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Downregulation of MiR-31 stimulates expression of LATS2 via the hippo pathway and promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma

Dysregulation of miRNAs is associated with cancer development by coordinately suppressing abundant target genes. Emerging evidence indicates that miR-31 plays a dual role in tumorigenicity. However, whether miR-31 plays as an oncogene in esophageal squamous cell carcinoma (ESCC) and the potential target molecules are still unclear. MiR-31 role in ESCC was investigated and an ...

Effects of biomass reducing agent on magnetic properties and phase transformation of Baotou low-grade limonite during magnetizing-roasting

: Hui juan Luo. Investigation: Wen chao Guo. Methodology: Wen fei Wu. Project administration: Kai Zhang. Software: Zhi jun Gong. Supervision: Bao wei Li. 1. Bing HU , Huang ZC , Tao J , Xia W , Zhang

The efficacy of tranexamic acid using oral administration in total knee arthroplasty: a systematic review and meta-analysis

Total knee arthroplasty (TKA) is gradually regarded as an effective choice for end-stage osteoarthritis or rheumatic arthritis. In the past, the management of tranexamic acid (TXA) using intravenous injection or topical application has been extensively researched. However, several studies have reported that oral TXA has an effect on blood loss. Therefore, a meta-analysis should be ...

Fast-track surgery versus conventional perioperative management of lung cancer-associated pneumonectomy: a randomized controlled clinical trial

Dong 0 Kai Zhang 0 Shouqiang Cao Jian Cui 0 Equal contributors Department of Thoracic Surgery, the Fourth Affiliated Hospital, Harbin Medical University , 37 Yiyuan Street, Nangang District, Harbin

Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV

receptor variable fragment; T-ALL, T cell acute lymphoblastic leukemia; TCR, T cell receptor; TIRF, total internal reflection fluorescence COMPLIANCE WITH ETHICS GUIDELINES Dongfang Liu, Shuo Tian, Kai ... Zhang, Wei Xiong, Ndongala Michel Lubaki, Zhiying Chen, and Weidong Han declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed

The efficacy and toxicity profile of metronomic chemotherapy for metastatic breast cancer: A meta-analysis

Purpose The current meta-analysis aimed to summarize the available evidence for the efficacy and serious adverse events (AEs) associated with use of metronomic chemotherapy (MCT) in patients with metastatic breast cancer (MBC). Method Electronic databases (PubMed, EMBASE database, Web of Knowledge, and the Cochrane database) were systematically searched for articles related to the ...

Impact of nitrogen fertilization on soil–Atmosphere greenhouse gas exchanges in eucalypt plantations with different soil characteristics in southern China

Nitrogen (N) fertilization is necessary to sustain productivity in eucalypt plantations, but it can increase the risk of greenhouse gas emissions. However, the response of soil greenhouse gas emissions to N fertilization might be influenced by soil characteristics, which is of great significance for accurately assessing greenhouse gas budgets and scientific fertilization in ...

Dexmedetomidine sedation reduces atrial fibrillation after cardiac surgery compared to propofol: a randomized controlled trial

Background Atrial fibrillation occurs frequently in patients following cardiac surgery and can be a cause of increased morbidity and mortality. The use of dexmedetomidine to prevent atrial fibrillation is unclear. The present study was designed to evaluate the effect of dexmedetomidine sedation on the incidence of atrial fibrillation after cardiac surgery. Methods Upon arrival to ...

Risks of developing breast and colorectal cancer in association with incomes and geographic locations in Texas: a retrospective cohort study

Background No study has been conducted to investigate the spatial pattern and association of socioeconomic status (such as income) with breast and colorectal cancer incidence in Texas, United States. This study aimed to determine whether median household income was associated with the risk of developing breast and colorectal cancer in Texas and to identify higher cancer risks by ...

Three-Dimensional Construction of a Rabbit Anterior Corneal Replacement for Lamellar Keratoplasty

The aim of this study was to construct a rabbit anterior corneal replacement for transplantation using acellular porcine corneal matrix (APCM) and rabbit epithelial or stromal cells. APCM was prepared from fresh porcine cornea treated with 0.5% (wt./vol.) sodium dodecyl sulfate (SDS) solution. The expanded stromal cells were first injected into APCM parallel to its surface and were ...

Experimental studies on the effects of bolt parameters on the bearing characteristics of reinforced rock

Roadways supported by bolts contain support structures that are built into the rock surrounding the roadway, referred to as reinforced rocks in this paper. Using physical model simulation, the paper investigates the bearing characteristics of the reinforced rock under different bolt parameters with incrementally increased load. The experimental results show that the stress at the ...

Different Levels of CEA, CA153 and CA125 in Milk and Benign and Malignant Nipple Discharge

Background The aim of this study was to assess the diagnostic values of three breast tumor markers (i.e., CEA, CA153 and CA125) in milk and nipple discharge in the prediction of different breast diseases diagnoses. Methods Three hundred thirty-six patients (96 breast cancer and 240 benign disease patients) with nipple discharge and a control group of 56 healthy parturient ...

Solvent: A Key in Digestive Ripening for Monodisperse Au Nanoparticles

This work has mainly investigated the influence of the solvent on the nanoparticles distribution in digestive ripening. The experiments suggested that the solvents played a key role in digestive ripening of Au nanoparticles (Au NPs). For the benzol solvents, the resulting size distribution of Au NPs was inversely related to the solvent polarity. It may be interpreted by the low ...

Lipopolysaccharide derived from the digestive tract triggers an inflammatory response in the uterus of mid-lactating dairy cows during SARA

0 Juma Ahamed Abaker 0 Zain ul Aabdin Tianle Xu Hongyu Dai Kai Zhang Xinxin Liu Xiangzhen Shen 0 Equal contributors College of Veterinary Medicine, Nanjing Agricultural University , Nanjing 210095

A Preliminary Study on Sinus Fungus Ball with MicroCT and X-Ray Fluorescence Technique

Background Sinus fungus ball, an accumulation of fungal dense concretions, is a common disease in practice, and might cause fatal complications or lead to death once converted into invasive type. Early preoperative diagnosis of this disease can lead to appropriate treatment for patients and prevent multiple surgical procedures. Up to now, the diagnostic criteria of sinus fungus ...