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5 papers found.
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Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger

Background Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited information is available on the pharmacokinetic properties of antimalarial drugs in this vulnerable population. We assessed artemether-lumefantrine (AL) clinical efficacy in children with SAM compared to those without...

A multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study

Background Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severely malnourished children are systematically excluded. Few studies have assessed the efficacy of chloroquine, sulfadoxine-pyrimethamine and quinine in severe acute malnourished children...

Reduced Variation Around Drug-Resistant dhfr Alleles in African Plasmodium falciparum

Karen Barnes 0 London School of Hygiene and Tropical Medicine, Pathogen Molecular Biology Unit, Department of Infectious Tropical Diseases , London , United Kingdom ; University of Morogoro, Department of

The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

Sue J Lee Kasia Stepniewska Nicholas Anstey Elizabeth Ashley Karen Barnes Tran Quang Binh Umberto D'Alessandro Nicholas PJ Day Peter J de Vries Grant Dorsey Jean- Paul Guthmann Mayfong