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Endoscope-assisted resection of cavernous angioma at the foramen of Monro: a case report

Introduction Intraventricular cavernous angiomas are rare pathological entities, and those located at the foramen of Monro are even rarer. We herein present a case of cavernous angioma at the foramen of Monro that was successfully treated by neuroendoscope-assisted surgical removal, and review the relevant literature. Case presentation A 65-year-old woman had experienced headache...

Gene expression profiling of the anti-glioma effect of Cilengitide

Cilengitide (EMD121974), an inhibitor of the adhesive function of integrins, demonstrated preclinical efficacy against malignant glioma. It is speculated that cilengitide can inhibit tumor growth, invasion, and angiogenesis. However, the effects of cilengitide on these processes have not been sufficiently examined. In this study, we investigated the anti-glioma effect of...

Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy

Background The tumor microenvironment is being increasingly recognized as an important determinant of tumor progression as well as of therapeutic response. We investigated oncolytic virus (OV) therapy–induced changes in tumor blood vessels and the impact of modulating tumor vasculature on the efficacy of oncolytic virus therapy.

ANGIOGENESIS AND INVASION

INTRODUCTION: Recently, anti-angiogenic therapies have moved into the forefront of GBM targeted therapies, especially following the success of anti-VEGF treatment in increasing progression-free survival and quality of life for patients. However, with the recurrence of GBMs, anti-VEGF treatment seems insufficient at blocking glioma induced angiogenesis single-handedly. Sphingosine...

OMICS AND PROGNSTIC MARKERS

Joji Ishida , Kazuhiko Kurozumi, Tomotsugu Ichikawa, Manabu Onishi, Kentaro Fujii, Yosuke Shimazu, Tetsuo Oka , and Isao Date; Department of Neurological Surgery, Okayama University Graduate School of

LAB-EXPERIMENTAL (PRE-CLINICAL) THERAPEUTICS AND PHARMACOLOGY

CILENGITIDE TREATMENT FOR MALIGNANT GLIOMA Kazuhiko Kurozumi, Tomotsugu Ichikawa, Manabu Onishi, Kentaro Fujii, Joji Ishida, Yosuke Shimazu, and Isao Date; Okayama University Graduate School of Medicine

LAB–OMICS AND PROGNOSTIC MARKERS

MALIGNANT ASTROCYTIC GLIOMA Joji Ishida, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Manabu Onishi, Kentaro Fujii, Yosuke Shimazu, and Isao Date; Okayama University Graduate School of Medicine, Dentistry and