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35 papers found.
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Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis

Medical Center, Omura, JapanYoshihiro Aiba, Masahiro Ito, Hitomi Nakamura, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Kiyoshi Migita, Hiroshi Yatsuhashi & Minoru NakamuraDepartment of Human Pathology ... , Atsumasa Komori, Kiyoshi Migita, Hiroshi Yatsuhashi & Minoru NakamuraCentral Electron Microscope Laboratory, Nagasaki University School of Medicine, Nagasaki, Nagasaki, JapanTakashi SuematsuDepartments of

Changes in N-glycans of IgG4 and its relationship with the existence of hypocomplementemia and individual organ involvement in patients with IgG4-related disease

Kobayashi, Kiyoshi Migita, Atsushi Komatsuda, Hiromasa Ohira, Hiroshi Watanabe. Software: Yoshiaki Miura, Taichi Aihara. Supervision: Kiyoshi Migita, Hiromasa Ohira, Hiroshi Watanabe. Validation: Hiroko ... Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Hiroshi Watanabe. Writing ± original draft: Naoki Konno, Hiroshi Watanabe. Writing ± review & editing: Hiroshi Watanabe. 18 / 21 19 / 21 20 / 21 Exp Immunol. 2004

TNF-α-induced miR-155 regulates IL-6 signaling in rheumatoid synovial fibroblasts

BackgroundMicroRNAs (miRNAs) are important regulators of a variety of inflammatory mediators. The present study was undertaken to elucidate the role of miRNAs in the rheumatoid cytokine network.MethodsWe analyzed miRNA expression in rheumatoid synovial fibroblasts (RASFs). miRNA array-based screening was used to identify miRNAs differentially expressed between tumor necrosis...

Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus

, Yoshiki Yamaguchi, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Hiroshi Watanabe. Supervision: Hiromasa Ohira, Yasuhiro Hashimoto, Hiroshi Watanabe. 15 / 18 Validation: Hiroko Kobayashi ... , Kiyoshi Migita, Hiromasa Ohira, Hiroshi Watanabe. Writing ± original draft: Tomoyuki Asano, Yasuhiro Hashimoto, Hiroshi Watanabe. Writing ± review & editing: Yasuhiro Hashimoto, Hiroshi Watanabe. 16 / 18 19

Factors Associated with Myelosuppression Related to Low-Dose Methotrexate Therapy for Inflammatory Rheumatic Diseases

Objective Severe myelosuppression is a serious concern in the management of rheumatic disease patients receiving methotrexate (MTX) therapy. This study was intended to explore factors associated with the development of MTX-related myelosuppression and its disease severity. Methods We retrospectively examined a total of 40 cases of MTX-related myelosuppression that had been filed...

HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype

The members of the NHO-AIH study group are: Kiyoshi Migita (Fukushima Medical University School of Medicine), Minoru Nakamura (Nagasaki University Graduate School of Biomedical Sciences), Hideo ... , Kazumichi Abe, Hiromasa Ohira, Naoyuki Tsuchiya, Kiyoshi Migita. Data curation: Hiroshi Furukawa. Formal analysis: Shomi Oka, Hiroshi Furukawa. Funding acquisition: Michio Yasunami, Kiyoshi Migita

Reduced induction of anti-PF4/heparin antibody in RA patients after total knee arthroplasty

Background Heparin-induced thrombocytopenia is caused by antibodies (Abs) specific to platelet factor 4 (PF4)/heparin complexes. In this study, we evaluated the rates of seroconversion of anti-PF4/heparin Ab between patients with rheumatoid arthritis (RA) and with osteoarthritis (OA) who underwent total knee arthroplasty. Methods The subjects of this randomized controlled trial...

Rapid Increase in Serum Low-Density Lipoprotein Cholesterol Concentration during Hepatitis C Interferon-Free Treatment

Background & Aim We performed lipid analyses at the early period of therapy in patients with chronic hepatitis C who underwent interferon (IFN)-free direct-acting antiviral (DAA) treatment, and we attempted to identify the factors that contributed to a rapid increase in the patients’ serum low-density lipoprotein cholesterol (LDL-C) concentration. Methods We retrospectively...

Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis

 Tatsuya Sawasaki,2 Toshio Heike,3 Kiyoshi Migita,4 Kazunaga Agematsu,5 Atsushi Kawakami,6 Shinnosuke Morikawa,1 Sho Mokuda,1 Mie Kurata,1 and Junya Masumoto1 1Department of Pathology, Ehime University ... approved the final version to be published. Tomoyuki Iwasaki and Junya Masumoto were responsible for study conception and design. Tomoyuki Iwasaki, Naoe Kaneko, Yuki Ito, Toshio Heike, Kiyoshi Migita

A Case of Relapsing Polychondritis Initiating with Unexplained Fever

Relapsing polychondritis (RP) is a rare autoimmune disease affecting the multiple organ system. Here, we describe a case of RP initially presenting with high fever. The patient was referred to our hospital for further examination of fever of unknown origin (FUO). On admission, the patient reported dry cough in addition to fever. On physical examination, her red, swollen ears were...

Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease

Nakamura Tomohiro Koga Toshimasa Shimizu Masataka Umeda Fumiaki Nonaka Michio Yasunami Yukitaka Ueki Katsumi Eguchi Naoyuki Tsuchiya Shigeto Tohma Koh-ichiro Yoshiura Hiromasa Ohira Atsushi Kawakami Kiyoshi ... Migita 0 0 Department of Rheumatology, Fukushima Medical University School of Medicine , 1 Hikarigaoka, Fukushima, Fukushima 960-1295 , Japan Background: HLA-DRB1 alleles are major determinants of

Fewer subsequent relapses and lower levels of IL-17 in Takayasu arteritis developed after the age of 40 years

Background The clinical characteristics of Takayasu arteritis (TAK) developing in individuals older than 40 years (TAK >40) are little-known. Method We retrospectively analyzed 43 patients with TAK treated at three hospitals in Japan from April 2000 to March 2016. From medical records we collected baseline variables at diagnosis including clinical symptoms, laboratory data, and...

The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial

Background Pneumococcal pneumonia is the most frequent form of pneumonia. We herein assessed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in the prevention of pneumonia overall in rheumatoid arthritis (RA) patients at risk for infections. We hypothesized that PPSV23 vaccination is superior in preventing pneumococcal pneumonia compared with...

Association between Anti-Ganglionic Nicotinic Acetylcholine Receptor (gAChR) Antibodies and HLA-DRB1 Alleles in the Japanese Population

Background/Aims Anti-ganglionic nicotinic acetylcholine receptor (gAChR) antibodies are observed in autoimmune diseases, as well as in patients with autoimmune autonomic ganglionopathy. However, the genetic background of anti-gAChR antibodies is unclear. Here, we investigated HLA alleles in autoimmune hepatitis (AIH) patients with or without anti-gAChR antibodies. Methodology...

Familial Mediterranean fever is no longer a rare disease in Japan

Background The aim of this study was to evaluate the clinical manifestations and prevalence of familial Mediterranean fever (FMF) in Japanese patients with unexplained fever and rheumatic manifestations. Methods We enrolled 601 patients with unexplained fever or suspected FMF throughout Japan between 2009 and 2015. Patients were divided into three groups according to Tel Hashomer...

Serum Amyloid A Induces NLRP-3-Mediated IL-1β Secretion in Neutrophils

Citation: Migita K, Izumi Y, Jiuchi Y, Kozuru H, Kawahara C, et al. ( Serum Amyloid A Induces NLRP-3-Mediated IL-1b Secretion in Neutrophils Kiyoshi Migita 0 Yasumori Izumi 0 Yuka Jiuchi 0 Hideko

Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever

Objectives The genotype-phenotype correlation of MEFV remains unclear for the familial Mediterranean fever (FMF) patients, especially without canonical MEFV mutations in exon 10. The risk of FMF appeared to be under the influence of other factors in this case. The contribution of HLA polymorphisms to the risk of FMF was examined as strong candidates of modifier genes. Methods...

Human Leukocyte Antigen and Systemic Sclerosis in Japanese: The Sign of the Four Independent Protective Alleles, DRB1*13:02, DRB1*14:06, DQB1*03:01, and DPB1*02:01

Objective Several studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic sclerosis (SSc) have been reported. Anti-centromere antibodies (ACA) and anti-topoisomerase I antibodies (ATA) are found in SSc patients. Here, we sought to identify HLA alleles associated with SSc in Japanese, and explored their associations with SSc...

Effect of abatacept on the immunogenicity of 23-valent pneumococcal polysaccharide vaccination (PPSV23) in rheumatoid arthritis patients

Introduction Patients with rheumatoid arthritis (RA) treated with abatacept (ABT) are at increased risk for vaccine-preventable infections. The aim of the present study is to evaluate the humoral response to 23-valent pneumococcal polysaccharide (PPSV23) vaccination in RA patients receiving ABT. Methods The immunogenicity study was nested within a randomized, double-blind placebo...

Protective Effect of the HLA-DRB1*13:02 Allele in Japanese Rheumatoid Arthritis Patients

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. Certain HLA-DRB1 “shared-epitope” alleles are reported to be positively associated with increased RA susceptibility, whereas some of the other alleles may be negatively associated. However, studies on the latter are rare. Here, we focus on the protective effects of DRB1 alleles in Japanese RA patients in an...