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Lipocalin 2: a potential therapeutic target for breast cancer metastasis

Lipocalin 2: a potential therapeutic target for breast cancer metastasis Chenxia Hu,1 Ke Yang,1 Mengjie Li,1 Weiping Huang,2 Fengxue Zhang,2 Hongqi Wang2 1School of Pharmaceutical Science, Guangzhou

Nano-copper-bearing stainless steel promotes fracture healing by accelerating the callus evolution process

Jiang,3 Kerong Dai,1 Ke Yang,2 Yongqiang Hao1 1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of

Aromatic amino acids in the cellulose binding domain of Penicillium crustosum endoglucanase EGL1 differentially contribute to the cellulose affinity of the enzyme

The cellulose binding domain (CBD) of cellulase binding to cellulosic materials is the initiation of a synergistic action on the enzymatic hydrolysis of the most abundant renewable biomass resources in nature. The binding of the CBD domain to cellulosic substrates generally relies on the interaction between the aromatic amino acids structurally located on the flat face of the CBD...

Prognostic value of plasma EGFR ctDNA in NSCLC patients treated with EGFR-TKIs

Objective Epidermal growth factor receptor (EGFR) specific mutations have been known to improve survival of patients with non-small-cell lung carcinoma (NSCLC). However, whether there are any changes of EGFR mutations after targeted therapy and its clinical significance is unclear. This study was to identify the status of EGFR mutations after targeted therapy and predict the...

Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle

Chongqing Medical University, Chongqing 400014, China Correspondence should be addressed to Ke Yang; moc.361@41101287 Received 5 July 2016; Revised 4 January 2017; Accepted 24 January 2017; Published 27 ... Foundation of China (no. 81301350) and Basic and Advanced Research Projects in Chongqing (no. cstc2013jcyjA10021). Ke Yang was supported by the National Natural Science Foundation of China (no. 81371718

Association of long noncoding RNAs expression levels and their gene polymorphisms with systemic lupus erythematosus

, Anhui Medical University, Anhui, P. R. ChinaJun Li, Guo-Cui Wu, Tian-Ping Zhang, Xiao-Ke Yang, Shuang-Shuang Chen, Lian-Ju Li, Shu-Zhen Xu, Tian-Tian Lv, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing YeAnhui ... Province Key Laboratory of Major Autoimmune Diseases, Anhui, P. R. ChinaJun Li, Guo-Cui Wu, Tian-Ping Zhang, Xiao-Ke Yang, Shuang-Shuang Chen, Lian-Ju Li, Shu-Zhen Xu, Tian-Tian Lv, Rui-Xue Leng, Hai-Feng

Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway

Background Wogonin is an encouraging choice for clinical use owing to its potent anti-tumor and anti-inflammatory effects with the high safety profile. However, wogonin for targeted therapy of lymphoma was not well addressed. In this study, we focused on its anticancer effect alongside with the underlying mechanisms for targeted therapy in EBV-positive lymphoma. This will...

Backbone cup – a structure design competition based on topology optimization and 3D printing

This paper addresses a structure design competition based on topology optimization and 3D Printing, and proposes an experimental approach to efficiently and quickly measure the mechanical performance of the structures designed using topology optimization. Since the topology optimized structure designs are prone to be geometrically complex, it is extremely inconvenient to...

Backbone cup – a structure design competition based on topology optimization and 3D printing

This paper addresses a structure design competition based on topology optimization and 3D Printing, and proposes an experimental approach to efficiently and quickly measure the mechanical performance of the structures designed using topology optimization. Since the topology optimized structure designs are prone to be geometrically complex, it is extremely inconvenient to...

Dramatically Enhanced Visible Light Response of Monolayer ZrS2 via Non-covalent Modification by Double-Ring Tubular B20 Cluster

The ability to strongly absorb light is central to solar energy conversion. We demonstrate here that the hybrid of monolayer ZrS2 and double-ring tubular B20 cluster exhibits dramatically enhanced light absorption in the entire visible spectrum. The unique near-gap electronic structure and large built-in potential at the interface will lead to the robust separation of...

Flexoelectric effect in an in-plane switching (IPS) liquid crystal cell for low-power consumption display devices

ScholarSearch for Dong-Woo Kim in:Nature Research journals • PubMed • Google ScholarSearch for Deng-Ke Yang in:Nature Research journals • PubMed • Google ScholarSearch for Joong Hee Lee in:Nature Research

Black hole solution and strong gravitational lensing in Eddington-inspired Born–Infeld gravity

A new theory of gravity called Eddington-inspired Born–Infeld (EiBI) gravity was recently proposed by Bañados and Ferreira. This theory leads to some exciting new features, such as free of cosmological singularities. In this paper, we first obtain a charged EiBI black hole solution with a nonvanishing cosmological constant when the electromagnetic field is included in. Then based...

Brane worlds in gravity with auxiliary fields

Recently, Pani et al. explored a new theory of gravity by adding nondynamical fields, i.e., gravity with auxiliary fields (Phys Rev D 88:121502, 2013). In this gravity theory, higher-order derivatives of matter fields generically appear in the field equations. In this paper we extend this theory to any dimensions and discuss the thick braneworld model in five dimensions. Domain...

Association between a vascular endothelial growth factor gene polymorphism (rs2146323) and diabetic retinopathy: a meta-analysis

manuscript declare no conflict of interest and have no financial relationship with organizations. Authors’ contributions Conceived and designed the study: Ying Zeng, Ke Yang, and Yongqing Tang; Acquisition of ... data: Fangjie Dai, Meng Xu, and Yiwu Zhou; Analysis and interpretation of data: Ying Zeng and Ke Yang; Drafting the manuscript: Ying Zeng and Fangjie Dai; Revising the manuscript critically for important

A novel nano-copper-bearing stainless steel with reduced Cu2+ release only inducing transient foreign body reaction via affecting the activity of NF-κB and Caspase 3

,* Tingting Tang,1 Kerong Dai,1 Ke Yang,2 Yongqiang Hao1 1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of

An investigation of the antibacterial ability and cytotoxicity of a novel cu-bearing 317L stainless steel

• PubMed • Google ScholarSearch for Tingyue Gu in:Nature Research journals • PubMed • Google ScholarSearch for Ke Yang in:Nature Research journals • PubMed • Google ScholarSearch for Guixue Wang in:Nature ... interests The authors declare no competing financial interests. Corresponding authors Correspondence to Ke Yang or Guixue Wang. Rights and permissions This work is licensed under a Creative Commons

Recombinant Escherichia coli Strains with Inducible Campylobacter jejuni Single Domain Hemoglobin CHb Expression Exhibited Improved Cell Growth in Bioreactor Culture

Maintaining an appropriate concentration of dissolved oxygen in aqueous solution is critical for efficient operation of a bioreactor, requiring sophisticated engineering design and a system of regulation to maximize oxygen transfer from the injected air bubbles to the cells. Bacterial hemoglobins are oxygen-binding proteins that transfer oxygen from the environment to metabolic...

Experimental investigation into stress-relief characteristics with upward large height and upward mining under hard thick roof

According to geological conditions of No. 3 and No. 4 coal seams (namely A3 and B4) of the Pan’er coal mine and the parameters of panels 11223, 11224, and 11124 with fully-mechanical coal mining, we built 2D similar material simulation and FLAC3D numerical simulation models to investigate the development of mining-induced stress and the extraction effect of pressure-relief gas...