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Future Digital Design and Manufacturing: Embracing Industry 4.0 and Beyond

. Volume 12 - The Devil is in the Details . 3rd ed. Springer, 2016 , ISBN 978-3- 319 -24436-5 electronic bk. 5. Kai Cheng, Richard Bateman J. e-Manufacturing: characteristics, applications and potentials ... China Jiaotong University of China between 1988 and 1996 . His research interest include digital design and manufacturing . He has authored/coauthored over 160 papers. Kai Cheng is a chair Professor in

Special Issue on Future Digital Design and Manufacturing: Embracing Industry 4.0 and Beyond-Part II

research and development, and good references for industrial practices. Kai Cheng is a chair Professor in Manufacturing Systems and currently the Theme Leader for Ultraprecision and Micro/Nano Manufacturing

Investigation of influence of tool rake angle in single point diamond turning of silicon

This paper presents an investigation of the effect of tool rake angle in single point diamond turning (SPDT) of silicon using experimental and simulation methods. Machining trials under the same cutting conditions were carried out using three different rake angle tools. In order to delve further into the rake angle effect on the output parameters including material removal, ...

Model-based optimization approaches for precision medicine: A case study in presynaptic dopamine overactivity

Precision medicine considers an individual’s unique physiological characteristics as strongly influential in disease vulnerability and in response to specific therapies. Predicting an individual’s susceptibility to developing an illness, making an accurate diagnosis, maximizing therapeutic effects, and minimizing adverse effects for treatment are essential in precision medicine. We ...

Investigation on Surface Polarization of Al2O3-capped GaN/AlGaN/GaN Heterostructure by Angle-Resolved X-ray Photoelectron Spectroscopy

The surface polarization of Ga-face gallium nitride (GaN) (2 nm)/AlGaN (22 nm)/GaN channel (150 nm)/buffer/Si with Al2O3 capping layer is investigated by angle-resolved X-ray photoelectron spectroscopy (ARXPS). It is found that the energy band varies from upward bending to downward bending in the interface region, which is believed to be corresponding to the polarization variation. ...

Smart Cutting Tools and Smart Machining: Development Approaches, and Their Implementation and Application Perspectives

beyond . IEEE International Conference on Automation and Computing (ICAC2015) , Glasgow, UK, September 2015 . Kai Cheng, born in December 1961 , is currently a Chair Professor and Theme Leader in

Towards A Comprehensive Framework For Technology Selection And Capacity Planning For Sustainable Manufacturing

Technology mixed perspective, as a combination of two functions of ‘Technology Selection’ and ‘Capacity Planning’, is not usually addressed in the research literature. Yet, the importance of integrated decisions at such strategic level is evident. The overall aim of this paper is to develop a framework for combined ‘technology selection’ and ‘capacity planning’ in manufacturing ...

Towards A Comprehensive Framework For Technology Selection And Capacity Planning For Sustainable Manufacturing

Technology mixed perspective, as a combination of two functions of ‘Technology Selection’ and ‘Capacity Planning’, is not usually addressed in the research literature. Yet, the importance of integrated decisions at such strategic level is evident. The overall aim of this paper is to develop a framework for combined ‘technology selection’ and ‘capacity planning’ in manufacturing ...

Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency

Model-based optimization approaches are valuable in developing new drugs for human metabolic disorders. The core objective in most optimal drug designs is positive therapeutic effects. In this study, we considered the effects of therapeutic, adverse, and target variation simultaneously. A fuzzy optimization method was applied to formulate a multiobjective drug design problem for ...

Suppliers Selection In Manufacturing Industries And Associated Multi-Objective Desicion Making Methods: Past, Present And The Future

. Soheil Hassanzadeh Kai Cheng 0 0 College of Engineering, Design and Physical Sciences, Brunel University , Uxbridge, London , UK Nowadays, many manufacturing companies have decided to use other companies

Suppliers Selection In Manufacturing Industries And Associated Multi-Objective Desicion Making Methods: Past, Present And The Future

. Soheil Hassanzadeh Kai Cheng 0 0 College of Engineering, Design and Physical Sciences, Brunel University , Uxbridge, London , UK Nowadays, many manufacturing companies have decided to use other companies

A Bernstein type inequality associated with wavelet bi-frame decomposition

Bernstein inequality is an essential inequality for Besov spaces. Smoothness based approaches are widely used in establishing the inequality. Yet, despite numerous studies over the last two decades, there is still little research focusing on decay-based approaches. However, motivating authors to establish inequality poses challenges, many of which can be overcome by means of the ...

Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer

Background Release of exosomes have been shown to play critical roles in drug resistance by delivering cargo. Targeting the transfer of exosomes from resistant cells to sensitive cells may be an approach to overcome some cases of drug resistance. Method In this study, we investigated the potential role of exosomes in the process of psoralen reverse multidrug resistance of MCF-7/ADR ...

Risks of cardiovascular diseases associated with dipeptidyl peptidase-4 inhibitors and other antidiabetic drugs in patients with type 2 diabetes: a nation-wide longitudinal study

Background Several antidiabetic drugs (i.e., sulfonylureas; SU, rosiglitazone) have been reported to be associated with increased risks of cardiovascular diseases (CVD) in patients with type 2 diabetes mellitus (T2DM). Dipeptidyl peptidase-4 inhibitors (DPP4i) are newly available antidiabetic drugs. Most studies only compared DPP4i with a placebo or SU, or targeted a specific CVD ...

Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase

Uracil-DNA glycosylases (UDGs) are highly conserved proteins that can be found in a wide range of organisms, and are involved in the DNA repair and host defense systems. UDG activity is controlled by various cellular factors, including the uracil-DNA glycosylase inhibitors, which are DNA mimic proteins that prevent the DNA binding sites of UDGs from interacting with their DNA ...

A REVIEW OF DRAG REDUCTION BY RIBLETS AND MICRO-TEXTURES IN THE TURBULENT BOUNDARY LAYERS

Drag reduction in wall-bounded flows can be achieved by the passive flow control technique, riblets. In this article, possible physical mechanisms responsible for turbulent drag reduction have been summarized. The modeling and experiments concerning the relationship between the riblets features and the turbulent boundary layer structure has also been reviewed.

A REVIEW OF DRAG REDUCTION BY RIBLETS AND MICRO-TEXTURES IN THE TURBULENT BOUNDARY LAYERS

Drag reduction in wall-bounded flows can be achieved by the passive flow control technique, riblets. In this article, possible physical mechanisms responsible for turbulent drag reduction have been summarized. The modeling and experiments concerning the relationship between the riblets features and the turbulent boundary layer structure has also been reviewed.

Pre-wavelet bases in Lebesgue spaces

Under the decay condition, we have constructed the dual wavelet basis of a pre-wavelet basis. The frame operators of both bases are bijective on Lebesgue spaces. Both bases are also unconditional bases for Lebesgue spaces. MSC: 42C40, 42C15.

Three-pathway combination for glutathione biosynthesis in Saccharomyces cerevisiae

Background Glutathione (GSH), a pivotal non-protein thiol, can be biosynthesized through three pathways in different organisms: (1) two consecutive enzymatic reactions catalyzed by γ-glutamylcysteine synthetase (Gsh1 or GshA) and glutathione synthetase (Gsh2 or GshB); (2) a bifunctional γ-glutamylcysteine synthetase/glutathione synthetase (GshF); (3) an alternative condensation of ...