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Effects of time-delay in a model of intra- and inter-personal motor coordination

Motor coordination is an important feature of intra- and inter-personal interactions, and several scenarios — from finger tapping to human-computer interfaces — have been investigated experimentally. In the 1980s, Haken, Kelso and Bunz formulated a coupled nonlinear two-oscillator model, which has been shown to describe many observed aspects of coordination tasks. We present here a ...

Beyond in-phase and anti-phase coordination in a model of joint action

In 1985, Haken, Kelso and Bunz proposed a system of coupled nonlinear oscillators as a model of rhythmic movement patterns in human bimanual coordination. Since then, the Haken–Kelso–Bunz (HKB) model has become a modelling paradigm applied extensively in all areas of movement science, including interpersonal motor coordination. However, all previous studies have followed a line of ...

Bifurcation analysis of a two-compartment hippocampal pyramidal cell model

The Pinsky-Rinzel model is a non-smooth 2-compartmental CA3 pyramidal cell model that has been used widely within the field of neuroscience. Here we propose a modified (smooth) system that captures the qualitative behaviour of the original model, while allowing the use of available, numerical continuation methods to perform full-system bifurcation and fast-slow analysis. We study ...

Modulation of hippocampal gamma oscillations by acetylcholine: insights from mathematical and in vitro optogenetic models

Krasimira Tsaneva-Atanasova 0 1 2 0 References 1. Csicsvari J, Jamieson B, Wise KD, Buzsáki G: Mechanisms of gamma oscillations in the hippocampus of the behaving rat. Neuron 2003 , 37:311-322. 2. Pálhalmi

Design of a Virtual Player for Joint Improvisation with Humans in the Mirror Game

Joint improvisation is often observed among humans performing joint action tasks. Exploring the underlying cognitive and neural mechanisms behind the emergence of joint improvisation is an open research challenge. This paper investigates jointly improvised movements between two participants in the mirror game, a paradigmatic joint task example. First, experiments involving movement ...

RNA2DNAlign: nucleotide resolution allele asymmetries through quantitative assessment of RNA and DNA paired sequencing data

We introduce RNA2DNAlign, a computational framework for quantitative assessment of allele counts across paired RNA and DNA sequencing datasets. RNA2DNAlign is based on quantitation of the relative abundance of variant and reference read counts, followed by binomial tests for genotype and allelic status at SNV positions between compatible sequences. RNA2DNAlign detects positions ...

Bacterial Secretion and the Role of Diffusive and Subdiffusive First Passage Processes

By funneling protein effectors through needle complexes located on the cellular membrane, bacteria are able to infect host cells during type III secretion events. The spatio-temporal mechanisms through which these events occur are however not fully understood, due in part to the inherent challenges in tracking single molecules moving within an intracellular medium. As a result, ...

Modeling judgment of sequentially presented categories using weighting and sampling without replacement

In a series of experiments, Kusev et al. (Journal of Experimental Psychology: Human Perception and Performance 37:1874–1886, 2011) studied relative-frequency judgments of items drawn from two distinct categories. The experiments showed that the judged frequencies of categories of sequentially encountered stimuli are affected by the properties of the experienced sequences. ...

Dynamical systems analysis of spike-adding mechanisms in transient bursts

Jakub Nowacki 0 Hinke M Osinga 0 Krasimira Tsaneva-Atanasova 0 0 HM Osinga ( ) Department of Mathematics, The University of Auckland , Private Bag 92019, Auckland, 1142, New Zealand Transient

Modelling emergence of oscillations in communicating bacteria: a structured approach from one to many cells

Petros Mina Mario di Bernardo Nigel J. Savery Krasimira Tsaneva-Atanasova 0 School of Biochemistry, University of Bristol , Bristol, UK 1 Department of Engineering Mathematics 2 Bristol Center for

TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model

Sarcoplasmic/endoplasmic reticulum (SR) and nuclear membranes contain two related cation channels named TRIC-A and TRIC-B. In many tissues, both subtypes are co-expressed, making it impossible to distinguish the distinct single-channel properties of each subtype. We therefore incorporated skeletal muscle SR vesicles derived from Tric-a-knockout mice into bilayers in order to ...

A phenomenological model of seizure initiation suggests network structure may explain seizure frequency in idiopathic generalised epilepsy

We describe a phenomenological model of seizure initiation, consisting of a bistable switch between stable fixed point and stable limit-cycle attractors. We determine a quasi-analytic formula for the exit time problem for our model in the presence of noise. This formula--which we equate to seizure frequency--is then validated numerically, before we extend our study to explore the ...

Inhibition of Post-Synaptic Kv7/KCNQ/M Channels Facilitates Long-Term Potentiation in the Hippocampus

Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M1 mAChR on CA1 pyramidal cells inhibit both small conductance Ca2+-activated KCa2 potassium channels and voltage-activated Kv7 potassium channels. Inhibition of KCa2 channels facilitates long-term potentiation (LTP) by ...

Decoding GnRH neurohormone pulse frequency by convergent signalling modules

Krasimira Tsaneva-Atanasova () Petros Mina Christopher J. Caunt Stephen P. Armstrong Craig A. McArdle Articles on similar topics can be found in the following collections Receive free email alerts

Sensitivity analysis to explain the excitability in a pyramidal neuron with application to Alzheimer’s disease

Jakub Nowacki 0 Hinke M Osinga 0 Jon T Brown Andrew D Randall Krasimira Tsaneva-Atanasova 0 0 Bristol Centre for Applied Nonlinear Mathematics, Department of Engineering Mathematics, University of

FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6

Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca2+-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating. We have therefore investigated the effects of FKBP12.6 and another structurally similar molecule, FKBP12, which is far more abundant in heart, on the ...