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Tuberculosis Case Fatality and Other Causes of Death among Multidrug-Resistant Tuberculosis Patients in a High HIV Prevalence Setting, 2000-2008, South Africa

Introduction South Africa has the highest reported rates of multi-drug resistant TB in Africa, typified by poor treatment outcomes, attributable mainly to high default and death rates. Concomitant HIV has become the strongest predictor of death among MDR-TB patients, while anti-retroviral therapy (ART) has dramatically reduced mortality. TB Case fatality rate (CFR) is an...

Serious Treatment Related Adverse Drug Reactions amongst Anti-Retroviral Naïve MDR-TB Patients

Background Globally treatment outcomes for multidrug-resistant Mycobacterium tuberculosis (MDR-TB) remain poor and this is compounded by high drug toxicity. Little is known about the influence of adverse drug reactions (ADRs) on treatment outcomes in South Africa. Methods We evaluated the impact of severe ADRs among a prospective cohort of MDR-TB patients in South Africa (2000...

Treatment Outcomes of Patients With Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis According to Drug Susceptibility Testing to First- and Second-line Drugs: An Individual Patient Data Meta-analysis

Alfredo Ponce-de-Leon 11 Kwonjune J. Seung 6 Karen Shean 7 José Sifuentes-Osornio 11 Martie Van der Walt 4 Tjip S. Van der Werf 5 Wing Wai Yew 2 Dick Menzies 1 3 0 The members of the Collaborative Group

Drug-Associated Adverse Events and Their Relationship with Outcomes in Patients Receiving Treatment for Extensively Drug-Resistant Tuberculosis in South Africa

Shean Elizabeth Streicher Elize Pieterson Greg Symons Richard van Zyl Smit Grant Theron Rannakoe Lehloenya Xavier Padanilam Paul Wilcox Tommie C. Victor Paul van Helden Martin Groubusch Robin Warren

Genetic Polymorphism in Mycobacterium tuberculosis Isolates from Patients with Chronic Multidrug-Resistant Tuberculosis

Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem because treatment is complicated, cure rates are well below those for drug-susceptible tuberculosis (TB), and patients may remain infectious for months or years, despite receiving the best available therapy. To gain a better understanding of MDR-TB, we characterized serial isolates recovered from 13 human...