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Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers

Background N,N-di-n-propyl-2-[2-(4-[11C]methoxyphenyl)-6,8-dichloroimidazol[1,2-a]pyridine-3-yl]acetamide ([11C]CB184) is a novel selective radioligand for the 18-kD translocator protein (TSPO), which is upregulated in activated microglia in the brain, and may be useful in positron emission tomography (PET). We examined the safety, radiation dosimetry, and initial brain imaging...

Study on an Undershot Cross-Flow Water Turbine with Straight Blades

Small-scale hydroelectric power generation has recently attracted considerable attention. The authors previously proposed an undershot cross-flow water turbine with a very low head suitable for application to open channels. The water turbine was of a cross-flow type and could be used in open channels with the undershot method, remarkably simplifying its design by eliminating...

Evaluation of [11C]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis

Kentaro Hatano 1 Rudi A. J. O. Dierckx 1 Janine Doorduin 1 0 ) Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen , PO Box 30.001, 9700 RB

Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [11C](R)-PK11195

Objective We report synthesis of two carbon-11 labeled imidazopyridines TSPO ligands, [11C]CB184 and [11C]CB190, for PET imaging of inflammatory process along with neurodegeneration, ischemia or brain tumor. Biodistribution of these compounds was compared with that of [11C]CB148 and [11C](R)-PK11195. Methods Both [11C]CB184 and [11C]CB190 having 11C-methoxyl group on an aromatic...