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Comment on: The ORIGIN Trial Investigators. Characteristics Associated With Maintenance of Mean A1C <6.5% in People With Dysglycemia in the ORIGIN Trial. Diabetes Care 2013;36:2915–2922

to the small numbers of trials (only three trials with a mean baseline A1C ,8%). Keeping A1C at any personalized target is more likely in type 2 diabetic people with lower baseline A1C. KATHERINE ... ESPOSITO, MD, PHD1 DARIO GIUGLIANO, MD, PHD2 c c c c c c c c c c c c c c c c c c c c c c c c References 1. The ORIGIN Trial Investigators. Character istics associated with maintenance of mean A1C ,6.5% in

Comment on: Wheeler et al. Macronutrients, Food Groups, and Eating Patterns in the Management of Diabetes: A Systematic Review of the Literature, 2010. Diabetes Care 2012;35:434–445

KATHERINE ESPOSITO 0 DARIO GIUGLIANO 0 0 c c c c c c c c c c c c c c c c c c c c c c c c References 1. Wheeler ML, Dunbar SA, Jaacks LM, et al. Macronutrients, food groups, and eating patterns in the

New guidelines for metabolic targets in diabetes: clinician’s opinion does matter

Evidence-based medicine replaced eminence-based medicine as a way to manage unavoidable clinical uncertainty. Moving away from “one-size-fits-all” medicine, personalized medicine seemed to have the potential of tailoring therapies to subsets of patients. Despite the rapid progress in drug development for diabetes, it is still challenging to achieve good glycemic control in a...

Cardiovascular guidelines: separate career may help attenuate controversy

The release of recent guidelines for high cholesterol, hypertension and diabetes in the U.S. has been accompanied by great noise and concerns, both in the academic circuits and the lay press. For persons aged 40 to75 years, with LDL cholesterol levels between 70–189 mg/dL and 7.5% or higher estimated 10-year risk, the peril of a global “statinization” has been advocated...

Comment on Tay et al. A Very Low-Carbohydrate, Low–Saturated Fat Diet for Type 2 Diabetes Management: A Randomized Trial. Diabetes Care 2014;37:2909–2918

Dario Giugliano 2 Katherine Esposito 0 0 Diabetes Unit, University Hospital at the Second University of Naples , Naples , Italy 1 IOS and Coleman Medicina Futura Medical Center, Centro Direzionale

Comment on: Wing et al. Effect of Intensive Lifestyle Intervention on Sexual Dysfunction in Women With Type 2 Diabetes: Results From an Ancillary Look AHEAD Study. Diabetes Care 2013;36:2937–2944

KATHERINE ESPOSITO, MD, PHD2 c c c c c c c c c c c c c c c c c c c c c c c c References 1. Wing RR, Bond DS, Gendrano IN 3rd, et al. Effect of intensive lifestyle intervention on sexual dysfunction in women

Role of prophylactic central compartment lymph node dissection in clinically N0 differentiated thyroid cancer patients: analysis of risk factors and review of modern trends

In the last years, especially thanks to a large diffusion of ultrasound-guided FNBs, a surprising increased incidence of differentiated thyroid cancer (DTC), “small” tumors and microcarcinomas have been reported in the international series. This led endocrinologists and surgeons to search for “tailored” and “less aggressive” therapeutic protocols avoiding risky morbidity and...

Comment on Home et al. Predictive and Explanatory Factors of Change in HbA1c in a 24-Week Observational Study of 66,726 People With Type 2 Diabetes Starting Insulin Analogs. Diabetes Care 2014;37:1237–1245

difference in HbA1c response was 0.7% between lower and middle and 1% between middle and higher baseline HbA1c levels. Ironically, the median duration of the studies included in our analysis (3) was Katherine ... Esposito,1 Maria Ida Maiorino,2 Giuseppe Bellastella,2 Michela Petrizzo,1 and Dario Giugliano2 24 weeks (interquartile range 2026 weeks), exactly the same as the A1chieve study. This was reassuring as

The Effects of a Mediterranean Diet on the Need for Diabetes Drugs and Remission of Newly Diagnosed Type 2 Diabetes: Follow-up of a Randomized Trial

OBJECTIVE To assess the long-term effects of dietary interventions on glycemic control, need for diabetes medications, and remission of type 2 diabetes.

Personalized therapy algorithms for type 2 diabetes: a phenotype-based approach

Personalized therapy algorithms for type 2 diabetes: a phenotype-based approach Antonio Ceriello,1,2 Marco Gallo,3 Riccardo Candido,4 Alberto De Micheli,5 Katherine Esposito,6 Sandro Gentile,6 ... Biomèdica en Red de Diabetes y enfermedades Metabolicas Asociadas , Barcelona , Spain 3 Department of endocrinology, Hospital Clinic de Barcelona, institut d'investigacions Biomèdiques 4 Katherine esposito 5

The protective effect of the Mediterranean diet on endothelial resistance to GLP-1 in type 2 diabetes: a preliminary report

Background In type 2 diabetes, acute hyperglycemia worsens endothelial function and inflammation,while resistance to GLP-1 action occurs. All these phenomena seem to be related to the generation of oxidative stress. A Mediterranean diet, supplemented with olive oil, increases plasma antioxidant capacity, suggesting that its implementation can have a favorable effect on the...

Metabolic Syndrome and Risk of Cancer: A systematic review and meta-analysis

KATHERINE ESPOSITO PHD PAOLO CHIODINI PHD ANNAMARIA COLAO ANDREA LENZI DARIO GIUGLIANO PHD OBJECTIVEdAvailable evidence supports the emerging hypothesis that metabolic syndrome may be associated

Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy – focus on alogliptin

Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy – focus on alogliptin Annalisa Capuano,1 Liberata Sportiello,1 Maria Ida Maiorino,2 Francesco Rossi,1 Dario Giugliano,2 Katherine Esposito3 1Department of Experimental Medicine, 2Department of Medical, Surgical, Neurological, Metabolic Sciences, and Geriatrics, 3Department of Clinical and Experimental Medicine and...