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LAB-PEDIATRICS LABORATORY RESEARCH

Chromosomal rearrangements resulting in novel fusion genes are among the most prevalent form of genetic alterations known in cancer, and numerous examples exist in both adult and childhood malignancies. To date, however, none have been reported in pediatric high-grade glioma (pHGG), so we have undertaken to search for novel structural rearrangements using three distinct...

FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization

Single nucleotide polymorphism (SNP) prioritization based on the phenotypic risk is essential for association studies. Assessment of the risk requires access to a variety of heterogeneous biological databases and analytical tools. FASTSNP (function analysis and selection tool for single nucleotide polymorphisms) is a web server that allows users to efficiently identify and...

Functional analysis of novel SNPs and mutations in human and mouse genomes

Background With the flood of information generated by the new generation of sequencing technologies, more efficient bioinformatics tools are needed for in-depth impact analysis of novel genomic variations. FANS (Functional Analysis of Novel SNPs) was developed to streamline comprehensive but tedious functional analysis steps into a few clicks and to offer a carefully designed...

Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action

Background Breast cancer is the second leading cause of cancer related deaths among females worldwide. Berbamine (BER), a kind of bis-benzylisoquinoline alkaloid, has been used to treat clinical patients with inflammation and cancer for many years in China. The purpose of this study is to investigate the activity of BER against highly-metastatic human breast cancer and its...

GenoWatch: a disease gene mining browser for association study

A human gene association study often involves several genomic markers such as single nucleotide polymorphisms (SNPs) or short tandem repeat polymorphisms, and many statistically significant markers may be identified during the study. GenoWatch can efficiently extract up-to-date information about multiple markers and their associated genes in batch mode from many relevant...

The Antibody Targeting the E314 Peptide of Human Kv1.3 Pore Region Serves as a Novel, Potent and Specific Channel Blocker

Selective blockade of Kv1.3 channels in effector memory T (TEM) cells was validated to ameliorate autoimmune or autoimmune-associated diseases. We generated the antibody directed against one peptide of human Kv1.3 (hKv1.3) extracellular loop as a novel and possible Kv1.3 blocker. One peptide of hKv1.3 extracellular loop E3 containing 14 amino acids (E314) was chosen as an...

Case-Fatality Ratio and Effectiveness of Ribavirin Therapy Among Hospitalized Patients in China Who Had Severe Fever With Thrombocytopenia Syndrome

Background. The wide distribution and high case-fatality ratio of severe fever with thrombocytopenia syndrome (SFTS) have made it a significant public health problem. This study was designed to identify the predictors of fatal outcomes and to evaluate the effectiveness of antiviral therapy in treating SFTS virus (SFTSV)–infected patients. Methods. A cross-sectional study was...

Silver-coated TiO2 nanostructured anode materials for lithium ion batteries

Anatase TiO2 nanoribbons/nanotubes (TiO2-NRTs) have been synthesised successfully via a reflux method followed by drying in a vacuum oven, and then, silver-coated TiO2 NRTs (Ag/TiO2-NRTs) were prepared by coating silver particles onto the TiO2-NRTs surface by the traditional silver mirror reaction. The physical properties of the synthesised products were examined in detail using...

PROPERTY RIGHTS, DEPENDENCE ON TRANSACTION PARTNERS, AND FIRM VALUATION: WHO APPROPRIATES VALUE? (INTERACTIVE PAPER)

A key issue gaining attention in the field of entrepreneurship is answering the question of who will appropriate the rents associated with entrepreneurial activity. While entrepreneurs may expend substantial resources to pursue an opportunity, others may be able to appropriate value if the entrepreneurs have not established protections. For example, a key supplier who provides a...

INFORMATION DISCLOSURE AND IPO VALUATION: WHAT KINDS OF INFORMATION MATTER AND IS MORE INFORMATION ALWAYS BETTER?

University, USA Fariss Mousa, Washington State University, USA Kun Liu, Washington State University , USA Daeil Nam Recommended Citation Nam, Daeil; Arthurs, Jonathan D.; Nielsen, Marsha; Mousa, Fariss; and

Regulation of HSP27 on NF-κB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis

Background During the process of metastasis, cells are subjected to various apoptotic stimuli. Aberrant expression of apoptotic regulators often contribute to cell metastasis. Heat shock protein 27(HSP27) is confirmed as an apoptosis regulator, but its antiapoptotic mechanism in metastatic hepatocellular carcinoma (HCC) cells remains unclear. Methods Levels of HSP27 protein and...

Epidemiologic Features and Environmental Risk Factors of Severe Fever with Thrombocytopenia Syndrome, Xinyang, China

Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in rural areas of Central China in 2009, caused by a novel bunyavirus, SFTS virus (SFTSV). The disease usually presents as fever, thrombocytopenia, and leukocytopenia, with case-fatality rates ranging from 2.5% to 30%. Haemaphysalis longicornis was suspected to be the most...

Mimotopes selected with neutralizing antibodies against multiple subtypes of influenza A

Background The mimotopes of viruses are considered as the good targets for vaccine design. We prepared mimotopes against multiple subtypes of influenza A and evaluate their immune responses in flu virus challenged Balb/c mice. Methods The mimotopes of influenza A including pandemic H1N1, H3N2, H2N2 and H1N1 swine-origin influenza virus were screened by peptide phage display...

A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

Background Differential diagnosis of high-grade dysplastic nodules (HGDN) and well-differentiated hepatocellular carcinoma (WDHCC) represents a challenge to experienced hepatic clinicians, radiologists and hepatopathologists. Methods The expression profiles of aminoacylase-1 (ACY1), sequestosome-1 (SQSTM1) and glypican-3 (GPC3) in low-grade dysplastic nodules (LGDN), HGDN and...

Interactions between galectin-3 and integrinβ3 in regulating endometrial cell proliferation and adhesion

BACKGROUND Galectin-3 (gal-3) is a β-galactoside-binding protein which can be detected in endometrium. The study was designed to investigate synergism of gal-3 and integrinβ3 in endometrial cell proliferation and adhesion in an in vitro model of endometrial receptivity. METHODS The RL95-2 cell line was employed as an in vitro model for receptive endometrium. Cells transfected...

Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation

Recently, we found strong overexpression of the mucin-type glycoprotein podoplanin (PDPN) in human astrocytic brain tumors, specifically in primary glioblastoma multiforme (GB). In the current study, we show an inverse correlation between PDPN expression and PTEN levels in primary human GB and glioma cell lines, and we report elevated PDPN protein levels in the subventricular...

Response of BALB/c mice to a monovalent influenza A (H1N1) 2009 split vaccine

The novel influenza A (H1N1) 2009 virus has emerged to cause the first pandemic of the twenty-first century. Disease outbreaks caused by the influenza A (H1N1) virus have prompted concerns about the potential for a pandemic and have driven the development of vaccines against this subtype of influenza A. In this study, we developed a monovalent influenza A (H1N1) split vaccine and...

FOUNDERS, GOVERNANCE, AND FIRM VALUATION: DOES THE MARKET PERCEIVE PSYCHOLOGICAL OWNERSHIP?

We examine the impact of the governance in entrepreneurial firms at the time of the IPO focusing on market valuation based on whether the founder is still with the company. Using agency theory to explain the governance devices (and their purpose), we probe their impact on firm valuation. We develop hypotheses using concepts from psychological ownership to explain why the devices...

FOUNDERS, GOVERNANCE, AND FIRM VALUATION: DOES THE MARKET PERCEIVE PSYCHOLOGICAL OWNERSHIP?

We examine the impact of the governance in entrepreneurial firms at the time of the IPO focusing on market valuation based on whether the founder is still with the company. Using agency theory to explain the governance devices (and their purpose), we probe their impact on firm valuation. We develop hypotheses using concepts from psychological ownership to explain why the devices...