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Sex-specific reference intervals of hematologic and biochemical analytes in Sprague-Dawley rats using the nonparametric rank percentile method

Conceptualization: Keliang Liu. Data curation: Qili He. Formal analysis: Qili He, Guoming Su. Funding acquisition: Keliang Liu. Investigation: Fangcheng Zhang, Yong Jiang, Jun Gao, Lida Liu, Zhongren Jiang, Minwu ... Jin, Huiping Xie. Methodology: Guoming Su, Fangcheng Zhang, Minwu Jin. Resources: Keliang Liu, Jun Gao, Zhongren Jiang, Huiping Xie. Software: Qili He, Guoming Su. Supervision: Keliang Liu

A Drug Carrier for Sustained Zero-Order Release of Peptide Therapeutics

Jiankun Qie Keliang Liu Yongjun Zhang Peptides have great potential as therapeutic agents, however, their clinic applications are severely hampered by their instability and short circulation half-life ... purified and characterized the peptide. Ya-Nan Zhao, Rui Song, Danni Cao, Siqi Cheng and Yansheng Dong performed the animal experiments. Yongjun Zhang, Qingbin Meng, Ying Guan and Keliang Liu analyzed the

In Vitro Metabolic Stability of Exendin-4: Pharmacokinetics and Identification of Cleavage Products

The aim of this study was to investigate the metabolic stability and cleavage sites of exendin-4 in rat tissue homogenates, as well as to identify the types of proteases involved in exendin-4 degradation. The stability of exendin-4 in kidney and liver homogenates from rats was evaluated using liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) with...

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

in:Nature Research journals • PubMed • Google ScholarSearch for Lanying Du in:Nature Research journals • PubMed • Google ScholarSearch for Keliang Liu in:Nature Research journals • PubMed • Google

NMR structure of a parallel-stranded DNA duplex at atomic resolution

DNA dodecamers have been designed with two cytosines on each end and intervening A and T stretches, such that the oligomers have fully complementary A:T base pairs when aligned in the parallel orientation. Spectroscopic (UV, CD and IR), NMR and molecular dynamics studies have shown that oligomers having the sequences d(CCATAATTTACC) and d(CCTATTAAATCC) form a parallel-stranded...

A novel palindromic triple-stranded structure formed by homopyrimidine dodecamer d-CTTCTCCTCTTC and homopurine hexamer d-GAAGAG

, Bethesda 1 Department of Chemical Sciences, Tata Institute of Fundamental Research , Homi Bhabha Road, Mumbai 400 005, India 2 Permanent address: Keliang Liu, Institute of Pharmacology and Toxicology , PO