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Gentherapie zur Behandlung von Netzhauterkrankungen

Eine Reihe von Netzhauterkrankungen hat bekannte genetische Ursachen, die prinzipiell durch Gentherapie behandelt werden können. Diese Übersicht stellt das Prinzip und die Besonderheiten der okulären Gentherapie dar, fasst den aktuellen Stand der Forschung bis hin zur klinischen Anwendung zusammen und gibt einen Ausblick auf aktuelle Entwicklungen der Gentherapie am Auge.

Knowledge of vitreomacular traction (VMT) scenarios: Is doing nothing still a beneficial alternative and, if so, when?

, Allergan, Bayer HealthCare, Heidelberg Engineering, Novartis. Spyros Dimopoulos discloses a potential conflict of interest due to travel expenses covered by Alcon. Karl-Ulrich Bartz-Schmidt discloses a

Morphometric Optic Nerve Head Analysis in Glaucoma Patients: A Comparison between the Simultaneous Nonmydriatic Stereoscopic Fundus Camera (Kowa Nonmyd WX3D) and the Heidelberg Scanning Laser Ophthalmoscope (HRT III)

Ophthalmoscope (HRT III) Siegfried Mariacher,1 Stephanie Hipp,2 Robert Wirthky,3 Gunnar Blumenstock,4 Karl-Ulrich Bartz-Schmidt,3 Focke Ziemssen,3 Ulrich Schiefer,3,5,6 Bogomil Voykov,3 and Kai Januschowski1,3

Using a slit lamp-mounted digital high-speed camera for dynamic observation of phakic lenses during eye movements: a pilot study

Using a slit lamp-mounted digital high-speed camera for dynamic observation of phakic lenses during eye movements: a pilot study Martin Alexander Leitritz, Focke Ziemssen, Karl Ulrich Bartz-Schmidt

Descemet membrane endothelial keratoplasty in cases with existing scleral-sutured and iris-sutured intraocular lenses

Background To report two cases of Descemet Membrane Endothelial Keratoplasty (DMEK) in patients with existing scleral-fixated and iris-fixated intraocular lenses (sf-IOL and if-IOL, respectively). Case presentation DMEK procedures were performed on a 49-year-old woman with a pre-existing sf-IOL (case 1) and a 69-year-old woman with a pre-existing if-IOL (case 2) in order to treat...

Extraocular Surgical Approach for Placement of Subretinal Implants in Blind Patients: Lessons from Cochlear-Implants

In hereditary retinal diseases photoreceptors progressively degenerate, often causing blindness without therapy being available. Newly developed subretinal implants can substitute functions of photoreceptors. Retina implant extraocular surgical technique relies strongly on cochlear-implant know-how. However, a completely new surgical approach providing safe handling of the...

Response to: Non-invasive electrical brain stimulation induces vision restoration in patients with visual pathway damage

Florian Gekeler Karl Ulrich Bartz-Schmidt 0 ) Ophthalmology, University Hospital , Schleichstrasse 12-16, Tuebingen 72076, Germany Dear Mrs. Gall, Mrs. Antal, and Mr. Sabel, Thank you for

Electrical stimulation — a therapeutic strategy for retinal and optic nerve disease?

Florian Gekeler Karl Ulrich Bartz-Schmidt - Since Galvanis experiments with frog legs in 1791, we know that neural tissue can be readily excited by electrical currents. Doctors have utilized the

Transcorneal Electrical Stimulation in Patients with Retinal Artery Occlusion: A Prospective, Randomized, Sham-Controlled Pilot Study

Introduction The purpose of this study was to investigate the safety and efficacy of transcorneal electrical stimulation (TES) in patients suffering from retinal artery occlusion (RAO). Methods Twelve patients with central and one patient with branch RAO (age 25–84 years, median 74 years) were enrolled in this prospective, randomized, sham-controlled study. RAO was diagnosed 10...

Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS

This study aims at substituting the essential functions of photoreceptors in patients who are blind owing to untreatable forms of hereditary retinal degenerations. A microelectronic neuroprosthetic device, powered via transdermal inductive transmission, carrying 1500 independent microphotodiode-amplifier-electrode elements on a 9 mm2 chip, was subretinally implanted in nine blind...

Subretinal electronic chips allow blind patients to read letters and combine them to words

Ulrich Bartz-Schmidt , Heval Benav, Dorothea Besch, Anna Bruckmann, Veit-Peter Gabel, Florian Gekeler, Udo Greppmaier, Alex Harscher, Steffen Kibbel, Johannes Koch, Akos Kusnyerik, Tobias Peters, Katarina