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Downregulation and DNA methylation of ECRG4 in gastric cancer

Downregulation and DNA methylation of ECRG4 in gastric cancer Peng Deng,1 Xiao-Jing Chang,1 Zi-Ming Gao,2 Xiao-Yang Xu,1 An-Qi Sun,2 Kai Li,2 Dong-Qiu Dai1 1Department of Gastrointestinal Surgery and

Codesigned Wideband High-Efficiency Filtering SIW Slot Antenna with High Selectivity and Flat Gain Response

Copyright © 2018 Peng Kai Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD

© 2018 Kai Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ... rs-fMRI and the combination of rs-fMRI with other modalities are needed. Conflicts of Interest All the authors declared no relevant conflicts of interest. Authors’ Contributions Kai Li and Wen Su

Current Status and Study Progress of Recombinant Human Endostatin in Cancer Treatment

published. Disclosures. Kai Li, Mingliang Shi and Shukui Qin have nothing to disclose. Compliance with Ethics Guidelines. This article is based on previously conducted studies and does not involve any new

Web of Science use in published research and review papers 1997–2017: a selective, dynamic, cross-domain, content-based analysis

Clarivate Analytics’s Web of Science (WoS) is the world’s leading scientific citation search and analytical information platform. It is used as both a research tool supporting a broad array of scientific tasks across diverse knowledge domains as well as a dataset for large-scale data-intensive studies. WoS has been used in thousands of published academic studies over the past 20...

Autophagy is required for human umbilical cord mesenchymal stem cells to improve spatial working memory in APP/PS1 transgenic mouse model

Background Recent studies have shown that autophagy plays a central role in mesenchymal stem cells (MSCs), and many studies have shown that human umbilical cord MSCs (huMSCs) can treat Alzheimer’s disease (AD) through a variety of mechanisms. However, no studies have looked at the effects of autophagy on neuroprotective function of huMSCs in the AD mouse model. Thus, in this...

Sealing Performance and Optimization of a Subsea Pipeline Mechanical Connector

research interests are mechanical design and reliability design. Shao‑Kai Li born in 1990, is currently a master candidate at College of Mechanical and Electrical Engineering, Harbin Engineering University

MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling

migration. The present study advances our knowledge into understanding the molecular mechanisms underlying the miR-137-regulated VSMCs proliferation. Author Contributions Conceptualization: Jin Pan, Kai Li ... . Data curation: Kai Li, Wei Huang. Formal analysis: Kai Li, Xiaoqing Zhang. Funding acquisition: Jin Pan. Investigation: Kai Li, Wei Huang. Methodology: Wei Huang. Project administration: Wei Huang

Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis

Background. circRNAs are part of the competitive endogenous RNA network, which putatively function as miRNA sponges and play a crucial role in the development of numerous diseases. However, studies of circRNAs in rheumatoid arthritis (RA) disease are limited. This work aims to identify the expression pattern of circRNAs in synovial tissues and their inflammatory regulation...

Clinical value of ALU concentration and integrity index for the early diagnosis of ovarian cancer: A retrospective cohort trial

Conceptualization: Chungen Xing, Kai Li. Data curation: Rong Zhang, Wangyang PU, Shuyun Zhang, Li Chen, Weipei Zhu. Formal analysis: Rong Zhang, Wangyang PU, Shuyun Zhang, Li Chen, Weipei Zhu, Li Xiao, Funding ... acquisition: Rong Zhang, Chungen Xing. Investigation: Rong Zhang, Shuyun Zhang, Li Chen, Weipei Zhu. Methodology: Rong Zhang, Wangyang PU, Li Xiao, Kai Li. Resources: Shuyun Zhang, Li Chen, Weipei Zhu

Association between elevated central venous pressure and outcomes in critically ill patients

Background Some prior studies have shown that elevated mean central venous pressure in certain patient populations and disease processes may lead to poor prognosis. However, these studies failed to generalize the concept of elevated central venous pressure (ECVP) load to all patients in critical care settings because of the limited cases and exclusive cohorts. The aim of the...

Game Equilibrium of False Information Diffusion in Public Crisis on Interpersonal Network

ITM Web of Conferences Game Equilibrium of False Information Crisis on Interpersonal Network Diffusion in Public Kai LI 1 Jia-Jia HAO 0 0 School of Economics and management Yanshan University

Game Equilibrium of False Information Diffusion in Public Crisis on Interpersonal Network

ITM Web of Conferences Game Equilibrium of False Information Crisis on Interpersonal Network Diffusion in Public Kai LI 1 Jia-Jia HAO 0 0 School of Economics and management Yanshan University

The Single Nucleotide Polymorphism rs1014290 of the SLC2A9 Gene Is Associated with Uric Acid Metabolism in Parkinson’s Disease

Individuals with Parkinson’s disease (PD) have lower uric acid levels than those without PD, and the CC genotype and C minor allele of a single nucleotide polymorphism (SNP), rs1014290 of SLC2A9, are associated with lower uric acid levels. We investigated the association of rs1014290 with uric acid metabolism in a cohort of PD cases (220) and controls (110) in a Han Chinese...

Biocapacity optimization in regional planning

Ecological overshoot has been accelerating across the globe. Optimizing biocapacity has become a key to resolve the overshoot of ecological demand in regional sustainable development. However, most literature has focused on reducing ecological footprint but ignores the potential of spatial optimization of biocapacity through regional planning of land use. Here we develop a...

The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact

Osseointegration is the key to implant stability and occlusal support. Biomechanical response and remodeling of peri-implant bone occurs under impact loading. Sclerostin participates in bone formation and resorption through Wnt and RANKL pathways. However the mechanism of microdamage and expression of sclerostin in peri-implant bone under impact load is still unclear. In present...

Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus

, Guangzhou, 510080, ChinaYuan Lin AuthorsSearch for Jiankai Liang in:Nature Research journals • PubMed • Google Scholar Search for Li Guo in:Nature Research journals • PubMed • Google Scholar Search for Kai ... Li in:Nature Research journals • PubMed • Google Scholar Search for Xiao Xiao in:Nature Research journals • PubMed • Google Scholar Search for Wenbo Zhu in:Nature Research journals • PubMed • Google

Decreased FOXP3+ and GARP+ Tregs to neoadjuvant chemotherapy associated with favorable prognosis in advanced gastric cancer

Decreased FOXP3+ and GARP+ Tregs to neoadjuvant chemotherapy associated with favorable prognosis in advanced gastric cancer Kai Li,1 Fuchao Chen,2 Huijuan Xie3 1Department of Pathology, 2Department

Preparation, Pharmacokinetic Profile, and Tissue Distribution Studies of a Liposome-Based Formulation of SN-38 Using an UPLC–MS/MS Method

The application of 7-ethyl-10-hydroxycamptothecin (SN-38) in cancer treatment is limited by its low solubility. This study is to develop a liposome-entrapped formulation of SN-38 (LE-SN38) to solve the obstacle and to evaluate its pharmacokinetic profile in dogs and tissue distribution in mice. LE-SN38 which is more likely to be suitable for large-scale production was prepared by...