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Search: authors:"Keun-Young Kim"

4 papers found.
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DP2: Distributed 3D image segmentation using micro-labor workforce

Summary: This application note describes a new scalable semi-automatic approach, the Dual Point Decision Process, for segmentation of 3D structures contained in 3D microscopy. The segmentation problem is distributed to many individual workers such that each receives only simple questions regarding whether two points in an image are placed on the same object. A large pool of micro...

Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury

protein expression in ischemic retina. In addition, the CoQ10 significantly blocked activation of astroglial and Dongwook Lee and Keun-Young Kim have contributed equally to this work. - Elevated

Potential Energy Landscape and Robustness of a Gene Regulatory Network: Toggle Switch

Finding a multidimensional potential landscape is the key for addressing important global issues, such as the robustness of cellular networks. We have uncovered the underlying potential energy landscape of a simple gene regulatory network: a toggle switch. This was realized by explicitly constructing the steady state probability of the gene switch in the protein concentration...

Brimonidine Blocks Glutamate Excitotoxicity-Induced Oxidative Stress and Preserves Mitochondrial Transcription Factor A in Ischemic Retinal Injury

Glutamate excitotoxicity-induced oxidative stress have been linked to mitochondrial dysfunction in retinal ischemia and optic neuropathies including glaucoma. Brimonindine (BMD), an alpha 2-adrenergic receptor agonist, contributes to the neuroprotection of retinal ganglion cells (RGCs) against glutamate excitotoxicity or oxidative stress. However, the molecular mechanisms of BMD...