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Search: authors:"Kurtis E. Bachman"

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A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells

comments. Author Contributions Conceptualization: Vinod Krishna, Kurtis E. Bachman. Funding acquisition: Kurtis E. Bachman. Investigation: Vinod Krishna. Methodology: Vinod Krishna. Project ... administration: Vinod Krishna, Kurtis E. Bachman. Resources: Vinod Krishna, Kurtis E. Bachman. Software: Vinod Krishna. Writing ± original draft: Vinod Krishna, Kurtis E. Bachman. Writing ± review & editing

DNA methylation, chromatin inheritance, and cancer

information AffiliationsThe Johns Hopkins Oncology Center, Tumor Biology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21231, USAMichael R Rountree, Kurtis E Bachman ... , James G Herman & Stephen B Baylin AuthorsSearch for Michael R Rountree in:Nature Research journals • PubMed • Google ScholarSearch for Kurtis E Bachman in:Nature Research journals • PubMed • Google

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

Gene function in cancer can be disrupted either through genetic alterations, which directly mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene expression. The latter events are mediated by formation of transcriptionally repressive chromatin states around gene transcription start sites and an associated gain of methylation in normally...