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Search: authors:"Karin Cederbrant"

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HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity

tissue samplings were carried out by the staff from the AstraZeneca animal department (SoÈdertaÈlje, Sweden). Author Contributions Conceptualization: Karin Cederbrant, Johan Jirholt. Formal analysis ... : Hanna Lundgren, Klara Martinsson, Katja Madeyski-Bengtson, Said Havarinasab. Funding acquisition: Karin Cederbrant. Investigation: Hanna Lundgren, Klara Martinsson, Karin Cederbrant. Methodology

The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs

Adverse drug reactions represent a major stumbling block to drug development and those with an immune etiology are the most difficult to predict. We have developed an in vitro T-cell priming culture method using peripheral blood from healthy volunteers to assess the allergenic potential of drugs. The drug metabolite nitroso sulfamethoxazole (SMX-NO) was used as a model drug...

In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

Background Drug-induced liver injury (DILI) is one of the most common adverse reactions leading to product withdrawal post-marketing. Recently, genome-wide association studies have identified a number of human leukocyte antigen (HLA) alleles associated with DILI; however, the cellular and chemical mechanisms are not fully understood. Methods To study these mechanisms, we...