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From explicit to implicit orientation: mapping rank scale to modality in English and Chinese

' information Shu-Kun Chen is a lecturer in Guangdong University of Finance where he teaches English-Chinese translation and interpreting, college English, and cross-cultural communication. He has gained a PhD at

Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells

Anaplastic thyroid cancer (ATC) is highly aggressive and tends to develop drug resistance to standard chemotherapies. To overcome the drug resistance of ATC, we synthesized dopamine-melanin nanoparticles (MNPs) loaded with doxorubicin (Dox) molecules. The Dox-loaded MNPs (Dox-MNPs) developed exhibited increased cellular uptake and enhanced therapeutic efficacy in drug-resistant...

Impact of clinical pharmacist interventions on inappropriate prophylactic acid suppressant use in hepatobiliary surgical patients undergoing elective operations

the Acknowledgments study period. Author Contributions Funding acquisition: Hongli Luo. Investigation: Kun Chen. Methodology: Hongli Luo. Project administration: Shunlin Xiao. Software: Kun Chen

Similar Improvements in Patient-Reported Outcomes Among Rheumatoid Arthritis Patients Treated with Two Different Doses of Methotrexate in Combination with Adalimumab: Results From the MUSICA Trial

employee and may hold stock or stock options. Jenny Griffith is an AbbVie employee and may hold stock or stock options. Kun Chen is an AbbVie employee and may hold stock or stock options. Hartmut Kupper is

Detection of the spatial patterns of water storage variation over China in recent 70 years

Scholar Search for Jianjun Wu in:Nature Research journals • PubMed • Google Scholar Search for Kun Chen in:Nature Research journals • PubMed • Google Scholar Search for Yue Deng in:Nature Research

CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial

Affiliated Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaKangguang Lin, Guiyun Xu, Weicong Lu, Lijie Guan, Huiyi Ouyang, Kun Chen & Yamei DangLaboratory of Emotion and ... in:Nature Research journals • PubMed • Google Scholar Search for Huiyi Ouyang in:Nature Research journals • PubMed • Google Scholar Search for Kun Chen in:Nature Research journals • PubMed • Google Scholar

miR156 switches on vegetative phase change under the regulation of redox signals in apple seedlings

Atrbohd and Atrbohd mutants. Author Contributions Xinzhong Zhang conceived and designed the experiments, Xiaolin Jia, Xiaozhao Xu and Fei Shen conducted the experiments, Xiaolin Jia, Ya Kun Chen, Qing Bo

Fully bio-based, highly toughened and heat-resistant poly(L-lactide) ternary blends via dynamic vulcanization with poly(D-lactide) and unsaturated bioelastomer

Inherent brittleness and low heat resistance are the two major obstacles that hinder the wide applications of poly(L-lactide) (PLLA). In this study, we report a fully biobased, highly toughened and heat-resistant PLLA ternary blend, which was prepared by dynamic vulcanization of PLLA with poly(D-lactide) (PDLA) and an unsaturated bioelastomer (UBE). The results indicated that...

Calcium supplementation improves clinical outcome in intensive care unit patients: a propensity score matched analysis of a large clinical database MIMIC-II

Observational studies have linked hypocalcemia with adverse clinical outcome in critically ill patients. However, calcium supplementation has never been formally investigated for its beneficial effect in critically ill patients. To investigate whether calcium supplementation can improve 28-day survival in adult critically ill patients. Secondary analysis of a large clinical...

Soil Texture and Cultivar Effects on Rice (Oryza sativa, L.) Grain Yield, Yield Components and Water Productivity in Three Water Regimes

Kun Chen 1 0 Texas A&M AgriLife Research Center at Beaumont , 1509 Aggie Dr., Beaumont, TX, 77713 , United States of America, 2 International Crops Research Institute for the Semi-Arid Tropics

APACHE III Outcome Prediction in Patients Admitted to the Intensive Care Unit with Sepsis Associated Acute Lung Injury

Background and objective Acute Physiology and Chronic Health Evaluation (APACHE) III score has been widely used for prediction of clinical outcomes in mixed critically ill patients. However, it has not been validated in patients with sepsis-associated acute lung injury (ALI). The aim of the study was to explore the calibration and predictive value of APACHE III in patients with...

Reversible proton-switchable fluorescence controlled by conjugation effect in an organically-functionalized polyoxometalate

information Author notesChunlin Lv & Kun Chen These authors contributed equally to this work. AffiliationsDepartment of Chemistry, Tsinghua University, Beijing 100084, ChinaChunlin Lv, Kun Chen, Jin Zhang, Rao ... University, Beijing 100191, ChinaYongge Wei AuthorsSearch for Chunlin Lv in:Nature Research journals • PubMed • Google ScholarSearch for Kun Chen in:Nature Research journals • PubMed • Google ScholarSearch for

Accurate detection for a wide range of mutation and editing sites of microRNAs from small RNA high-throughput sequencing profiles

Various types of mutation and editing (M/E) events in microRNAs (miRNAs) can change the stabilities of pre-miRNAs and/or complementarities between miRNAs and their targets. Small RNA (sRNA) high-throughput sequencing (HTS) profiles can contain many mutated and edited miRNAs. Systematic detection of miRNA mutation and editing sites from the huge volume of sRNA HTS profiles is...

Neuropsychiatric Symptoms in Parkinson’s Disease Dementia Are More Similar to Alzheimer’s Disease than Dementia with Lewy Bodies: A Case-Control Study

Background and purpose Previous studies on the clinical and pathological manifestations of Parkinson’s disease dementia (PDD) have reported findings more similar to dementia with Lewy bodies (DLB) than to Alzheimer’s disease (AD). The aim of this study was to investigate the neuropsychiatric symptoms of PDD compared to DLB and AD. Methods We conducted a retrospective case-control...

Management of adrenal incidentaloma: the role of adrenalectomy may be underestimated

Background To demonstrate clinical characteristics of adrenal incidentaloma in South China and explore its comprehensive management. Methods The clinical data of patients with adrenal neoplasm from Jan 1998 to Dec 2012 were retrospectively analysed. Patients with suspicion of adrenal abnormalities or those in whom adrenal abnormalities were detected in the staging procedures of...

Consolidation chemotherapy improves progression-free survival in stage III small-cell lung cancer following concurrent chemoradiotherapy: a retrospective study

analysis - open access to scientific and medical research O r i g i n a l r e s e a r c h shu-Xiang Ma 1 n ing-n ing Zhou1 hai liao 1 De-lan li 1 li-Kun chen 1 1Department of Medical Oncology, 2Department ... *These authors contributed equally to this work correspondence: li-Kun chen Department of Medical Oncology, state Key laboratory of Oncology in south china, collaborative innovation center for cancer

Discovery of Potential Orthosteric and Allosteric Antagonists of P2Y1R from Chinese Herbs by Molecular Simulation Methods

P2Y1 receptor (P2Y1R), which belongs to G protein-coupled receptors (GPCRs), is an important target in ADP-induced platelet aggregation. The crystal structure of P2Y1R has been solved recently, which revealed orthosteric and allosteric ligand-binding sites with the details of ligand-protein binding modes. And it suggests that P2Y1R antagonists, which recognize two distinct sites...

Exposure to Organochlorine Pollutants and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Objective Though exposure to organochlorine pollutants (OCPs) is considered a risk factor for type 2 diabetes (T2DM), epidemiological evidence for the association remains controversial. A systematic review and meta-analysis was applied to quantitatively evaluate the association between exposure to OCPs and incidence of T2DM and pool the inconsistent evidence. Design and Methods...

microRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18

Background MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptional regulate gene expression in a variety of cancers. Increasing evidences indicate that miR-30 expression is down-regulated in numerous human cancers including non-small cell lung cancer (NSCLC) which hypothesizes that miR-30 may play an important role in tumorigenesis. The aim of this study was to...

Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

Background A unique feature of the pathological change after spinal cord injury (SCI) is the progressive enlargement of lesion area, which usually results in cavity formation and is accompanied by reactive astrogliosis and chronic inflammation. Reactive astrocytes line the spinal cavity, walling off the lesion core from the normal spinal tissue, and are thought to play multiple...