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Search: authors:"Krystyna Pawlak"

8 papers found.
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Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease

Background During chronic kidney disease progression, kidney-specific risk factors for cardiovascular disease come into play. The present study investigated the impact of indoxyl sulfate, dietary tryptophan-derived uremic toxin, accumulated in the blood of patients with chronic kidney disease on hemostatic parameters, markers of inflammation, oxidative stress and monocyte to ...

The Association between Elevated Levels of Peripheral Serotonin and Its Metabolite – 5-Hydroxyindoleacetic Acid and Bone Strength and Metabolism in Growing Rats with Mild Experimental Chronic Kidney Disease

Kemona 1 Krystyna Pawlak 1 0 Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland, 2 Department of Monitored Pharmacotherapy, Medical University of Bialystok, Bialystok

Enoxaparin but not unfractionated heparin causes a dose-dependent increase in plasma TGF-β1 during haemodialysis: a cross-over study

Background. Transforming growth factor-β1 (TGF-β1) is a multi-functional cytokine that presents as a mediator of the heparin's pleiotropic action. In this cross-over study, we compared the effects of enoxaparin and unfractionated heparin (UFH) used as anticoagulants during haemodialysis (HD) on plasma TGF-β1 levels and some platelet activation markers: platelet-derived growth ...

Tissue factor and its inhibitor in human non-crescentic glomerulonephritis—immunostaining vs plasma and urinary levels

Background. Tissue factor (TF)—the most potent trigger of coagulation and emerging antiapoptotic, proliferative and angiogenic factor, along with its principal inhibitor (tissue factor pathway inhibitor, TFPI) are known to be involved in crescentic glomerulonephritis (GN). We studied the relationship between plasma and urinary levels as well as renal biopsy immunostaining of TF and ...

Renal function, proteinuria and ACE‐inhibitor therapy as determinants of plasma levels of endothelial markers

against endothelial injury in this high-risk population. Department of Nephrology and Internal Medicine Medical Academy Biakystok, Poland Email: Beata Naumnik Jacek Borawski Krystyna Pawlak Michak

Endothelial dysfunction marker von Willebrand factor antigen in haemodialysis patients: associations with pre‐dialysis blood pressure and the acute phase response

Background. Increased plasma soluble von Willebrand factor antigen (vWF : Ag) level, a marker of vascular endothelial cell dysfunction, is a strong predictor of atherosclerotic cardiovascular disease (CVD) in the general population. We studied cross‐sectional associations between vWF : Ag level, prevalence of CVD, and related factors including pre‐dialysis arterial blood pressure ...

Soluble thrombomodulin is associated with viral hepatitis, blood pressure, and medications in haemodialysis patients

Background. The level of soluble thrombomodulin (sTM), a traditional marker of endothelial injury, is also dependent on renal excretory function. We studied serum sTM in chronic haemodialysis (HD) patients to determine which factors are predictive of its levels in this population. Methods and results. sTM levels of 10.7 (5.72–30.7) ng/ml in 100 HD patients were higher than in 30 ...

A possible role of thrombin‐activatable fibrinolysis inhibitor in disturbances of fibrinolytic system in renal transplant recipients

Background. Cardiovascular disease (CVD) is a major cause of death in renal transplant recipients (RTR). Suppression of fibrinolysis plays a role in the progression of atherosclerosis. Accelerated progression of atherosclerosis and fibrinolytic system suppression has been observed in RTR. Despite many years of intensive research, the reason for impaired fibrinolysis in this patient ...