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Search: authors:"Keith M. Gligorich"

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Automated size selection for short cell-free DNA fragments enriches for circulating tumor DNA and improves error correction during next generation sequencing

. Data curation: Sabine Hellwig, David A. Nix, Keith M. Gligorich, Alun Thomas, Carrie L. Fuertes, Preetida J. Bhetariya, Hunter R. Underhill. Formal analysis: Sabine Hellwig, David A. Nix, Hunter R ... . Underhill. Funding acquisition: Mary P. Bronner, Hunter R. Underhill. Investigation: Sabine Hellwig, Hunter R. Underhill. Methodology: Sabine Hellwig, Keith M. Gligorich, John M. O'Shea, Alun Thomas, Mary

The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress

Introduction The establishment of drug resistance following treatment with chemotherapeutics is strongly associated with poor clinical outcome in patients, and drugs that target chemoresistant tumors have the potential to increase patient survival. In an effort to identify biological pathways of chemoresistant breast cancers that can be targeted therapeutically, a small molecule...

Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells

Introduction High failure rates of new investigational drugs have impaired the development of breast cancer therapies. One challenge is that excellent activity in preclinical models, such as established cancer cell lines, does not always translate into improved clinical outcomes for patients. New preclinical models, which better replicate clinically-relevant attributes of cancer...

Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant

Defining master transcription factors governing somatic and cancer stem cell identity is an important goal. Here we show that the Oct4 paralog Oct1, a transcription factor implicated in stress responses, metabolic control, and poised transcription states, regulates normal and pathologic stem cell function. Oct1HI cells in the colon and small intestine co-express known stem cell...