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Effects of glucose, insulin, and insulin resistance on cerebral 18F-FDG distribution in cognitively normal older subjects

Gerontology for their technical assistance. Author Contributions Conceptualization: Kenji Ishibashi, Yoshinori Fujiwara, Kenji Ishii. Data curation: Kenji Ishibashi, Airin Onishi, Yoshinori Fujiwara, Kiichi ... Ishiwata, Kenji Ishii. Formal analysis: Kenji Ishibashi, Airin Onishi. Funding acquisition: Kenji Ishibashi. Investigation: Kenji Ishibashi, Airin Onishi, Yoshinori Fujiwara, Kiichi Ishiwata, Kenji Ishii

Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers

Background N,N-di-n-propyl-2-[2-(4-[11C]methoxyphenyl)-6,8-dichloroimidazol[1,2-a]pyridine-3-yl]acetamide ([11C]CB184) is a novel selective radioligand for the 18-kD translocator protein (TSPO), which is upregulated in activated microglia in the brain, and may be useful in positron emission tomography (PET). We examined the safety, radiation dosimetry, and initial brain imaging...

Individual time course of pre- and postsynaptic PET imaging may improve differential diagnosis of Parkinson’s disease and multiple system atrophy: a case report

Background Many in vivo studies have shown a difference in pre- and/or postsynaptic imaging between Parkinson’s disease and multiple system atrophy; however, time course differences in pre- and postsynaptic imaging between Parkinson’s disease and multiple system atrophy have not been rigorously investigated. Case presentation We report serial positron emission tomography images...

Test-retest variability of adenosine A2A binding in the human brain with 11C-TMSX and PET

Background The goal of the present study was to evaluate the reproducibility of cerebral adenosine A2A receptor (A2AR) quantification using 11C-TMSX and PET in a test-retest study. Methods Five healthy volunteers were studied twice. The test-retest variability was assessed for distribution volume (VT) and binding potential relative to non-displaceable uptake (BPND) based on...

Neural Substrates for Semantic Memory of Familiar Songs: Is There an Interface between Lyrics and Melodies?

Findings on song perception and song production have increasingly suggested that common but partially distinct neural networks exist for processing lyrics and melody. However, the neural substrates of song recognition remain to be investigated. The purpose of this study was to examine the neural substrates involved in the accessing “song lexicon” as corresponding to a...

Binding of Pramipexole to Extrastriatal Dopamine D2/D3 Receptors in the Human Brain: A Positron Emission Tomography Study Using 11C-FLB 457

The purpose of this study was to determine the binding sites of pramipexole in extrastriatal dopaminergic regions because its antidepressive effects have been speculated to occur by activating the dopamine D2 receptor subfamily in extrastriatal areas. Dynamic positron emission tomography (PET) scanning using 11C-FLB 457 for quantification of D2/D3 receptor subtype was performed...

Imaging spectrum of sporadic cerebral amyloid angiopathy: multifaceted features of a single pathological condition

Objectives Sporadic cerebral amyloid angiopathy (CAA) is common cause of cerebrovascular disorders that predominantly affect elderly patients. When symptomatic, cortical-subcortical intracerebral haemorrhage (ICH) in the elderly is the most well-known manifestation of CAA. Furthermore, the clinical presentation varies from a sudden neurological deficit to seizures, transient...

Contributions of biological tumor parameters to the incorporation rate of l-[methyl-11C] methionine into astrocytomas and oligodendrogliomas

We compared the tumor uptake of 11C-methionine (MET) with positron emission tomography (PET) with the results of a pathological analysis to examine the proliferative potential and microvessel density measured with immunostaining for MIB-1 and factor VIII, respectively, from 33 patients with glioma. The MET uptake in oligodendrogliomas was significantly greater than that in grade...

Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients

Adenosine A2A receptors (A2ARs) are thought to interact negatively with the dopamine D2 receptor (D2R), so selective A2AR antagonists have attracted attention as novel treatments for Parkinson's disease (PD). However, no information about the receptor in living patients with PD is available. The purpose of this study was to investigate the relationship between A2ARs and the...

Conjoint and Extended Neural Networks for the Computation of Speech Codes: The Neural Basis of Selective Impairment in Reading Words and Pseudowords

., 1990; Lukatela and Turvey, 1993; Stone and Van Orden, 1993). A common explanation for Benjamin Xu, Jordan Grafman1, William D. Gaillard2, Kenji Ishii, Francisco Vega-Bermudez, Pietro Pietrini1