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Search: authors:"Kiichi Ishiwata"

18 papers found.
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Reliable radiosynthesis of 4-[10B]borono-2-[18F]fluoro-l-phenylalanine with quality assurance for boron neutron capture therapy-oriented diagnosis

2 Department of Biofunctional Imaging, Fukushima Medical University , Fukushima , Japan 3 Kiichi Ishiwata 4 SHI Accelerator Service , Tokyo , Japan Objective The aim of this study was to establish a

Effects of glucose, insulin, and insulin resistance on cerebral 18F-FDG distribution in cognitively normal older subjects

Ishiwata, Kenji Ishii. Formal analysis: Kenji Ishibashi, Airin Onishi. Funding acquisition: Kenji Ishibashi. Investigation: Kenji Ishibashi, Airin Onishi, Yoshinori Fujiwara, Kiichi Ishiwata, Kenji Ishii ... Ishibashi. Writing ± review & editing: Kenji Ishibashi, Airin Onishi, Yoshinori Fujiwara, Kiichi Ishiwata, Kenji Ishii. 11 / 12 1. Kawasaki K , Ishii K , Saito Y , Oda K , Kimura Y , Ishiwata K. Influence

Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers

Background N,N-di-n-propyl-2-[2-(4-[11C]methoxyphenyl)-6,8-dichloroimidazol[1,2-a]pyridine-3-yl]acetamide ([11C]CB184) is a novel selective radioligand for the 18-kD translocator protein (TSPO), which is upregulated in activated microglia in the brain, and may be useful in positron emission tomography (PET). We examined the safety, radiation dosimetry, and initial brain imaging...

Determination of radionuclides and radiochemical impurities produced by in-house cyclotron irradiation and subsequent radiosynthesis of PET tracers

for Neuroscience , 7-115 Yatsuyamada, Koriyama 963-8052 , Japan 1 Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology , Tokyo , Japan 2 & Kiichi Ishiwata 3 Production Technology

Individual time course of pre- and postsynaptic PET imaging may improve differential diagnosis of Parkinson’s disease and multiple system atrophy: a case report

Background Many in vivo studies have shown a difference in pre- and/or postsynaptic imaging between Parkinson’s disease and multiple system atrophy; however, time course differences in pre- and postsynaptic imaging between Parkinson’s disease and multiple system atrophy have not been rigorously investigated. Case presentation We report serial positron emission tomography images...

Test-retest variability of adenosine A2A binding in the human brain with 11C-TMSX and PET

Background The goal of the present study was to evaluate the reproducibility of cerebral adenosine A2A receptor (A2AR) quantification using 11C-TMSX and PET in a test-retest study. Methods Five healthy volunteers were studied twice. The test-retest variability was assessed for distribution volume (VT) and binding potential relative to non-displaceable uptake (BPND) based on...

Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [11C]SA4503

Purpose Sigma-1 receptor ligands modulate the release of several neurotransmitters and intracellular calcium signaling. We examined the binding of a radiolabeled sigma-1 agonist in the aging rat brain with positron emission tomography (PET). Procedures Time-dependent uptake of [11C]SA4503 was measured in the brain of young (1.5 to 3 months) and aged (18 to 32 months) Wistar...

Evaluation of [11C]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis

Purpose Evaluation of translocator protein (TSPO) overexpression is considered an attractive research tool for monitoring neuroinflammation in several neurological and psychiatric disorders. [11C]PK11195 PET imaging has been widely used for this purpose. However, it has a low sensitivity and a poor signal-to-noise ratio. For these reasons, [11C]CB184 was evaluated as a...

A pilot study of 4′-[methyl-11C]-thiothymidine PET/CT for detection of regional lymph node metastasis in non-small cell lung cancer

, Jun Toyohara, and Kiichi Ishiwata), a Grant-in Aid for Scientific Research (B) No. 22390241 from the Japan Society for the Promotion of Science (to Jun Toyohara), and a Grant-in Aid for Young Scientists

Comparison of 11C-4′-thiothymidine, 11C-methionine, and 18F-FDG PET/CT for the detection of active lesions of multiple myeloma

Purpose The aims of this study were to evaluate the possibility of using 11C-methionine (11C-MET) and 11C-4′-thiothymidine (11C-4DST) whole-body PET/CT for the imaging of amino acid metabolism and DNA synthesis, respectively, when searching for bone marrow involvement in patients with multiple myeloma (MM) and to compare these findings with those for 18F-FDG PET/CT and aspiration...

Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [11C](R)-PK11195

Objective We report synthesis of two carbon-11 labeled imidazopyridines TSPO ligands, [11C]CB184 and [11C]CB190, for PET imaging of inflammatory process along with neurodegeneration, ischemia or brain tumor. Biodistribution of these compounds was compared with that of [11C]CB148 and [11C](R)-PK11195. Methods Both [11C]CB184 and [11C]CB190 having 11C-methoxyl group on an aromatic...

Binding of Pramipexole to Extrastriatal Dopamine D2/D3 Receptors in the Human Brain: A Positron Emission Tomography Study Using 11C-FLB 457

The purpose of this study was to determine the binding sites of pramipexole in extrastriatal dopaminergic regions because its antidepressive effects have been speculated to occur by activating the dopamine D2 receptor subfamily in extrastriatal areas. Dynamic positron emission tomography (PET) scanning using 11C-FLB 457 for quantification of D2/D3 receptor subtype was performed...

In Vivo Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists [11C]A-582941 and [11C]A-844606 in Mice and Conscious Monkeys

In Vivo Evaluation of a7 Nicotinic Acetylcholine Receptor 11 11 Agonists [ C]A-582941 and [ C]A-844606 in Mice and Conscious Monkeys Jun Toyohara 0 Kiichi Ishiwata 0 Muneyuki Sakata 0 Jin Wu 0 Shingo

Contributions of biological tumor parameters to the incorporation rate of l-[methyl-11C] methionine into astrocytomas and oligodendrogliomas

We compared the tumor uptake of 11C-methionine (MET) with positron emission tomography (PET) with the results of a pathological analysis to examine the proliferative potential and microvessel density measured with immunostaining for MIB-1 and factor VIII, respectively, from 33 patients with glioma. The MET uptake in oligodendrogliomas was significantly greater than that in grade...

Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients

Adenosine A2A receptors (A2ARs) are thought to interact negatively with the dopamine D2 receptor (D2R), so selective A2AR antagonists have attracted attention as novel treatments for Parkinson's disease (PD). However, no information about the receptor in living patients with PD is available. The purpose of this study was to investigate the relationship between A2ARs and the...

Steroid hormones affect binding of the sigma ligand 11C-SA4503 in tumour cells and tumour-bearing rats

Purpose Sigma receptors are implicated in memory and cognitive functions, drug addiction, depression and schizophrenia. In addition, sigma receptors are strongly overexpressed in many tumours. Although the natural ligands are still unknown, steroid hormones are potential candidates. Here, we examined changes in binding of the sigma-1 agonist 11C-SA4503 in C6 glioma cells and in...

Absorbed Dose Estimates in Positron Emission Tomography Studies Based on the Administration of 18f-Labeled Radiopharmaceuticals

Absorbed doses were estimated after intravenous administration of 18f-labeled radiopharmaceuticals in Positron Emission Tomography (PET) studies. These radiopharmaceuticals, [18f]-2-Fluoro-2-Deoxy-D-Glucose (FDG), 6-[189F]Fluoro-L-Dopa (FDOPA) and 18f-5-Fluorodeoxyuridine (FdUR), are used in clinical research at the Cyclotron and Radioisotope Center of Tohoku University...