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9 papers found.
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Rates of glycaemic deterioration in a real-world population with type 2 diabetes

Aims/hypothesis There is considerable variability in how diabetes progresses after diagnosis. Progression modelling has largely focused on ‘time to failure’ methods, yet determining a ‘coefficient of failure’ has many advantages. We derived a rate of glycaemic deterioration in type 2 diabetes, using a large real-world cohort, and aimed to investigate the clinical, biochemical...

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes

Aims/hypothesis There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data integration to determine the validity of published evidence...

Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents

Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents Adem Yesuf Dawed, Kaixin Zhou, Ewan Robert Pearson  Division of Cardiovascular and Diabetes Medicine, Medical

Clinical and Genetic Determinants of Progression of Type 2 Diabetes: A DIRECT Study

OBJECTIVE To identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between idividuals following diagnosis of type 2 diabetes.

htSNPer1.0: software for haplotype block partition and htSNPs selection

Background There is recently great interest in haplotype block structure and haplotype tagging SNPs (htSNPs) in the human genome for its implication on htSNPs-based association mapping strategy for complex disease. Different definitions have been used to characterize the haplotype block structure in the human genome, and several different performance criteria and algorithms have...

LDA—a java-based linkage disequilibrium analyzer

Summary: We describe an integrated java-based program that provides elaborate graphic and plain-text output of pairwise linkage disequilibrium (LD) analysis of single nucleotide polymorphisms genotypic data. It is most suitable for molecular geneticists, who are focusing on LD measures estimation, statistical significance test and extent prediction. Availability: The software is...

The Effect of Haplotype-Block Definitions on Inference of Haplotype-Block Structure and htSNPs Selection

It has been recently suggested that the human genome is organized as a series of haplotype blocks, and efforts to create a genome-wide haplotype map are already underway. Several computational algorithms have been proposed to partition the genome. However, little is known about their behaviors in relation to the haplotype-block partitioning and haplotype-tagging SNPs selection...

Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study

Kaixin Zhou Louise A. Donnelly Charlotte H. Kimber Peter T. Donnan Alex S.F. Doney Graham Leese Andrew T. Hattersley Mark I. McCarthy Andrew D. Morris Colin N.A. Palmer Ewan R. Pearson OBJECTIVE

Haplotype Structure and Evidence for Positive Selection at the Human IL13 Locus

Interleukin-13 (IL13) is believed to play an important role in the pathogenesis of atopy and allergic asthma. To better understand genetic variation at the IL13 locus, we resequenced a 5.1-kb genomic region spanning the entire locus and identified 26 single-nucleotide polymorphisms (SNPs) in 74 individuals from three major populations—Chinese, Caucasian, and African. Our survey...