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Collagen Damage Location in Articular Cartilage Differs if Damage is Caused by Excessive Loading Magnitude or Rate

Collagen damage in articular cartilage is considered nearly irreversible and may be an early indication of cartilage degeneration. Surface fibrillation and internal collagen damage may both develop after overloading. This study hypothesizes that damage develops at these different locations, because the distribution of excessive strains varies with loading rate as a consequence of...

Link-N: The missing link towards intervertebral disc repair is species-specific

was generously provided by TETEC AG. Author Contributions Conceptualization: Frances C. Bach, Laura B. Creemers, Keita Ito, BjoÈrn P. Meij, Fackson Mwale. Data curation: Frances C. Bach, Michael P ... . Grant. Formal analysis: Frances C. Bach. Funding acquisition: Laura B. Creemers, Keita Ito, BjoÈrn P. Meij, Fackson Mwale, Marianna A. Tryfonidou. Investigation: Frances C. Bach, Lisanne T. Laagland

Increased caveolin-1 in intervertebral disc degeneration facilitates repair

Background Preceding intervertebral disc (IVD) degeneration, the cell phenotype in the nucleus pulposus (NP) shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs). Microarray analysis showed a correlation between caveolin-1 expression and the phenotypic transition of NCs to CLCs. With a clinical directive in mind, the aim of this study was to determine the role of...

A Well-Controlled Nucleus Pulposus Tissue Culture System with Injection Port for Evaluating Regenerative Therapies

In vitro evaluation of nucleus pulposus (NP) tissue regeneration would be useful, but current systems for NP culture are not ideal for injections. The aim of this study was to develop a long-term culture system for NP tissue that allows injections of regenerative agents. Bovine caudal NPs were harvested and placed in the newly designed culture system. After equilibration of the...

Reviewer’s comments concerning “Biomechanical evaluation of segmental instability in degenerative lumbar spondylolisthesis” by K. Hasegawa et al. (ESJO-D-08-00441R1)

Keita Ito 0 0 K. Ito (&) Department of Biomedical Engineering, Eindhoven University of Technology , Postbox 513, WH3.116, 5600 MB Eindhoven, The Netherlands - In this study, a controlled cyclic

Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration

Introduction Early degenerative changes in the nucleus pulposus (NP) are observed after the disappearance of notochordal cells (NCs). Thus, it has been suggested that NCs play an important role in maintaining the NP and may have a regenerative potential on other cells of the NP. As the number of resident NP cells (NPCs) decreases in a degenerating disc, mesenchymal stromal (stem...

The effect of tissue-engineered cartilage biomechanical and biochemical properties on its post-implantation mechanical behavior

Mehdi Khoshgoftar Wouter Wilson Keita Ito Corrinus C. van Donkelaar The insufficient load-bearing capacity of today's tissue-engineered (TE) cartilage limits its clinical application. Focus has

Potential regenerative treatment strategies for intervertebral disc degeneration in dogs

Pain due to spontaneous intervertebral disc (IVD) disease is common in dogs. In chondrodystrophic (CD) dogs, IVD disease typically develops in the cervical or thoracolumbar spine at about 3–7 years of age, whereas in non-chondrodystrophic (NCD) dogs, it usually develops in the caudal cervical or lumbosacral spine at about 6–8 years of age. IVD degeneration is characterized by...

Tissue engineering of functional articular cartilage: the current status

Linda Kock Corrinus C. van Donkelaar Keita Ito 0 ) Department of Biomedical Engineering, Eindhoven University of Technology , Eindhoven, Netherlands Osteoarthritis is a degenerative joint disease

World Forum for Spine Research: The intervertebral disc

Low back pain and intervertebral disc degeneration are the most common reasons for sick leave from work and disability worldwide. To date, the reasons for intervertebral disc degeneration and the cause of back pain remain unsolved, while biological approaches to prevent back pain or reverse disc degeneration are showing promising progress.The concept of a “World Forum” began with...

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Bone adapts its morphology (density/micro- architecture) in response to the local loading conditions in such a way that a uniform tissue loading is achieved (‘Wolff’s law’). This paradigm has been used as a basis for bone remodeling simulations to predict the formation and adaptation of trabecular bone. However, in order to predict bone architectural changes in patients, the...

Influencing biophysical properties of fibrin with buffer solutions

Fibrin has been proposed as cell scaffold for numerous tissue engineering applications. While most of the studies have focused on fibrinogen and thrombin, other components of fibrin can also affect its properties. The present study aimed to evaluate the effects of buffer solution composition on fibrin biophysical properties. Fibrin scaffolds were synthesized with different...

The Effect of Dexamethasone and Triiodothyronine on Terminal Differentiation of Primary Bovine Chondrocytes and Chondrogenically Differentiated Mesenchymal Stem Cells

The newly evolved field of regenerative medicine is offering solutions in the treatment of bone or cartilage loss and deficiency. Mesenchymal stem cells, as well as articular chondrocytes, are potential cells for the generation of bone or cartilage. The natural mechanism of bone formation is that of endochondral ossification, regulated, among other factors, through the hormones...

A sclerostin-based theory for strain-induced bone formation

Ren F. M. van Oers Bert van Rietbergen Keita Ito Peter A. J. Hilbers Rik Huiskes Bone formation responds to mechanical loading, which is believed to be mediated by osteocytes. Previous theories