and Cancer Research Program, Hunter Medical Research Institute , New Lambton Heights, NSW , Australia 2 Edited by: Gabi U. Dachs, University of Otago , Christchurch , New Zealand 3 Kathryn A. Skelding 4 ... contributed equally to this work ‡ORCID: Olivia G. Taylor orcid.org/0000-0002-2850-6551 Joshua S. Brzozowski orcid.org/0000-0001-5508-5257 Kathryn A. Skelding orcid.org/0000-0002-9230-3417t Specialty
The importance of Ca2+ signalling in key events of cancer cell function and tumour progression, such as proliferation, migration, invasion and survival, has recently begun to be appreciated. Many cellular Ca2+-stimulated signalling cascades utilise the intermediate, calmodulin (CaM). The Ca2+/CaM complex binds and activates a variety of enzymes, including members of the...
Extracellular vesicles (EVs) are produced and secreted from most cells of the body and can be recovered in biological fluids. Although there has been extensive characterisation of the protein and nucleic acid component of EVs, their lipidome has received little attention and may represent a unique and untapped source of biomarkers for prostate cancer diagnosis and prognosis. EVs...
To facilitate intercellular communication, cells release nano-sized, extracellular vesicles (EVs) to transfer biological cargo to both local and distant sites. EVs are enriched in tetraspanins, two of which (CD9 and CD151) have altered expression patterns in many solid tumours, including prostate cancer, as they advance toward metastasis. We aimed to determine whether EVs from...