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Search: authors:"Katharina Dannhausen"

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Mikroglia und Immuntherapien bei degenerativen Netzhauterkrankungen

Netzhauterkrankungen 0 Lehrstuhl für Experimentelle Immunologie des Auges, Zentrum für Augenheilkunde , Uniklinik Köln, Köln , Deutschland Marcus Karlstetter · Katharina Dannhausen · Thomas Langmann Hintergrund

Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator

Background Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The polymorphism rs10490924 in the ARMS2 gene is highly associated with AMD and linked to an indel mutation (del443ins54), the latter inducing mRNA instability. At present, the function of the ARMS2 protein, the exact cellular sources in the retina and the biological...