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Vocalizations during post-conflict affiliations from victims toward aggressors based on uncertainty in Japanese macaques

We investigated the use of vocalizations called “grunts,” “girneys,” and “coos” accompanied by post-conflict affiliative interaction between former opponents (reconciliation) in Japanese macaques (Macaca fuscata). Although reconciliation functions to repair bonds, such interactions sometimes entail risks of receiving further aggression. Vocalizations can be used at a distance...

New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases

The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1996 and 2015 in five hospitals by analyzing their baseline clinical features...

New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases

The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1996 and 2015 in five hospitals by analyzing their baseline clinical features...

New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases

The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1996 and 2015 in five hospitals by analyzing their baseline clinical features...

A pitfall of false lumen embolization in chronic aortic dissection: intimal injury caused by the embolization device edge

Naomichi Uchida 0 Yoshitaka Yamane 0 Kazunori Yamada 0 0 Department of Cardiovascular Surgery, Akane-Foundation Tsuchiya General Hospital , Hiroshima , Japan We report a case of intimal injury caused by the

Revisiting amino acid substitution matrices for identifying distantly related proteins

Kazunori Yamada 0 Kentaro Tomii 0 Associate Editor: Alfonso Valencia 0 0 Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST) , 2-4-7

Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease: a retrospective multicenter study

Ichiro Mizushima 0 Motohisa Yamamoto Dai Inoue Shinichi Nishi Yoshinori Taniguchi Yoshifumi Ubara Shoko Matsui Tetsuhiko Yasuno Hitoshi Nakashima Hiroki Takahashi Kazunori Yamada 0 Hideki Nomura Masakazu

Comparative Analysis of Seven Viral Nuclear Export Signals (NESs) Reveals the Crucial Role of Nuclear Export Mediated by the Third NES Consensus Sequence of Nucleoprotein (NP) in Influenza A Virus Replication

The assembly of influenza virus progeny virions requires machinery that exports viral genomic ribonucleoproteins from the cell nucleus. Currently, seven nuclear export signal (NES) consensus sequences have been identified in different viral proteins, including NS1, NS2, M1, and NP. The present study examined the roles of viral NES consensus sequences and their significance in...

A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein

Developing antiviral therapies for influenza A virus (IAV) infection is an ongoing process because of the rapid rate of antigenic mutation and the emergence of drug-resistant viruses. The ideal strategy is to develop drugs that target well-conserved, functionally restricted, and unique surface structures without affecting host cell function. We recently identified the antiviral...

PoSSuM v.2.0: data update and a new function for investigating ligand analogs and target proteins of small-molecule drugs

PoSSuM (http://possum.cbrc.jp/PoSSuM/) is a database for detecting similar small-molecule binding sites on proteins. Since its initial release in 2011, PoSSuM has grown to provide information related to 49 million pairs of similar binding sites discovered among 5.5 million known and putative binding sites. This enlargement of the database is expected to enhance opportunities for...

A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis

Background Bovine leukemia virus (BLV) is a member of retroviridae family, together with human T cell leukemia virus types 1 and 2 (HTLV-1 and -2) belonging to the genes deltaretrovirus, and infects cattle worldwide. Previous studies have classified the env sequences of BLV provirus from different geographic locations into eight genetic groups. To investigate the genetic...

Importin α3/Qip1 Is Involved in Multiplication of Mutant Influenza Virus with Alanine Mutation at Amino Acid 9 Independently of Nuclear Transport Function

The nucleoprotein (NP) of influenza A virus is transported into the nucleus via the classical importin α/β pathway, and proceeds via nuclear localization signals (NLSs) recognized by importin α molecules. Although NP binds to importin α isoforms Rch1, Qip1 and NPI-1, the role of each individual isoform during the nuclear transport of NP and replication of the influenza virus...

Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study

Ichiro Mizushima 0 Dai Inoue Motohisa Yamamoto Kazunori Yamada 0 Takako Saeki Yoshifumi Ubara Shoko Matsui Yasufumi Masaki Takashi Wada Satomi Kasashima Kenichi Harada Hiroki Takahashi Kenji Notohara

Clinical and histological changes associated with corticosteroid therapy in IgG4-related tubulointerstitial nephritis

Objectives This study aimed to investigate the clinicopathological changes induced by corticosteroid therapy in immunoglobulin (Ig)G4-related tubulointerstitial nephritis (TIN). Methods We studied six IgG4-related TIN patients receiving renal biopsies before and after corticosteroid therapy. Their clinical data and histological findings were evaluated before and after therapy...

Decreased Expression of Innate Immunity-Related Genes in Peripheral Blood Mononuclear Cells from Patients with IgG4-Related Disease

Background IgG4-related disease (IgG4-RD) is a new clinical entity of unknown etiology characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Although aberrancies in acquired immune system functions, including increases in Th2 and Treg cytokines observed in patients with IgG4-RD, its true etiology remains unclear. To investigate the...

Concurrent presentation of cryptococcal meningoencephalitis and systemic lupus erythematosus

Cryptococcal meningitis is a recognized complication of systemic lupus erythematosus (SLE), with high mortality rates, particularly in those treated with immunosuppressive agents. We describe a patient diagnosed simultaneously with cryptococcal meningoencephalitis and SLE and reviewed four similar cases reported in the literature. In our case, profound low CD4 lymphocyte count...

Unbalanced M1/M2 Phenotype of Peripheral Blood Monocytes in Obese Diabetic Patients: Effect of pioglitazone

patients, which may contribute to its antiatherogenic effect. NORIKO SATOH, MD, PHD1 AKIRA SHIMATSU, MD, PHD1 AKIHIRO HIMENO, MD1,2 YOUSUKE SASAKI, BSC1 HAJIME YAMAKAGE, BSC1 KAZUNORI YAMADA, MD, PHD2

Antiatherogenic Effect of Pioglitazone in Type 2 Diabetic Patients Irrespective of the Responsiveness to Its Antidiabetic Effect

NORIKO SATOH PHD YOSHIHIRO OGAWA PHD TAKESHI USUI PHD TETSUYA TAGAMI PHD SHIGEO KONO PHD HIROKO UESUGI PHD HIROYUKI SUGIYAMA PHD AKIRA SUGAWARA PHD KAZUNORI YAMADA PHD AKIRA SHIMATSU PHD HIDESHI