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Search: authors:"Katrin Paeschke"

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Mms1 is an assistant for regulating G-quadruplex DNA structures

Groningen, University of Groningen , 9713 AV Groningen , The Netherlands 1 Communicated by M. Kupiec 2 Katrin Paeschke The preservation of genome stability is fundamental for every cell. Genomic integrity is

The Pif1 Helicase, a Negative Regulator of Telomerase, Acts Preferentially at Long Telomeres

Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB). Here, we report that the association of the telomerase subunits Est2 and Est1 at a DSB was increased in the absence of Pif1, as it is at ...

G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae

G-quadruplex DNA is a four-stranded DNA structure formed by non-Watson-Crick base pairing between stacked sets of four guanines. Many possible functions have been proposed for this structure, but its in vivo role in the cell is still largely unresolved. We carried out a genome-wide survey of the evolutionary conservation of regions with the potential to form G-quadruplex DNA ...