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147 papers found.
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Accordance to the Dietary Approaches to Stop Hypertension diet pattern and cardiovascular disease in a British, population-based cohort

The dietary approaches to stop hypertension (DASH) diet could be an important population-level strategy to reduce cardiovascular disease (CVD) in the UK, but there is little UK-based evidence on this diet pattern in relation to CVD risk. We tested whether dietary accordance with DASH was associated with risk of CVD in a population-based sample of 23,655 UK adults. This...

Weight change and 15 year mortality: results from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort study

Studies have reported a higher mortality risk associated with weight loss, particularly in middle-aged and older adults, although some of these studies did find that gaining weight was also associated with an increased mortality risk. We examined changes in weight in relation to mortality in a prospective population-based cohort study of men and women, resident in Norfolk, UK...

Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries

J. Key 20 & Kay-Tee Khaw 21 & Cecilie Kyrø 22 & Francesca Romana Mancini 13 & Elena Molina-Portillo 7,23 & Neil Murphy 15 & Peter M. Nilsson 24 & N. Charlotte Onland-Moret 25 & Domenico Palli 26

Association between urinary biomarkers of total sugars intake and measures of obesity in a cross-sectional study

Obesity is an important modifiable risk factor for chronic diseases. While there is increasing focus on the role of dietary sugars, there remains a paucity of data establishing the association between sugar intake and obesity in the general public. The objective of this study was to investigate associations of estimated sugar intake with odds for obesity in a representative...

Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk study

Background Despite convincing evidence in the Mediterranean region, the cardiovascular benefit of the Mediterranean diet is not well established in non-Mediterranean countries and the optimal criteria for defining adherence are unclear. The population attributable fraction (PAF) of adherence to this diet is also unknown. Methods In the UK-based EPIC-Norfolk prospective cohort, we...

Fracture Risk in Relation to Serum 25-Hydroxyvitamin D and Physical Activity: Results from the EPIC-Norfolk Cohort Study

Vitamin D deficiency and physical inactivity have been associated with bone loss and fractures, but their combined effect has scarcely been studied either in younger or older adults. Therefore, we aimed to assess the associations between physical activity, age and 25-hydroxyvitamin D (25(OH)D) status separately and in combination with the incidence of fracture risk in the EPIC...

Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study

Background Significant fatigue is a frequent reason for seeking medical advice in the general population. Patients, however, commonly feel their complaint is ignored. This situation may be because clinicians perceive fatigue to be benign, unrelated to traditional biomedical outcomes such as premature mortality. The present study aimed to investigate whether an association between...

Cross Sectional Associations between Socio-Demographic Factors and Cognitive Performance in an Older British Population: The European Investigation of Cancer in Norfolk (EPIC-Norfolk) Study

Background Cognition covers a range of abilities, such as memory, response time and language, with tests assessing either specific or generic aspects. However differences between measures may be observed within the same individuals. Objective To investigate the cross-sectional association of cognitive performance and socio-demographic factors using different assessment tools...

Repeat Cardiovascular Risk Assessment after Four Years: Is There Improvement in Risk Prediction?

Background Framingham risk equations are widely used to predict cardiovascular disease based on health information from a single time point. Little is known regarding use of information from repeat risk assessments and temporal change in estimated cardiovascular risk for prediction of future cardiovascular events. This study was aimed to compare the discrimination and risk...

Longitudinal association of C-reactive protein and Haemoglobin A1c over 13 years: the European Prospective Investigation into Cancer - Norfolk study

Background Type-2 diabetes is associated with systemic inflammation and higher C-reactive protein (CRP) levels. However, the longitudinal association of CRP and haemoglobin-A1c (HbA1c) has not been described in large prospective studies. Understanding such associations may shed light on the role of inflammation in development of type-2 diabetes and its complications such as...

Crowdsourcing as a Screening Tool to Detect Clinical Features of Glaucomatous Optic Neuropathy from Digital Photography

Aim Crowdsourcing is the process of simplifying and outsourcing numerous tasks to many untrained individuals. Our aim was to assess the performance and repeatability of crowdsourcing in the classification of normal and glaucomatous discs from optic disc images. Methods Optic disc images (N = 127) with pre-determined disease status were selected by consensus agreement from grading...

Prospective associations and population impact of sweet beverage intake and type 2 diabetes, and effects of substitutions with alternative beverages

Aims/hypothesis This study aimed to evaluate the association of types of sugar-sweetened beverages (SSB) (soft drinks, sweetened-milk beverages, sweetened tea/coffee), artificially sweetened beverages (ASB) and fruit juice with incident type 2 diabetes and determine the effects of substituting non-SSB for SSB and the population-attributable fraction of type 2 diabetes due to...

A proposed panel of biomarkers of healthy ageing

Background There is no criterion reference for assessing healthy ageing and this creates difficulties when conducting and comparing research on ageing across studies. A cardinal feature of ageing is loss of function which translates into wide-ranging consequences for the individual and for family, carers and society. We undertook comprehensive reviews of the literature searching...

Distribution of lipid parameters according to different socio-economic indicators- the EPIC-Norfolk prospective population study

Shamarina Shohaimi 0 Matthijs S Boekholdt Robert Luben Nick J Wareham Kay-Tee Khaw 0 Department of Biology, Faculty of Science, Universiti Putra Malaysia , Serdang, Selangor 43400 , Malaysia

Body Mass Index, Smoking, and Alcohol and Risks of Barrett’s Esophagus and Esophageal Adenocarcinoma: A UK Prospective Cohort Study

Background The timing of the risk factors cigarette smoking, alcohol and obesity in the development of Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) is unclear. Aims To investigate these exposures in the aetiology of BE and EAC in the same population. Methods The cohort included 24,068 men and women, aged 39–79 years, recruited between 1993 and 1997 into the...

Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

-Dolores Chirlaque Eva Ardanaz Miren Dorronsoro Tim Key Kay-Tee Khaw Sabina Rinaldi Laure Dossus Marc Gunter Melissa A. Merritt Elio Riboli Rudolf Kaaks 0 0 Division of Cancer Epidemiology, German Cancer

Flavonoid Intake in European Adults (18 to 64 Years)

Background Flavonoids are a group of phenolic secondary plant metabolites that are ubiquitous in plant-based diets. Data from anthropological, observational and intervention studies have shown that many flavonoids are bioactive. For this reason, there is an increasing interest in investigating the potential health effects of these compounds. The translation of these findings into...

Longitudinal Association of C-Reactive Protein and Lung Function Over 13 Years: The EPIC-Norfolk Study

Kingdom (Sara Ahmadi-Abhari, Stephen Kaptoge, Robert N. Luben, Kay-Tee Khaw); and Medical Research Council Epidemiology Unit, Institute of Metabolic Sciences, Cambridge, United Kingdom (Nicholas J. Wareham

Tinned Fruit Consumption and Mortality in Three Prospective Cohorts

Dietary recommendations to promote health include fresh, frozen and tinned fruit, but few studies have examined the health benefits of tinned fruit. We therefore studied the association between tinned fruit consumption and mortality. We followed up participants from three prospective cohorts in the United Kingdom: 22,421 participants from the European Prospective Investigation...

Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary

Laura M. O'Connor Marleen A. H. Lentjes Robert N. Luben Kay-Tee Khaw Nicholas J. Wareham Nita G. Forouhi 0 ) MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of