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44 papers found.
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The emerging role of fibrocytes in ocular disorders

The fibrocyte, which was first described in 1994, is a type of circulating mesenchymal progenitor cell in the peripheral blood. Fibrocytes play important roles in chronic inflammation, wound healing, tissue remodeling, and fibrosis. Emerging evidence indicates that fibrocytes are involved in a wide variety of ocular disorders associated with inflammation and fibrosis. In this...

Multiple enhancer regions govern the transcription of CCN2 during embryonic development

CCN2 is a critical matricellular protein that is expressed in several cells with major implications in physiology and different pathologies. However, the transcriptional regulation of this gene remains obscure. We used the Encyclopaedia of DNA Elements browser (ENCODE) to visualise the region spanning from 300 kb upstream to the CCN2 start site in silico in order to identify...

Online Active Learning with Drifted Data Streams Using Paired Ensemble Framework

In learning to classify data streams, it is impractical and expensive to label all of the instances. Online active learning over streaming data poses additional challenges for its increasing volumes and concept drifts. We propose a new online paired ensemble active learning framework consisting of a stable classifier and a timely substituted dynamic classifier to react to...

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons

: Jacqueline S. de Belleroche. Formal analysis: Nazanin Rahmani Kondori, Praveen Paul, Jacqueline P. Robbins, Ke Liu, John C. W. Hildyard, Dominic J. Wells, Jacqueline S. de Belleroche. Funding acquisition ... : Dominic J. Wells, Jacqueline S. de Belleroche. Investigation: Nazanin Rahmani Kondori, Praveen Paul, Jacqueline P. Robbins, Ke Liu, John C. W. Hildyard, Dominic J. Wells, Jacqueline S. de Belleroche. 19

Effects of Zn, macronutrients, and their interactions through foliar applications on winter wheat grain nutritional quality

Wang, Meng Li. Formal analysis: Shaoxia Wang, Meng Li, Ke Liu, Shuo Li, Yanlong Chen, Zhou Jia. Funding acquisition: Xiaohong Tian. Investigation: Shaoxia Wang, Meng Li, Xiaohong Tian. Methodology ... : Shaoxia Wang, Meng Li, Ke Liu, Xiaohong Tian. Project administration: Xiaohong Tian. Resources: Shaoxia Wang, Meng Li, Shuo Li, Yanlong Chen. Software: Shaoxia Wang, Meng Li, Ke Liu, Shuo Li

RNAMethPre: A Web Server for the Prediction and Query of mRNA m6A Sites

N6-Methyladenosine (m6A) is the most common mRNA modification; it occurs in a wide range of taxon and is associated with many key biological processes. High-throughput experiments have identified m6A-peaks and sites across the transcriptome, but studies of m6A sites at the transcriptome-wide scale are limited to a few species and tissue types. Therefore, the computational...

Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism

S.L. Friedman, Mount Sinai School of Medicine, NY, for his generous gift of LX2 Author Contributions Data curation: Jiang Li, Ke Liu. Conceptualization: Jiang Li, Yixian Huang, Jie Fan, Fengtian He ... Li, Mohammed Ghazwani, Ke Liu, Na Chang. Project administration: Jiang Li. Resources: Jiang Li, Na Chang, Jie Fan. Supervision: Liying Li, Shizhong Bu, Wen Xie, Xiaochao Ma, Song Li. Validation

Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population

Wen conducted the sample collection and verification. Qingli Guo and Zhijian Song undertook the statistical analysis. Ke Liu and Zhaowei Zhou were responsible for platform coordination and management

Cross-Species Extrapolation of Models for Predicting Lead Transfer from Soil to Wheat Grain

The transfer of Pb from the soil to crops is a serious food hygiene security problem in China because of industrial, agricultural, and historical contamination. In this study, the characteristics of exogenous Pb transfer from 17 Chinese soils to a popular wheat variety (Xiaoyan 22) were investigated. In addition, bioaccumulation prediction models of Pb in grain were obtained...

Effect of Straw Amendment on Soil Zn Availability and Ageing of Exogenous Water-Soluble Zn Applied to Calcareous Soil

Organic matter plays a key role in availability and transformation of soil Zn (zinc), which greatly controls Zn concentrations in cereal grains and human Zn nutrition level. Accordingly, soils homogenized with the wheat straw (0, 12 g straw kg-1) and Zn fertilizer (0, 7 mg Zn kg-1) were buried and incubated in the field over 210 days to explore the response of soil Zn...

Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity

Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme family in mice results in important joint and bone abnormalities, suggesting a role in skeletal development. As such, the control of MMP activity is vital in the complex process of bone formation and growth...

Improved osteogenesis and upregulated immunogenicity in human placenta-derived mesenchymal stem cells primed with osteogenic induction medium

Background Mesenchymal stem cells (MSCs) are widely used in cell-based therapy owing to their multilineage potential and low immunogenicity. However, low differentiation efficiency and unpredictable immunogenicity of allogeneic MSCs in vivo limit their success in therapeutic treatment. Herein, we evaluated the differentiation potential and immunogenicity of human placenta-derived...

A regularization-free elasticity reconstruction method for ultrasound elastography with freehand scan

Background In ultrasound elastography, reconstruction of tissue elasticity (e.g., Young’s modulus) requires regularization and known information of forces and/or displacements on tissue boundaries. In practice, it is challenging to choose an appropriate regularization parameter; and the boundary conditions are difficult to obtain in vivo. The purpose of this study is to develop a...

Identification and characterization of a novel stress-responsive outer membrane protein Lip40 from Actinobacillus pleuropneumoniae

Background Actinobacillus pleuropneumoniae, a Gram-negative bacterium, is the causative agent of porcine pleuropneumonia, a highly contagious and often fatal disease. Because current vaccines confer limited protection against A. pleuropneumoniae infection, the development of more effective vaccines is urgently required. The identification of immunogenic and protective antigens...

MeSHLabeler: improving the accuracy of large-scale MeSH indexing by integrating diverse evidence

Motivation: Medical Subject Headings (MeSHs) are used by National Library of Medicine (NLM) to index almost all citations in MEDLINE, which greatly facilitates the applications of biomedical information retrieval and text mining. To reduce the time and financial cost of manual annotation, NLM has developed a software package, Medical Text Indexer (MTI), for assisting MeSH...

Cloning and characterization of the pepper CaPAO gene for defense responses to salt-induced leaf senescence

Background Pheophorbide a oxygenase (PAO) is an important enzyme in the chlorophyll catabolism pathway and is involved in leaf senescence. It opens the porphyrin macrocycle of pheophorbide a and finally forms the primary fluorescent chlorophyll catabolite. Previous studies have demonstrated the function of PAO during cell death. However, the characterizaton of PAO during leaf...

Porcine Mx1 fused to HIV Tat protein transduction domain (PTD) inhibits classical swine fever virus infection in vitro and in vivo

Background Classical swine fever (CSF) caused by CSF virus (CSFV) is highly contagious andcauses significant economic losses in the pig industry throughout the world. Previously we demonstrated that porcine Mx1 (poMx1), when fused to HIV Tat protein transduction domain (PTD), inhibits CSFV propagation in PK-15 cells, but it is unknown whether PTD-poMx1 exhibits antiviral activity...

The sensitivity and significance analysis of parameters in the model of pH regulation on lactic acid production by Lactobacillus bulgaricus

Background The excessive production of lactic acid by L. bulgaricus during yogurt storage is a phenomenon we are always tried to prevent. The methods used in industry either control the post-acidification inefficiently or kill the probiotics in yogurt. Genetic methods of changing the activity of one enzyme related to lactic acid metabolism make the bacteria short of energy to...

Linc2GO: a human LincRNA function annotation resource based on ceRNA hypothesis

Summary: Large numbers of long intergenic non-coding RNA (lincRNA) have been detected through high-throughput sequencing technology. However, currently we still know very little about their functions. Therefore, a lincRNA function annotation database is needed to facilitate the study in this field. In this article, we present Linc2GO, a web resource that aims to provide...