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Preface to the special issue on big data search and mining

City, UT , USA 2 Soochow University , Suzhou , China 3 Kai Zheng, Feifei Li and Kyuseok Shim 26/02/2017 We are delighted to present this special issue of World Wide Web on Big Data Search and Mining

Investigation of rheo-diecasting mold filling of semi-solid A380 aluminum alloy slurry

The rheo-diecasting mold filling capacity and the microstructure of the semi-solid A380 aluminum alloy slurry were investigated. The results show that the mold filling capacity was strengthened with increasing pouring temperature or increasing injection pressure. Under certain process parameters, the mold cavity was fully filled. However, the mold filling capacity decreased with ...

Traditional Chinese medicine combination therapy for patients with steroid-dependent ulcerative colitis: study protocol for a randomized controlled trial

Background Approximately 20% of patients with ulcerative colitis become steroid dependent. Azathioprine is recommended in steroid-dependent ulcerative colitis, but its side effects limit its use. Chinese herbal medicine has been widely used to treat ulcerative colitis in China. However, its effectiveness in steroid-dependent patients has not been evaluated. This study aims to ...

Compensatory variances of drug-induced hepatitis B virus YMDD mutations

Although the drug-induced mutations of HBV have been ever documented, the evolutionary mechanism is still obscure. To deeply reveal molecular characters of HBV evolution under the special condition, here we made a comprehensive investigation of the molecular variation of the 3432 wild-type sequences and 439 YMDD variants from HBV genotype A, B, C and D, and evaluated the co-variant ...

Landmark-Based Route Recommendation with Crowd Intelligence

Route recommendation is one of the most widely used location-based services nowadays, as it is vital for nice-driving experience and smooth public traffic. Given a pair of user-specified origin and destination, a route recommendation service aims to provide users with the routes of the best travelling experience according to given criteria. However, even the routes recommended by ...

Surgical treatment for pelvic giant cell tumor: a multi-center study

Background The purpose of this study was to discuss the clinical results which related to the location of giant cell tumors (GCTs) in the pelvis so as to determine the ideal surgical treatment protocol. Methods We report 29 cases who accepted surgical treatment from five clinical centers during the last 12 years. All patients were divided into three groups according to tumor ...

Correlation between impedance cardiography and 6 min walk distance in atrial fibrillation patients

Kai Zheng Wei-Wei Yu Xiao-Fen Wu Tao Mi Cun-Tai Zhang Hong-Lian Zhou 0 Equal contributors Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and

Health-Related Quality of Life in Chinese Patients with Mild and Moderately Active Ulcerative Colitis

Background Ulcerative colitis (UC) impairs the health-related quality of life (HRQOL). The difference in HRQOL between patients with mild and moderately active UC is not well-defined. Few studies have been conducted to explore the factors that influence HRQOL in Chinese patients. Our study aims were to (1) compare HRQOL of mildly active UC patients with moderate patients; (2) ...

Successful management of early recurrence after surgery for primary rib osteosarcoma in an adult

Guowu Xu 0 Kai Zheng 0 0 Department of Cardiothoracic Surgery, Tianjin Medical University General Hospital , Tianjin, China Primary osteosarcoma is a common malignant bone tumour that principally

Study on the non-contact FBG vibration sensor and its application

A non-contact vibration sensor based on the fiber Bragg grating (FBG) sensor has been presented, and it is used to monitor the vibration of rotating shaft. In the paper, we describe the principle of the sensor and make some experimental analyses. The analysis results show that the sensitivity and linearity of the sensor are −1.5 pm/μm and 4.11% within a measuring range of 2 mm–2.6 ...

Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway

Background Acute myeloid leukemia (AML) is initiated and maintained by a subset of self-renewing leukemia stem cells (LSCs), which contribute to the progression, recurrence and therapeutic resistance of leukemia. However, the mechanisms underlying the maintenance of LSCs drug resistance have not been fully defined. In this study, we attempted to elucidate the mechanisms of LSCs ...

Heat-Shock Protein 90 Promotes Nuclear Transport of Herpes Simplex Virus 1 Capsid Protein by Interacting with Acetylated Tubulin

Although it is known that inhibitors of heat shock protein 90 (Hsp90) can inhibit herpes simplex virus type 1 (HSV-1) infection, the role of Hsp90 in HSV-1 entry and the antiviral mechanisms of Hsp90 inhibitors remain unclear. In this study, we found that Hsp90 inhibitors have potent antiviral activity against standard or drug-resistant HSV-1 strains and viral gene and protein ...

Silencing Herpes Simplex Virus Type 1 Capsid Protein Encoding Genes by siRNA: A Promising Antiviral Therapeutic Approach

Herpes simplex virus type 1 (HSV-1), a member of the herpesviridae, causes a variety of human viral diseases globally. Although a series of antiviral drugs are available for the treatment of infection and suppression of dissemination, HSV-1 remains highly prevalent worldwide. Therefore, the development of novel antiviral agents with different mechanisms of action is a matter of ...

Novel intronic microRNA represses zebrafish myf5 promoter activity through silencing dickkopf-3 gene

A strong, negative cis-element located at the first intron +502/+835 (I300) of zebrafish myf5 has been reported. To elucidate the molecular mechanism underlying this repression network, we microinjected zebrafish single-cell embryos with I300 RNA, resulting in the dramatic reduction of luciferase activity driven by the myf5 promoter. Within this I300 segment, we identified an ...

Integrating an internet-mediated walking program into family medicine clinical practice: a pilot feasibility study

Background Regular participation in physical activity can prevent many chronic health conditions. Computerized self-management programs are effective clinical tools to support patient participation in physical activity. This pilot study sought to develop and evaluate an online interface for primary care providers to refer patients to an Internet-mediated walking program called ...