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Search: authors:"Kirsi Vähäkangas"

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Maternal Smoking and the Risk of Cancer in Early Life – A Meta-Analysis

Background In spite of the well-known harmful effects on the fetus, many women continue smoking during pregnancy. Smoking as an important source of toxic chemicals may contribute to the developmental origin of diseases. Objectives The aim of this work was to pursue the possible association between maternal smoking and cancer in early life. Specifically, we wanted to identify the ...

Ethical aspects of molecular epidemiology of cancer

In molecular epidemiology of cancer where many studies are genetic in nature and they are done among healthy people, ethical issues require special consideration. Genetic information differs from other health care information in that it is predictive in nature, and it always involves at least family members, but in some genetically very homogeneous populations even a wider group. ...

Thapsigargin has similar effect on p53 protein response to benzo[a]pyrene–DNA adducts as TPA in mouse skin

The level of p53 tumor suppressor protein increases in response to DNA damage caused by benzo[a]pyrene (B[a]P). The most used tumor promoter in the two step mouse skin carcinogenesis model, 12-O-tetradecanoylphorbol-13-acetate (TPA) decreases this response in mouse skin. In this study the effect of another promoter, thapsigargin was tested on B[a]P-induced p53 response using ...

SHORT COMMUNICATION: TPA decreases the p53 response to benzo[a]pyrene-DNA adducts in vivo in mouse skin

TPA, a well-known tumor promoter, decreased the response of nuclear P53 immunoreactivity to benzo[a]pyrene-7, 8-diol-9, 10-epoxide (BPDE)-DNA adducts in C57BL/6 mouse skin in vivo. A dose-dependent increase in both the level of BPDE-DNA adducts and nuclear p53 immunoreactivity was found in mice treated topically with 50–750 μg benzo[a]pyrene. Such a positive correlation between the ...