarified. Using comprehensive registry data our aim was to evaluate how stent inflation pressure influences restenosis, stent thrombosis and death following PCI. Methods We evaluated all consecutive...

Neuronal Function and Dysfunction of Drosophila dTDP

Background TDP-43 is an RNA- and DNA-binding protein well conserved in animals including the mammals, Drosophila, and C. elegans. In mammals, the multi-function TDP-43 encoded by the TARDBP gene is a signature protein of the ubiquitin-positive inclusions (UBIs) in the diseased neuronal/glial cells of a range of neurodegenerative diseases including amyotrophic lateral sclerosis...

P2Y12 platelet inhibition in clinical practice

. Damman S. K. James (&) Uppsala Clinical Research Center , Dag Hammarskjolds vag 50A, MTC-huset, Science Park , 6363, 751 85 Uppsala, Sweden 2 P. Damman P. Woudstra W. J. Kuijt R. J. de Winter Department of ... -effective applying conventional thresholds of costeffectiveness. Disclosures Stefan K James declares research grants and advisory board fees from AstraZeneca and honorariums from AstraZeneca, Bristol-Myers

Burkholderia Species Are the Most Common and Preferred Nodulating Symbionts of the Piptadenia Group (Tribe Mimoseae)

Burkholderia legume symbionts (also called α-rhizobia) are ancient in origin and are the main nitrogen-fixing symbionts of species belonging to the large genus Mimosa in Brazil. We investigated the extent of the affinity between Burkholderia and species in the tribe Mimoseae by studying symbionts of the genera Piptadenia (P.), Parapiptadenia (Pp.), Pseudopiptadenia (Ps...

Thiol synthetases of legumes: immunogold localization and differential gene regulation by phytohormones

In plants and other organisms, glutathione (GSH) biosynthesis is catalysed sequentially by γ-glutamylcysteine synthetase (γECS) and glutathione synthetase (GSHS). In legumes, homoglutathione (hGSH) can replace GSH and is synthesized by γECS and a specific homoglutathione synthetase (hGSHS). The subcellular localization of the enzymes was examined by electron microscopy in several...