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16 papers found.
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Cancer immunotherapies targeting the PD-1 signaling pathway

Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have ...

Cancer immunotherapies targeting the PD-1 signaling pathway

Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have ...

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors

Invariant natural killer T (iNKT) cells recognize self-lipids presented by CD1d through characteristic TCRs, which mainly consist of the invariant Vα14-Jα18 TCRα chain and Vβ8.2, 7 or 2 TCRβ chains with hypervariable CDR3β sequences in mice. The iNKT cell-CD1d axis is conserved between humans and mice, and human CD1d reactivity of murine iNKT cells have been described. However, the ...

Detection of murine post-pneumonectomy lung regeneration by 18FDG PET imaging

EJNMMI Research Detection of murine post-pneumonectomy lung 18 regeneration by FDG PET imaging Barry C Gibney 0 Mi-Ae Park Kenji Chamoto 0 Alexandra Ysasi 0 Moritz A Konerding Akira Tsuda Steven J

A Th17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-γ production in order to induce airway hyperresponsiveness

Adoptive cell transfer of an ovalbumin (OVA)-specific Th17-polarized cell population from transgenic DO11.10 mice into BALB/c mice followed by OVA inhalation caused airway hyperresponsiveness (AHR) with severe neutrophilia. The transferred Th17 cell population—previously polarized in vitro with IL-6, transforming growth factor-β and IL-23—contained negligible numbers of ...

Angiogenesis gene expression in murine endothelial cells during post-pneumonectomy lung growth

Although blood vessel growth occurs readily in the systemic bronchial circulation, angiogenesis in the pulmonary circulation is rare. Compensatory lung growth after pneumonectomy is an experimental model with presumed alveolar capillary angiogenesis. To investigate the genes participating in murine neoalveolarization, we studied the expression of angiogenesis genes in lung ...

A novel tumor‐vaccine cell therapy using bone marrow‐derived dendritic cell type 1 and antigen‐specific Th1 cells

Marimo Sato 0 Kenji Chamoto 0 Takashi Nishimura 0 0 Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University , Kita-15, Nishi-7, Kita-Ku, Sapporo 060-0815, Japan Dendritic

CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung

Allergic airway inflammation is one of the most typical characteristic features of bronchial asthma. Th2 cells, which produce IL-4, IL-5 and IL-13, are well known as major effector lymphocytes of the inflammation. In the present work, we found that subcutaneous injection of Toll-like receptor-9-ligand, CpG-oligodeoxynucleotides (CpG-ODN), remarkably suppressed eosinophilia and ...

Th1 cell adjuvant therapy combined with tumor vaccination: a novel strategy for promoting CTL responses while avoiding the accumulation of Tregs

We have previously described a method for adoptive immunotherapy of cancer based on antigen-specific Th1 cells. However, efficient induction of anti-tumor responses using Th1 cells remains a formidable challenge, especially for MHC class II-negative tumors. In the present study, we sought to develop a novel strategy to eradicate established tumors of the MHC class II-negative, ...

IFN-γ-dependent type 1 immunity is crucial for immunosurveillance against squamous cell carcinoma in a novel mouse carcinogenesis model

3-Methylcholanthrene (MCA)-induced sarcomas have been used as conventional tools for investigating immunosurveillance against tumor development. However, MCA-induced sarcoma is not always an ideal model for the study of the human cancer system because carcinomas and not sarcomas are the dominant types of human cancers. To resolve this problem, we established a novel and simple ...

Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a Th17-independent manner

Naive CD4+ T cells rapidly proliferate to generate effector cells after encountering an antigen and small numbers survive as memory T cells in preparation for future immunological events. In the present work, adoptive transfer of naive CD4+ T cells into RAG2−/− mice caused the generation of memory-type effector T cells including Th1, Th2, Th17 and regulatory T cells, and eventually ...

An indispensable role of type-1 IFNs for inducing CTL-mediated complete eradication of established tumor tissue by CpG-liposome co-encapsulated with model tumor antigen

We have evaluated the capacity of a novel, nanoparticle-based tumor vaccine to eradicate established tumors in mice. C57BL/6 mice were intradermally (i.d.) inoculated with ovalbumin (OVA)-expressing EG-7 tumor cells. When the tumor size reached 7–8 mm, the tumor-bearing mice were i.d. injected near the tumor-draining lymph node (DLN) with liposomes encapsulated with unmethylated ...

Differential regulation of VLA‐2 expression on Th1 and Th2 cells: a novel marker for the classification of Th subsets

We found that Th1 cells derived from ovalbumin (OVA)‐specific TCR transgenic (DO11.10) mice showed significantly higher levels of VLA‐2 (CD49b/CD29) expression than Th2 cells. In the early days (until 6 days) during induction of Th1 or Th2 cells, the expression of VLA‐2 was gradually increased on both Th subsets. Thereafter, VLA‐2 expression was further up‐regulated on Th1 cells ...

Unexpected role of TNF‐α in graft versus host reaction (GVHR): donor‐derived TNF‐α suppresses GVHR via inhibition of IFN‐γ‐dependent donor type‐1 immunity

Graft versus host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation, leading to significant morbidity and mortality. Host‐derived TNF‐α play a role in the induction of allo‐reactive donor T cell activation and the pathogenesis of GVHD. On the other hand, the precise role of donor‐derived TNF‐α in GVHD remains unclear. To elucidate this ...

STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation

When wild-type BALB/c mice were transferred with OVA-specific Th2 cells followed by OVA inhalation, a severe eosinophilia, mucus hypersecretion and airway hyper-responsiveness (AHR) was induced in parallel with a marked elevation of IL-4, IL-5 and IL-13 levels in bronchoalveolar lavage fluid (BALF). However, neither eosinophilia, AHR nor mucus hypersecretion was induced in Th2 ...