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Abstracts from the 2012 BNOS Conference

BY HYPERMETHYLATION IN PAEDIATRIC EPENDYMOMA K Karakoula, KP Phipps, W Harkness, R Hayward, D Thompson, TS Jacques, B Harding, J Darling, and T Warr; Brain Tumour UK Neuro-Oncology Research Centre

Development of a multi-locus sequence typing scheme for Laribacter hongkongensis, a novel bacterium associated with freshwater fish-borne gastroenteritis and traveler's diarrhea

Background Laribacter hongkongensis is a newly discovered, facultative anaerobic, Gram-negative, motile, sea gull-shaped rod associated with freshwater fish borne gastroenteritis and traveler's diarrhea. A highly reproducible and discriminative typing system is essential for better understanding of the epidemiology of L. hongkongensis. In this study, a multilocus sequence typing...

Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells

Background Thalidomide is an immunomodulatory agent, which arrests angiogenesis. The mechanism of anti-angiogenic activity of thalidomide is not fully understood. As nitric oxide is involved in angiogenesis, we speculate a cross-talk between thalidomide and nitric oxide signaling pathway to define angiogenesis. The aim of present study is to understand the mechanistic aspects of...

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres

Background In the periphery, C5a acts through the G-protein coupled receptor CD88 to enhance/maintain inflammatory responses. In the brain, CD88 can be expressed on astrocytes, microglia and neurons. Previous studies have shown that the hippocampal CA3 region displays CD88-immunolabelling, and CD88 mRNA is present within dentate gyrus granule cells. As granule cells send dense...

Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome

Background A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To determine the impact of immune escape mutations selected by cytotoxic T lymphocytes (CTL) on viral fitness in the context of the cognate transmitted/founder (T/F) genome, we developed a new competitive fitness...

Altered Neocortical Cell Density and Layer Thickness in Serotonin Transporter Knockout Mice: A Quantitation Study

, Wichems CH , Feltner D , Heils A , Moessner R , Westphal H , Lesch KP . 1998 . Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine (''Ecstasy'') in serotonin ... . Program No. 481.15 , 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience [online]. Canli T , Omura K , Haas BW , Fallgatter A , Constable RT , Lesch KP . 2005 . Beyond affect: a

Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

transgenic mitochondrial cybrids generate Lewy inclusion bodies . J Neurochem 2004 , 88 : 800 - 812 . 21. Borland MK , Mohanakumar KP , Rubinstein JD , Keeney PM , Xie J , Capaldi R , Dunham LD , Trimmer PA

The approximate entropy of the electromyographic signals of tremor correlates with the osmotic fragility of human erythrocytes

Background The main problem of tremor is the damage caused to the quality of the life of patients, especially those at more advanced ages. There is not a consensus yet about the origins of this disorder, but it can be examined in the correlations between the biological signs of aging and the tremor characteristics. Methods This work sought correlations between the osmotic...

An unusual presentation of a Gastrointestinal stromal tumour (GIST)

Background Gastrointestinal stromal tumours (GIST) are rare tumours, now more frequently identified with the new imaging modalities like computerised tomography (CT) and magnetic resonance imaging (MRI). We report a rare presentation of a GIST with an unusual diagnostic workup in a multidisciplinary setting leading to a definitive diagnosis and treatment. Case presentation A 55...

Effects of pretreatment on morphology, chemical composition and enzymatic digestibility of eucalyptus bark: a potentially valuable source of fermentable sugars for biofuel production – part 1

Background In recent years, the growing demand for biofuels has encouraged the search for different sources of underutilized lignocellulosic feedstocks that are available in sufficient abundance to be used for sustainable biofuel production. Much attention has been focused on biomass from grass. However, large amounts of timber residues such as eucalyptus bark are available and...

Differential replication of avian influenza H9N2 viruses in human alveolar epithelial A549 cells

Avian influenza virus H9N2 isolates cause a mild influenza-like illness in humans. However, the pathogenesis of the H9N2 subtypes in human remains to be investigated. Using a human alveolar epithelial cell line A549 as host, we found that A/Quail/Hong Kong/G1/97 (H9N2/G1), which shares 6 viral "internal genes" with the lethal A/Hong Kong/156/97 (H5N1/97) virus, replicates...