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Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV

receptor variable fragment; T-ALL, T cell acute lymphoblastic leukemia; TCR, T cell receptor; TIRF, total internal reflection fluorescence COMPLIANCE WITH ETHICS GUIDELINES Dongfang Liu, Shuo Tian, Kai ... Zhang, Wei Xiong, Ndongala Michel Lubaki, Zhiying Chen, and Weidong Han declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed

Fast-track surgery versus conventional perioperative management of lung cancer-associated pneumonectomy: a randomized controlled clinical trial

Dong 0 Kai Zhang 0 Shouqiang Cao Jian Cui 0 Equal contributors Department of Thoracic Surgery, the Fourth Affiliated Hospital, Harbin Medical University , 37 Yiyuan Street, Nangang District, Harbin

The efficacy and toxicity profile of metronomic chemotherapy for metastatic breast cancer: A meta-analysis

Purpose The current meta-analysis aimed to summarize the available evidence for the efficacy and serious adverse events (AEs) associated with use of metronomic chemotherapy (MCT) in patients with metastatic breast cancer (MBC). Method Electronic databases (PubMed, EMBASE database, Web of Knowledge, and the Cochrane database) were systematically searched for articles related to the ...

Impact of nitrogen fertilization on soil–Atmosphere greenhouse gas exchanges in eucalypt plantations with different soil characteristics in southern China

Nitrogen (N) fertilization is necessary to sustain productivity in eucalypt plantations, but it can increase the risk of greenhouse gas emissions. However, the response of soil greenhouse gas emissions to N fertilization might be influenced by soil characteristics, which is of great significance for accurately assessing greenhouse gas budgets and scientific fertilization in ...

Dexmedetomidine sedation reduces atrial fibrillation after cardiac surgery compared to propofol: a randomized controlled trial

Background Atrial fibrillation occurs frequently in patients following cardiac surgery and can be a cause of increased morbidity and mortality. The use of dexmedetomidine to prevent atrial fibrillation is unclear. The present study was designed to evaluate the effect of dexmedetomidine sedation on the incidence of atrial fibrillation after cardiac surgery. Methods Upon arrival to ...

Three-Dimensional Construction of a Rabbit Anterior Corneal Replacement for Lamellar Keratoplasty

The aim of this study was to construct a rabbit anterior corneal replacement for transplantation using acellular porcine corneal matrix (APCM) and rabbit epithelial or stromal cells. APCM was prepared from fresh porcine cornea treated with 0.5% (wt./vol.) sodium dodecyl sulfate (SDS) solution. The expanded stromal cells were first injected into APCM parallel to its surface and were ...

Solvent: A Key in Digestive Ripening for Monodisperse Au Nanoparticles

This work has mainly investigated the influence of the solvent on the nanoparticles distribution in digestive ripening. The experiments suggested that the solvents played a key role in digestive ripening of Au nanoparticles (Au NPs). For the benzol solvents, the resulting size distribution of Au NPs was inversely related to the solvent polarity. It may be interpreted by the low ...

Risks of developing breast and colorectal cancer in association with incomes and geographic locations in Texas: a retrospective cohort study

Background No study has been conducted to investigate the spatial pattern and association of socioeconomic status (such as income) with breast and colorectal cancer incidence in Texas, United States. This study aimed to determine whether median household income was associated with the risk of developing breast and colorectal cancer in Texas and to identify higher cancer risks by ...

Lipopolysaccharide derived from the digestive tract triggers an inflammatory response in the uterus of mid-lactating dairy cows during SARA

0 Juma Ahamed Abaker 0 Zain ul Aabdin Tianle Xu Hongyu Dai Kai Zhang Xinxin Liu Xiangzhen Shen 0 Equal contributors College of Veterinary Medicine, Nanjing Agricultural University , Nanjing 210095

Experimental studies on the effects of bolt parameters on the bearing characteristics of reinforced rock

Roadways supported by bolts contain support structures that are built into the rock surrounding the roadway, referred to as reinforced rocks in this paper. Using physical model simulation, the paper investigates the bearing characteristics of the reinforced rock under different bolt parameters with incrementally increased load. The experimental results show that the stress at the ...

The presence of Giardia intestinalis in donkeys, Equus asinus, in China

Background Giardia intestinalis is one of the most important zoonotic enteric parasites. As no information regarding prevalence and genotype of G. intestinalis in donkeys (Equus asinus) in China is available, 181 faecal samples from 48 donkeys from Jilin Province, from 104 from Shandong Province and from 29 from Liaoning Province were examined between May and December 2015. ...

Current concepts in odontohypophosphatasia form of hypophosphatasia and report of two cases

Background Hypophosphatasia is a rare inherited disease derived from mutations in tissue non-specific alkaline phosphatase genes, with typical oral symptoms including short root anomaly and dysplasia of dentin or cementum. Case presentation Two young female patients presented with short root anomaly with a history of premature loss of deciduous and/or permanent teeth. The ...

Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma

‑Sheng Huang Chao‑Qun Hong TianT‑ian Zhai Lian‑Di Liao WenJ‑ie Lin LiY‑an Xu Kai Zhang En‑Min Li Yu‑Hui Peng 0 0 Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University

A Preliminary Study on Sinus Fungus Ball with MicroCT and X-Ray Fluorescence Technique

Background Sinus fungus ball, an accumulation of fungal dense concretions, is a common disease in practice, and might cause fatal complications or lead to death once converted into invasive type. Early preoperative diagnosis of this disease can lead to appropriate treatment for patients and prevent multiple surgical procedures. Up to now, the diagnostic criteria of sinus fungus ...

Rumen-derived lipopolysaccharide enhances the expression of lingual antimicrobial peptide in mammary glands of dairy cows fed a high-concentrate diet

Background Long-term high-concentrate diet (HCD) feeding can cause subacute ruminal acidosis in cows and subsequently trigger systemic inflammatory and immune responses. Therefore, we conducted the present study in which twelve lactating cows installed with ruminal fistula were randomly assigned to the HCD group (forage:concentrate = 4:6, n = 6) or the low-concentrate diet (LCD) ...

The Timing of Raf/ERK and AKT Activation in Protecting PC12 Cells against Oxidative Stress

Acute brain injuries such as ischemic stroke or traumatic brain injury often cause massive neural death and irreversible brain damage with grave consequences. Previous studies have established that a key participant in the events leading to neural death is the excessive production of reactive oxygen species. Protecting neuronal cells by activating their endogenous defense ...

Association between Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk: A Meta-Analysis of 39 Studies

Background The associations between vitamin D receptor (VDR) gene polymorphisms and breast cancer risk were comprehensively investigated to clarify issues that remain controversial. Methodology/Principal Findings An electronic search was conducted of several databases, including PubMed, the Cochrane library, Web of Science, EMBASE, CBM and CNKI, for papers that describe the ...