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NMR structure of a parallel-stranded DNA duplex at atomic resolution

DNA dodecamers have been designed with two cytosines on each end and intervening A and T stretches, such that the oligomers have fully complementary A:T base pairs when aligned in the parallel orientation. Spectroscopic (UV, CD and IR), NMR and molecular dynamics studies have shown that oligomers having the sequences d(CCATAATTTACC) and d(CCTATTAAATCC) form a parallel-stranded...

A novel palindromic triple-stranded structure formed by homopyrimidine dodecamer d-CTTCTCCTCTTC and homopurine hexamer d-GAAGAG

, Bethesda 1 Department of Chemical Sciences, Tata Institute of Fundamental Research , Homi Bhabha Road, Mumbai 400 005, India 2 Permanent address: Keliang Liu, Institute of Pharmacology and Toxicology , PO

Sex-specific reference intervals of hematologic and biochemical analytes in Sprague-Dawley rats using the nonparametric rank percentile method

Conceptualization: Keliang Liu. Data curation: Qili He. Formal analysis: Qili He, Guoming Su. Funding acquisition: Keliang Liu. Investigation: Fangcheng Zhang, Yong Jiang, Jun Gao, Lida Liu, Zhongren Jiang, Minwu ... Jin, Huiping Xie. Methodology: Guoming Su, Fangcheng Zhang, Minwu Jin. Resources: Keliang Liu, Jun Gao, Zhongren Jiang, Huiping Xie. Software: Qili He, Guoming Su. Supervision: Keliang Liu

In Vitro Metabolic Stability of Exendin-4: Pharmacokinetics and Identification of Cleavage Products

The aim of this study was to investigate the metabolic stability and cleavage sites of exendin-4 in rat tissue homogenates, as well as to identify the types of proteases involved in exendin-4 degradation. The stability of exendin-4 in kidney and liver homogenates from rats was evaluated using liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) with...

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

in:Nature Research journals • PubMed • Google ScholarSearch for Lanying Du in:Nature Research journals • PubMed • Google ScholarSearch for Keliang Liu in:Nature Research journals • PubMed • Google