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Search: authors:"Koji Matsuoka"

4 papers found.
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Estimation of the abundance of the sei whale Balaenoptera borealis in the central and eastern North Pacific in summer using sighting data from 2010 to 2012

The abundance of the sei whale Balaenoptera borealis in the central and eastern North Pacific (north of 40°N, south of the Alaskan coast including both the US and Canadian Exclusive Economic Zones between 170°E and 135°W), from July to August, was estimated by the line transect method using sighting data obtained during the 2010–2012 International Whaling Commission-Pacific Ocean...

Inhibitory effects and specificity of synthetic sialyldendrimers toward recombinant human cytosolic sialidase 2 (NEU2)

Human sialidase 2 (NEU2) is a cytoplasmic sialidase that degrades sialylglycoconjugates, including glycoproteins and gangliosides, via hydrolysis of terminal sialic acids to produce asialo-type molecules. Here, we first report the inhibitory effects of a series of synthetic sialyldendrimers comprising three types [Dumbbell(1)6-S-Neu5Ac6, Fan(0)3-S-Neu5Ac3 and Ball(0)4-S-NeuAc4...

Identification of the Optimal Structure Required for a Shiga Toxin Neutralizer with Oriented Carbohydrates to Function in the Circulation

Shiga toxin (Stx) is a major virulence factor of Stx-producing Escherichia coli. Recently, we developed a therapeutic Stx neutralizer with 6 trisaccharides of globotriaosyl ceramide, a receptor for Stx, in its dendrimer structure (referred to as “SUPER TWIG [1]6”) to function in the circulation. Here, we determined the optimal structure of SUPER TWIG for it to function in the...

Oral Therapeutic Agents with Highly Clustered Globotriose for Treatment of Shiga Toxigenic Escherichia coli Infections

Shiga toxin (Stx) is a major virulence factor in infection with Stx-producing Escherichia coli (STEC). We developed a series of linear polymers of acrylamide, each with a different density of trisaccharide of globotriaosylceramide (Gb3), which is a receptor for Stx, and identified Gb3 polymers with highly clustered trisaccharides as Stx adsorbents functioning in the gut. The Gb3...